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Protein Overview: ACS1_YEAST

General Information:
Name(s) found: ACS1_YEAST [Swiss-Prot]
Description(s) found:
  • Acetyl-coenzyme A synthetase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACS1 PE=1 SV=2 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 713 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPSAVQSSK LEEQSSEIDK LKAKMSQSAA TAQQKKEHEY EHLTSVKIVP QRPISDRLQP  60
   61 AIATHYSPHL DGLQDYQRLH KESIEDPAKF FGSKATQFLN WSKPFDKVFI PDPKTGRPSF 120
  121 QNNAWFLNGQ LNACYNCVDR HALKTPNKKA IIFEGDEPGQ GYSITYKELL EEVCQVAQVL 180
  181 TYSMGVRKGD TVAVYMPMVP EAIITLLAIS RIGAIHSVVF AGFSSNSLRD RINDGDSKVV 240
  241 ITTDESNRGG KVIETKRIVD DALRETPGVR HVLVYRKTNN PSVAFHAPRD LDWATEKKKY 300
  301 KTYYPCTPVD SEDPLFLLYT SGSTGAPKGV QHSTAGYLLG ALLTMRYTFD THQEDVFFTA 360
  361 GDIGWITGHT YVVYGPLLYG CATLVFEGTP AYPNYSRYWD IIDEHKVTQF YVAPTALRLL 420
  421 KRAGDSYIEN HSLKSLRCLG SVGEPIAAEV WEWYSEKIGK NEIPIVDTYW QTESGSHLVT 480
  481 PLAGGVTPMK PGSASFPFFG IDAVVLDPNT GEELNTSHAE GVLAVKAAWP SFARTIWKNH 540
  541 DRYLDTYLNP YPGYYFTGDG AAKDKDGYIW ILGRVDDVVN VSGHRLSTAE IEAAIIEDPI 600
  601 VAECAVVGFN DDLTGQAVAA FVVLKNKSSW STATDDELQD IKKHLVFTVR KDIGPFAAPK 660
  661 LIILVDDLPK TRSGKIMRRI LRKILAGESD QLGDVSTLSN PGIVRHLIDS VKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] MSA 3.509997 View MSA. No confident structure predictions are available.
    2 View Details [103..117]
    [387..574]    		 PSI-BLAST 277.218487 Phenylalanine activating domain of gramicidin synthetase 1
    3 View Details [118..168]
    [322..386]
    [575..713]    		 PSI-BLAST 277.218487 Phenylalanine activating domain of gramicidin synthetase 1
    4 View Details [169..321] PSI-BLAST 277.218487 Phenylalanine activating domain of gramicidin synthetase 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming carbon-sulfur bonds
    		•  5.10123876514454 bayes_pls_golite062009
  • fatty acid ligase activity
    		•  4.83067429373059 bayes_pls_golite062009
  • long-chain fatty acid-CoA ligase activity
    		•  4.72692389032116 bayes_pls_golite062009
  • acetate-CoA ligase activity
    		•  4.48129067128523 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  4.28278725989432 bayes_pls_golite062009
  • CoA-ligase activity
    		•  4.12850865352867 bayes_pls_golite062009
  • ligase activity
    		•  2.49556073715112 bayes_pls_golite062009
  • catalytic activity
    		•  1.83545185797733 bayes_pls_golite062009
  • binding
    		•  1.5312519256537 bayes_pls_golite062009
  • transporter activity
    		•  1.29780964436121 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07143339827205 bayes_pls_golite062009
  • acetoacetate-CoA ligase activity
    		•  1.03788694975627 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.03753946113449 bayes_pls_golite062009
  • protein binding
    		•  0.985225190358794 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.950362540931728 bayes_pls_golite062009
  • AMP binding
    		•  0.778227294974491 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.54797726647835 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.519946577969422 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.500908589473269 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.464663038956639 bayes_pls_golite062009
  • luciferin monooxygenase activity
    		•  0.460892968031761 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.398310577427897 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.251681382273558 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.225448500718996 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.216579620878492 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.177812048124158 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.174283007890308 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.173963339749644 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0401881910649647 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0047964784091391 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle