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Protein Overview: gi|194420903, gi...

General Information:
Name(s) found: gi|83584518 [NCBI NR]
gi|194440160 [NCBI NR]
gi|194420903 [NCBI NR]
Description(s) found:
Found 4 descriptions.
SHOW ALL
  • gi|83584518|ref|ZP_00923195.1| COG0749: DNA polymerase I - 3'-5' exonuclease and polymerase domains [Escherichia coli 101-1] [NCBI NR]
  • gi|194440160|ref|ZP_03072207.1| DNA polymerase I [Escherichia coli 101-1] [NCBI NR]
  • gi|194420903|gb|EDX36943.1| DNA polymerase I [Escherichia coli 101-1] [NCBI NR]
    • Organism: Escherichia coli 101-1
    Length: 928 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQIPQNPLI LVDGSSYLYR AYHAFPPLTN SAGEPTGAMY GVLNMLRSLI MQYKPTHAAV  60
   61 VFDAKGKTFR DELFEHYKSH RPPMPDDLRA QIEPLHAMVK AMGLPLLAVS GVEADDVIGT 120
  121 LAREAEKAGR PVLISTGDKD MAQLVTPNIT LINTMTNTIL GPEEVVNKYG VPPELIIDFL 180
  181 ALMGDSSDNI PGVPGVGEKT AQALLQGLGG LDTLYAEPEK IAGLSFRGAK TMAAKLEQNK 240
  241 EVAYLSYQLA TIKTDVELEL TCEQLEVQQP AAEELLGLFK KYEFKRWTAD VEAGKWLQAK 300
  301 GAKPAAKPQE TSVADEAPEV TATVISYDNY VTILDEETLK AWIAKLEKAP VFAFDTETDS 360
  361 LDNISANLVG LSFAIEPGVA AYIPVAHDYL DAPDQISRER ALELLKPLLE DEKALKVGQN 420
  421 LKYDRGILAN YGIELRGIAF DTMLESYILN SVAGRHDMDS LAERWLKHKT ITFEEIAGKG 480
  481 KNQLTFNQIA LEEAGRYAAE DADVTLQLHL KMWPDLQKHK GPLNVFENIE MPLVPVLSRI 540
  541 ERNGVKIDPK VLHNHSEELT LRLAELEKKA HEIAGEEFNL SSTKQLQTIL FEKQGIKPLK 600
  601 KTPGGAPSTS EEVLEELALD YPLPKVILEY RGLAKLKSTY TDKLPLMINP KTGRVHTSYH 660
  661 QAVTATGRLS STDPNLQNIP VRNEEGRRIR QAFIAPEDYV IVSADYSQIE LRIMAHLSRD 720
  721 KGLLTAFAEG KDIHRATAAE VFGLPLETVT SEQRRSAKAI NFGLIYGMSA FGLARQLNIP 780
  781 RKEAQKYMDL YFERYPGVLE YMERTRAQAK EQGYVETLDG RRLYLPDIKS SNGARRAAAE 840
  841 RAAINAPMQG TAADIIKRAM IAVDAWLQAE QPRVRMIMQV HDELVFEVHK DDVDAVAKQI 900
  901 HQLMENCTRL DVPLLVEVGS GENWDQAH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..316] PSI-BLAST 42.30103 Crystal structure of the human FEN1-PCNA complex
    2 View Details [317..928] PSI-BLAST 1000.0 STRUCTURE OF LARGE FRAGMENT OF ESCHERICHIA COLI DNA POLYMERASE I COMPLEXED WITH D/TMP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  6.33250010226773 bayes_pls_golite062009
  • DNA polymerase activity
    		•  6.29823284530384 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  4.44991185075403 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  4.07340135619133 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  4.00347149381256 bayes_pls_golite062009
  • exonuclease activity
    		•  3.72933728353267 bayes_pls_golite062009
  • endonuclease activity
    		•  3.34452870782409 bayes_pls_golite062009
  • flap endonuclease activity
    		•  3.33299970358696 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  3.0212856936199 bayes_pls_golite062009
  • hydrolase activity
    		•  2.80884894948531 bayes_pls_golite062009
  • nuclease activity
    		•  2.68985366534382 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  2.66071760609476 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  2.59274910747636 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  2.50398903419616 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  2.49591627688404 bayes_pls_golite062009
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
    		•  2.35681599762087 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.30898087880859 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.81733387652368 bayes_pls_golite062009
  • transferase activity
    		•  1.74257249090689 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  1.57727010389968 bayes_pls_golite062009
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  1.4168915851726 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  1.37762008199118 bayes_pls_golite062009
  • catalytic activity
    		•  1.37534898662234 bayes_pls_golite062009
  • 5'-flap endonuclease activity
    		•  1.1643154824625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.15438701346212 bayes_pls_golite062009
  • DNA binding
    		•  0.977616139642209 bayes_pls_golite062009
  • binding
    		•  0.835604503331911 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.632303740950726 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.620251812982006 bayes_pls_golite062009
  • single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
    		•  0.547465794501352 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.325190032018196 bayes_pls_golite062009
  • protein binding
    		•  0.236485289446406 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.00329622574140309 bayes_pls_golite062009
    2
    Term Confidence Notes
  • DNA polymerase activity
    		•  7.87431862983329 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  7.78411937387917 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  5.3880945520411 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.97887080014447 bayes_pls_golite062009
  • exonuclease activity
    		•  2.86892175148145 bayes_pls_golite062009
  • nuclease activity
    		•  2.84202779131927 bayes_pls_golite062009
  • hydrolase activity
    		•  2.78602644579272 bayes_pls_golite062009
  • endonuclease activity
    		•  2.57451891632839 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.43032491532703 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.94077739152313 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.87431870698721 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.87430802282815 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.78601534260605 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.6669463825155 bayes_pls_golite062009
  • transferase activity
    		•  1.47288345517763 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  1.22355734630669 bayes_pls_golite062009
  • endoribonuclease activity
    		•  1.13158139596857 bayes_pls_golite062009
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
    		•  0.91511342646401 bayes_pls_golite062009
  • ribonuclease H activity
    		•  0.869940880547909 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.782108781904855 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.77421125364834 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.64268174969672 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.251640316483416 bayes_pls_golite062009
  • binding
    		•  0.122249780594036 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle