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Protein Overview: AST1

General Information:
Name(s) found: AST1 / YBL069W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 429 amino acids

    Gene Ontology:
    Cellular Component: extrinsic to membrane [TASLink to PubMed article]
    Biological Process: protein targeting to membrane [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKDILKNQD PKLQAMIVEH SAPAPKEIPM DAPVLKRVAR PLRHVKFIPI KSLIFHTKTG  60
   61 PMDFSYEKKI KTPIPKNKIV VRVSNVGLNP VDMKIRNGYT SSIYGEIGLG REYSGVITEV 120
  121 GENLNYAWHV GDEVYGIYYH PHLAVGCLQS SILVDPKVDP ILLRPESVSA EEAAGSLFCL 180
  181 ATGYNILNKL SKNKYLKQDS NVLINGGTSS VGMFVIQLLK RHYKLQKKLV IVTSANGPQV 240
  241 LQEKFPDLAD EMIFIDYLTC RGKSSKPLRK MLEEKKISQY DPVEDKETIL NYNEGKFDVV 300
  301 LDFVGGYDIL SHSSSLIHGG GAYVTTVGDY VANYKEDIFD SWDNPSANAR KMFGSIIWSY 360
  361 NYTHYYFDPN AKTASANNDW IEQCGDFLKN GTVKCVVDKV YDWKDHKEAF SYMATQRAQG 420
  421 KLIMNVEKF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 AST1 2 Unpublished Fields Lab Data
    View Screen LSM8 AST1 1 Unpublished Fields Lab Data
    View Screen NUP2 AST1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data AST1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..209]
    [374..429]    		 PSI-BLAST 121.0 Alcohol dehydrogenase
    2 View Details [210..373] PSI-BLAST 121.0 Alcohol dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  4.14217990101505 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.13774251017711 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.96417104841008 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  1.68027744358887 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  1.22416351603098 bayes_pls_golite062009
  • chaperone binding
    		•  1.19079350615542 bayes_pls_golite062009
  • DNA binding
    		•  1.02274180655721 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.955628854752953 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.905392379451071 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.901776352952123 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.839863523675468 bayes_pls_golite062009
  • transporter activity
    		•  0.793769336118517 bayes_pls_golite062009
  • structural molecule activity
    		•  0.75267483298133 bayes_pls_golite062009
  • ligase activity
    		•  0.742884668104576 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.635891484075352 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.555188550031886 bayes_pls_golite062009
  • binding
    		•  0.553666136934364 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.51503848775098 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.410307505174239 bayes_pls_golite062009
  • transcription factor activity
    		•  0.368443846770004 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.29802814097478 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.261132005311306 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.239024094835991 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.212092278332619 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.113340150368917 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0696058100530442 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0591634687578807 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0560606007580392 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle