Protein Overview: CKS1

General Information:
Name(s) found:	CKS1 / YBR135W [SGD]
Description(s) found: Found 41 descriptions. SHOW ALL	Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters [SGD]
Organism:	Saccharomyces cerevisiae
Length:	150 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	transcription [IMP]
Molecular Function:	ubiquitin binding [IDA] protein kinase activator activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYHHYHAFQG RKLTDQERAR VLEFQDSIHY SPRYSDDNYE YRHVMLPKAM LKVIPSDYFN  60
   61 SEVGTLRILT EDEWRGLGIT QSLGWEHYEC HAPEPHILLF KRPLNYEAEL RAATAAAQQQ 120
  121 QQQQQQQQQQ QQQHQTQSIS NDMQVPPQIS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CDC28 CKS1 CLB3 CLN1 CLN2 SIC1
View Details	Krogan NJ, et al. (2006)		ATE1 CDC28 CKS1 CLB2 CLB3 CLB4 CLB5 SIC1 SKG3
View Details	Gavin AC, et al. (2006)		CDC28 CKS1 CLN2 CYS4 SIC1
View Details	Gavin AC, et al. (2002)		CDC28 CKS1 CLB3 CLN1 CLN2 DAL7 PCA1 SIC1 SRL3 YPL014W
View Details	Ho Y, et al. (2002)		BUR2 CDC28 CKS1 CLB2 CLB3 CLB5 CLN1 DIA2 HYP2 PGM2 YDR170W-A YER138C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	ZDS1	Sample zds1 from august 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	CKS1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CKS1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..150]	MSA	15.018981	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
cyclin-dependent protein kinase regulator activity	3.97841828100668	bayes_pls_golite062009
binding	2.18113207610794	bayes_pls_golite062009
protein binding	1.97943309243131	bayes_pls_golite062009
protein kinase regulator activity	1.37860707665544	bayes_pls_golite062009
kinase regulator activity	1.32978090173102	bayes_pls_golite062009
protein kinase binding	0.944579171364175	bayes_pls_golite062009
kinase binding	0.867010292327918	bayes_pls_golite062009
enzyme binding	0.54410658997703	bayes_pls_golite062009
enzyme regulator activity	0.334428481657021	bayes_pls_golite062009
small conjugating protein binding	0.32298430897304	bayes_pls_golite062009
ubiquitin binding	0.2354005843111	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2