YRC Public Data Repository - Protein Structure Prediction

Protein:	ACS1
Organism:	Saccharomyces cerevisiae
Length:	713 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACS1.

Description	E-value	Query Range	Subject Range
ACS1_YEAST - Acetyl-coenzyme A synthetase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACS1 PE=1... ACS1 - Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histo...	0.0	[1..713]	[1..713]
ACSA2_PSEAE, ACS... - Acetyl-coenzyme A synthetase 2 OS=Pseudomonas aeruginosa GN=acsA2 PE=3 SV=1, (Q9HV66) Acetyl-coenzym... ACSA2_PSEAE - Acetyl-coenzyme A synthetase 2 OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / ...	0.0	[54..709]	[2..640]
gi\|17986522, gi\|... - gi\|17986522\|ref\|NP_539156.1\| acetyl-coenzyme A synthetase [Brucella melitensis 16M], gi\|17982126\|gb\|... gi\|25293392 - gi\|25293392\|pir\|\|AI3281 acetate-CoA ligase (EC 6.2.1.1) [imported] - Brucella melitensis (strain 16M...	0.0	[46..709]	[12..664]
ACSA_SALTI - Acetyl-coenzyme A synthetase OS=Salmonella typhi GN=acs PE=3 SV=1 gi\|213427241 - gi\|213427241\|ref\|ZP_03359991.1\| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar T... gi\|213163052 - gi\|213163052\|ref\|ZP_03348762.1\| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar T... gi\|16762956 - gi\|16762956\|ref\|NP_458573.1\| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar Typh... ACSA_SALTI - Acetyl-coenzyme A synthetase OS=Salmonella typhi GN=acs PE=3 SV=1 gi\|29144443, gi\|... - gi\|29144443\|ref\|NP_807785.1\| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar Typh... gi\|214002545 - gi\|214002545\|ref\|ZP_03413280.1\| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar T... gi\|213852760 - gi\|213852760\|ref\|ZP_03382292.1\| acetyl-CoA synthetase [Salmonella enterica subsp. enterica serovar T...	0.0	[62..710]	[10..644]
ACSA_SALTY - Acetyl-coenzyme A synthetase OS=Salmonella typhimurium GN=acs PE=1 SV=1 ACSA_SALTY - Acetyl-coenzyme A synthetase OS=Salmonella typhimurium GN=acs PE=1 SV=1 lcl\|NC_016856.1_... - [gene=acs] [protein=acetyl-CoA synthetase] [protein_id=YP_005240576.1] [location=complement(4527256.... gi\|197244220, gi... - gi\|197265965\|ref\|ZP_03166039.1\| acetate--CoA ligase [Salmonella enterica subsp. enterica serovar Sai... ACSA_SALTY - Acetyl-coenzyme A synthetase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=acs ... gi\|205330151, gi... - gi\|205330151\|gb\|EDZ16915.1\| acetate--CoA ligase [Salmonella enterica subsp. enterica serovar 4,[5],1...	0.0	[62..710]	[10..644]
gi\|254164004, gi... - gi\|254164004\|ref\|YP_003047112.1\| acetyl-coenzyme A synthetase [Escherichia coli B str. REL606], gi\|2... gi\|83587193, gi\|... - gi\|83587193\|ref\|ZP_00925822.1\| COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Escher... gi\|157159006, gi... - gi\|75188792\|ref\|ZP_00702059.1\| COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Escher... gi\|194426861, gi... - gi\|75211996\|ref\|ZP_00712051.1\| COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Escher... gi\|75238604, gi\|... - gi\|75238604\|ref\|ZP_00722593.1\| COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Escher... gi\|75258987, gi\|... - gi\|75258987\|ref\|ZP_00730355.1\| COG0365: Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Escher... EG11448 - acetyl-CoA synthetase / Acetyl CoA synthase, acetate-scavenging enzyme, improves carbon starvation s... gi\|85676821, gi\|... - gi\|89110790\|ref\|AP_004570.1\| bifunctional acetyl-CoA synthetase and propionyl-CoA synthetase [Escher... EG11448 - acetyl-CoA synthetase / Acetyl CoA synthase, acetate-scavenging enzyme, improves carbon starvation s... ACSA_ECOLI - Acetyl-coenzyme A synthetase (EC 6.2.1.1) (Acetate--CoA ligase) (Acyl-activating enzyme) - Escherich... gi\|218697778, gi... - gi\|218697778\|ref\|YP_002405445.1\| acetyl-CoA synthetase [Escherichia coli 55989], gi\|218354510\|emb\|CA... gi\|218556627, gi... - gi\|218556627\|ref\|YP_002389541.1\| acetyl-CoA synthetase [Escherichia coli IAI1], gi\|218363396\|emb\|CAR... gi\|169756860, gi... - gi\|170021932\|ref\|YP_001726886.1\| acetyl-CoA synthetase [Escherichia coli ATCC 8739], gi\|169756860\|gb... gi\|238903178, gi... - gi\|238903178\|ref\|YP_002928974.1\| acetyl-CoA synthetase [Escherichia coli BW2952], gi\|238859913\|gb\|AC... gi\|251787323, gi... - gi\|251787323\|ref\|YP_003001627.1\| hypothetical protein B21_03901 [Escherichia coli BL21], gi\|24237959... gi\|124527708, gi... - gi\|124527708\|ref\|ZP_01699143.1\| acetate--CoA ligase [Escherichia coli B], gi\|124501151\|gb\|EAY48617.1... gi\|209921555, gi... - gi\|209921555\|ref\|YP_002295639.1\| acetyl-CoA synthetase [Escherichia coli SE11], gi\|209914814\|dbj\|BAG... gi\|254290754, gi... - gi\|254290754\|ref\|YP_003056502.1\| acetyl-coenzyme A synthetase [Escherichia coli BL21(DE3)], gi\|25398... gi\|170083524, gi... - gi\|170083524\|ref\|YP_001732844.1\| acetyl-CoA synthetase [Escherichia coli str. K-12 substr. DH10B], g... gi\|226840180, gi... - gi\|254037074\|ref\|ZP_04871151.1\| acetyl-coenzyme A synthetase [Escherichia sp. 1_1_43], gi\|226840180\|...	0.0	[62..710]	[10..644]
gi\|167426184, gi... - gi\|167426184\|ref\|ZP_02317937.1\| acetate--CoA ligase [Yersinia pestis biovar Mediaevalis str. K197300... gi\|167468260 - gi\|167468260\|ref\|ZP_02332964.1\| acetate--CoA ligase [Yersinia pestis FV-1] ACSA_YERPE - Acetyl-coenzyme A synthetase OS=Yersinia pestis GN=acs PE=3 SV=2 gi\|165990673, gi... - gi\|166010583\|ref\|ZP_02231481.1\| acetate--CoA ligase [Yersinia pestis biovar Antiqua str. E1979001], ... gi\|166213894, gi... - gi\|166213894\|ref\|ZP_02239929.1\| acetate--CoA ligase [Yersinia pestis biovar Antiqua str. B42003004],... gi\|167048137, gi... - gi\|167402487\|ref\|ZP_02307942.1\| acetate--CoA ligase [Yersinia pestis biovar Antiqua str. UG05-0454],... gi\|229836504, gi... - gi\|229836504\|ref\|ZP_04456670.1\| acetyl-coenzyme A synthetase [Yersinia pestis Pestoides A], gi\|22970... gi\|167418710, gi... - gi\|167418710\|ref\|ZP_02310463.1\| acetate--CoA ligase [Yersinia pestis biovar Orientalis str. MG05-102... gi\|161511453 - gi\|161511453\|ref\|NP_991800.2\| acetyl-CoA synthetase [Yersinia pestis biovar Microtus str. 91001] gi\|229842194, gi... - gi\|229842194\|ref\|ZP_04462349.1\| acetyl-coenzyme A synthetase [Yersinia pestis biovar Orientalis str.... gi\|162354221, gi... - gi\|162421406\|ref\|YP_001608244.1\| acetyl-CoA synthetase [Yersinia pestis Angola], gi\|162354221\|gb\|ABX... gi\|229696479, gi... - gi\|229840113\|ref\|ZP_04460272.1\| acetyl-coenzyme A synthetase [Yersinia pestis biovar Orientalis str.... ACSA_YERPN - Acetyl-coenzyme A synthetase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=acs PE=3 SV=1 gi\|165921419, gi... - gi\|165926796\|ref\|ZP_02222628.1\| acetate--CoA ligase [Yersinia pestis biovar Orientalis str. F1991016... ACSA_YERPA - Acetyl-coenzyme A synthetase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=acs PE=3 SV=1 gi\|165936473, gi... - gi\|165936473\|ref\|ZP_02225041.1\| acetate--CoA ligase [Yersinia pestis biovar Orientalis str. IP275], ... gi\|218927458, gi... - gi\|218927458\|ref\|YP_002345333.1\| acetyl-CoA synthetase [Yersinia pestis CO92], gi\|16120590\|ref\|NP_40... gi\|150260700, gi... - gi\|150260700\|ref\|ZP_01917428.1\| acetyl-coenzyme A synthetase [Yersinia pestis CA88-4125], gi\|1492901... ACSA_YERPP - Acetyl-coenzyme A synthetase OS=Yersinia pestis (strain Pestoides F) GN=acs PE=3 SV=1	0.0	[54..710]	[1..644]
