Protein Overview: ACS1

General Information:
Name(s) found:	ACS1 / YAL054C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319264\|ref\|NP_009347.1\| Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions; Acs1p [Saccharomyces cer [NCBI NR] gi\|595532\|gb\|AAC04979.1\| Acs1p: acetyl CoA synthetase [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S30019 acetate-CoA ligase (EC 6.2.1.1) ACS1, aerobic form [validated] - yeast (Saccharomyces cerevisiae) [NCBI NR] Acetyl-coenzyme A synthetase 1 OS=Saccharomyces cerevisiae GN=ACS1 PE=1 SV=2 [Swiss-Prot] ACS1 Acetyl-CoA synthetase [mips] Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions [SGD] ACS1, Chr I from 42881-45022, reverse complement [yeast_orfs2] Chr I from 42881-45022, reverse complement [yeastorf3.fasta] Chr I from 45022-42881, reverse complement [yeastorf5.fasta] ACS1 SGDID:S0000050, Chr I from 45023-42882, reverse complement, Verified ORF [yeastflysequest.fasta] Acs1p [Saccharomyces cerevisiae]gi\|1070527\|pir\|\|S30019 acetate-CoA ligase (EC 6.2.1.1) ACS1, aerobic form [validated] - yeast (Saccharomyces cerevisiae)gi\|595532\|gb\|AAC04979.1\| Acs1p: acetyl CoA synthetase [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] ACS1 SGDID:S000000050, Chr I from 45023-42882, reverse complement, Verified ORF, "Acetyl-coA synthetase isoform, expressed during growth on nonfermentable carbon sources and under aerobic conditions" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ACS1 SGDID:S000000050, Chr I from 45023-42882, reverse complement, Verified ORF, "Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources [yeast-contam.fasta] Acs1p: acetyl CoA synthetase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions; Acs1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ACS1 SGDID:S000000050, Chr I from 45023-42882, reverse complement, Verified ORF, "Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Acetyl-coenzyme A synthetase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACS1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ACS1 SGDID:S000000050, Chr I from 45022-42881, Genome Release 64-1-1, reverse complement, Verified ORF, "Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions" [yeast-030211-contam.fasta] ACS1 SGDID:S000000050, Chr I from 45022-42881, Genome Release 64-2-1, reverse complement, Verified ORF, "Acetyl-coA synthetase isoform; along with Acs2p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions" [20141208_orf_trans.fasta] YAL054C SGDID:S000000050, Chr I from 45022-42881, Genome Release 64-1-1, reverse complement, Verified ORF, "Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	713 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ] cytosol [IDA]
Biological Process:	acetyl-CoA biosynthetic process [IDA] histone acetylation [IGI] acetate fermentation [IMP]
Molecular Function:	acetate-CoA ligase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPSAVQSSK LEEQSSEIDK LKAKMSQSAA TAQQKKEHEY EHLTSVKIVP QRPISDRLQP  60
   61 AIATHYSPHL DGLQDYQRLH KESIEDPAKF FGSKATQFLN WSKPFDKVFI PDPKTGRPSF 120
  121 QNNAWFLNGQ LNACYNCVDR HALKTPNKKA IIFEGDEPGQ GYSITYKELL EEVCQVAQVL 180
  181 TYSMGVRKGD TVAVYMPMVP EAIITLLAIS RIGAIHSVVF AGFSSNSLRD RINDGDSKVV 240
  241 ITTDESNRGG KVIETKRIVD DALRETPGVR HVLVYRKTNN PSVAFHAPRD LDWATEKKKY 300
  301 KTYYPCTPVD SEDPLFLLYT SGSTGAPKGV QHSTAGYLLG ALLTMRYTFD THQEDVFFTA 360
  361 GDIGWITGHT YVVYGPLLYG CATLVFEGTP AYPNYSRYWD IIDEHKVTQF YVAPTALRLL 420
  421 KRAGDSYIEN HSLKSLRCLG SVGEPIAAEV WEWYSEKIGK NEIPIVDTYW QTESGSHLVT 480
  481 PLAGGVTPMK PGSASFPFFG IDAVVLDPNT GEELNTSHAE GVLAVKAAWP SFARTIWKNH 540
  541 DRYLDTYLNP YPGYYFTGDG AAKDKDGYIW ILGRVDDVVN VSGHRLSTAE IEAAIIEDPI 600
  601 VAECAVVGFN DDLTGQAVAA FVVLKNKSSW STATDDELQD IKKHLVFTVR KDIGPFAAPK 660
  661 LIILVDDLPK TRSGKIMRRI LRKILAGESD QLGDVSTLSN PGIVRHLIDS VKL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SNX41	ACS1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ACS1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..102]	MSA	3.509997	View MSA. No confident structure predictions are available.
2	View Details	[103..117] [387..574]	PSI-BLAST	277.218487	Phenylalanine activating domain of gramicidin synthetase 1
3	View Details	[118..168] [322..386] [575..713]	PSI-BLAST	277.218487	Phenylalanine activating domain of gramicidin synthetase 1
4	View Details	[169..321]	PSI-BLAST	277.218487	Phenylalanine activating domain of gramicidin synthetase 1

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
ligase activity, forming carbon-sulfur bonds	5.10123876514454	bayes_pls_golite062009
fatty acid ligase activity	4.83067429373059	bayes_pls_golite062009
long-chain fatty acid-CoA ligase activity	4.72692389032116	bayes_pls_golite062009
acetate-CoA ligase activity	4.48129067128523	bayes_pls_golite062009
acid-thiol ligase activity	4.28278725989432	bayes_pls_golite062009
CoA-ligase activity	4.12850865352867	bayes_pls_golite062009
ligase activity	2.49556073715112	bayes_pls_golite062009
catalytic activity	1.83545185797733	bayes_pls_golite062009
binding	1.5312519256537	bayes_pls_golite062009
transporter activity	1.29780964436121	bayes_pls_golite062009
transmembrane transporter activity	1.07143339827205	bayes_pls_golite062009
acetoacetate-CoA ligase activity	1.03788694975627	bayes_pls_golite062009
substrate-specific transporter activity	1.03753946113449	bayes_pls_golite062009
protein binding	0.985225190358794	bayes_pls_golite062009
transcription regulator activity	0.950362540931728	bayes_pls_golite062009
AMP binding	0.778227294974491	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.54797726647835	bayes_pls_golite062009
adenyl ribonucleotide binding	0.519946577969422	bayes_pls_golite062009
adenyl nucleotide binding	0.500908589473269	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.464663038956639	bayes_pls_golite062009
luciferin monooxygenase activity	0.460892968031761	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.398310577427897	bayes_pls_golite062009
active transmembrane transporter activity	0.251681382273558	bayes_pls_golite062009
primary active transmembrane transporter activity	0.225448500718996	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.216579620878492	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.177812048124158	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.174283007890308	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.173963339749644	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0401881910649647	bayes_pls_golite062009
pyrophosphatase activity	0.0047964784091391	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.77

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2