gi\|15804661, gi\|... - gi\|15804661\|ref\|NP_290702.1\| acetyl-CoA synthetase [Escherichia coli O157:H7 EDL933], gi\|12519026\|gb... gi\|217322623, gi... - gi\|217326402\|ref\|ZP_03442486.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. TW14588], gi\|2173... gi\|209751100, gi... - pir\|\|G86100 acetyl-CoA synthetase [imported] - Escherichia coli (strain O157:H7, substrain EDL933),... gi\|209161294, gi... - gi\|209399894\|ref\|YP_002273610.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4115], gi\|2091... gi\|208729342, gi... - gi\|208809541\|ref\|ZP_03251878.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4206], gi\|20872... gi\|195935854 - gi\|195935854\|ref\|ZP_03081236.1\| acetyl-CoA synthetase [Escherichia coli O157:H7 str. EC4024] gi\|208818900, gi... - gi\|208818900\|ref\|ZP_03259220.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4042], gi\|20873... gi\|208812711, gi... - gi\|208812711\|ref\|ZP_03254040.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4045], gi\|20873... gi\|168780486, gi... - gi\|189001801\|gb\|EDU70787.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4076], gi\|168780486... gi\|187769915, gi... - gi\|187769915\|gb\|EDU33759.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4196], gi\|168774431... gi\|189379155, gi... - gi\|189379155\|gb\|EDU97571.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC508], gi\|168798264\|... gi\|189375157, gi... - gi\|189375157\|gb\|EDU93573.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC869], gi\|168784689\|... gi\|189357553, gi... - gi\|189357553\|gb\|EDU75972.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4401], gi\|168755243... gi\|168748079, gi... - gi\|188017377\|gb\|EDU55499.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4113], gi\|168748079... ACSA_ECO57 - Acetyl-coenzyme A synthetase OS=Escherichia coli O157:H7 GN=acs PE=3 SV=1 gi\|168766333, gi... - gi\|189364237\|gb\|EDU82656.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4486], gi\|168766333... gi\|168760922, gi... - gi\|189368558\|gb\|EDU86974.1\| acetate--CoA ligase [Escherichia coli O157:H7 str. EC4501], gi\|168760922... gi\|15834305, gi\|... - gi\|15834305\|ref\|NP_313078.1\| acetyl-CoA synthetase [Escherichia coli O157:H7 str. Sakai], gi\|1336452... gi\|254796089, gi... - gi\|254796089\|ref\|YP_003080926.1\| acetyl-CoA synthetase [Escherichia coli O157:H7 str. TW14359], gi\|2...	0.0	[62..710]	[10..644]
ACSA_RHILO - Acetyl-coenzyme A synthetase OS=Rhizobium loti GN=acsA PE=3 SV=1 ACSA_RHILO - Acetyl-coenzyme A synthetase OS=Rhizobium loti (strain MAFF303099) GN=acsA PE=3 SV=1	0.0	[56..709]	[4..644]

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Predicted Domain #1

Region A:
Residues: [1-102]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPSAVQSSK LEEQSSEIDK LKAKMSQSAA TAQQKKEHEY EHLTSVKIVP QRPISDRLQP  60
   61 AIATHYSPHL DGLQDYQRLH KESIEDPAKF FGSKATQFLN WS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-sulfur bonds	5.10123876514454	bayes_pls_golite062009
fatty acid ligase activity	4.83067429373059	bayes_pls_golite062009
long-chain fatty acid-CoA ligase activity	4.72692389032116	bayes_pls_golite062009
acetate-CoA ligase activity	4.48129067128523	bayes_pls_golite062009
acid-thiol ligase activity	4.28278725989432	bayes_pls_golite062009
CoA-ligase activity	4.12850865352867	bayes_pls_golite062009
ligase activity	2.49556073715112	bayes_pls_golite062009
catalytic activity	1.83545185797733	bayes_pls_golite062009
binding	1.5312519256537	bayes_pls_golite062009
transporter activity	1.29780964436121	bayes_pls_golite062009
transmembrane transporter activity	1.07143339827205	bayes_pls_golite062009
acetoacetate-CoA ligase activity	1.03788694975627	bayes_pls_golite062009
substrate-specific transporter activity	1.03753946113449	bayes_pls_golite062009
protein binding	0.985225190358794	bayes_pls_golite062009
transcription regulator activity	0.950362540931728	bayes_pls_golite062009
AMP binding	0.778227294974491	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.54797726647835	bayes_pls_golite062009
adenyl ribonucleotide binding	0.519946577969422	bayes_pls_golite062009
adenyl nucleotide binding	0.500908589473269	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.464663038956639	bayes_pls_golite062009
luciferin monooxygenase activity	0.460892968031761	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.398310577427897	bayes_pls_golite062009
active transmembrane transporter activity	0.251681382273558	bayes_pls_golite062009
primary active transmembrane transporter activity	0.225448500718996	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.216579620878492	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.177812048124158	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.174283007890308	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.173963339749644	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0401881910649647	bayes_pls_golite062009
pyrophosphatase activity	0.0047964784091391	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [103-117]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPFDKVFIPD PKTGR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [387-574]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGTPAYPNYS RYWDIIDEHK VTQFYVAPTA LRLLKRAGDS YIENHSLKSL RCLGSVGEPI  60
   61 AAEVWEWYSE KIGKNEIPIV DTYWQTESGS HLVTPLAGGV TPMKPGSASF PFFGIDAVVL 120
  121 DPNTGEELNT SHAEGVLAVK AAWPSFARTI WKNHDRYLDT YLNPYPGYYF TGDGAAKDKD 180
  181 GYIWILGR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	277.218487
Match:	1amuA_
Description:	Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [118-168]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSFQNNAWFL NGQLNACYNC VDRHALKTPN KKAIIFEGDE PGQGYSITYK E

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [322-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSTGAPKGVQ HSTAGYLLGA LLTMRYTFDT HQEDVFFTAG DIGWITGHTY VVYGPLLYGC  60
   61 ATLVF

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [575-713]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDDVVNVSGH RLSTAEIEAA IIEDPIVAEC AVVGFNDDLT GQAVAAFVVL KNKSSWSTAT  60
   61 DDELQDIKKH LVFTVRKDIG PFAAPKLIIL VDDLPKTRSG KIMRRILRKI LAGESDQLGD 120
  121 VSTLSNPGIV RHLIDSVKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	277.218487
Match:	1amuA_
Description:	Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [169-321]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLEEVCQVAQ VLTYSMGVRK GDTVAVYMPM VPEAIITLLA ISRIGAIHSV VFAGFSSNSL  60
   61 RDRINDGDSK VVITTDESNR GGKVIETKRI VDDALRETPG VRHVLVYRKT NNPSVAFHAP 120
  121 RDLDWATEKK KYKTYYPCTP VDSEDPLFLL YTS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	277.218487
Match:	1amuA_
Description:	Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: