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Protein Overview: CG12877-PC

General Information:
Name(s) found: CG12877-PC / FBpp0099868 [FlyBase]
Description(s) found:
Found 16 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG12877 (CG12877, FBgn0039544). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:23532824..23536579. It has the cytological map location 98B2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: exonuclease activity; nucleic acid binding. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 991 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: NONE FOUND
    Molecular Function: nucleic acid binding [IEA]
    exonuclease activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPSTGLFKG FLCPYFDGQD AASCKRPFCH FKHARKDELE AAPPAEPSPV PKYKPAPKLL  60
   61 SLPLPQITLC APRKKSNLEY HPEKPALDAS PAKKKQEASV DSAPKYVPGQ PSVTNGEEYD 120
  121 DWQAVLEKEI DEQMQVEIEE QVQNNDEEQK IDTVAENEED QENTQLTDAR DSHEKDRKPS 180
  181 KERERDIEKK KIRELKREKI KDRDRDRDRD REKDKEKSKE RDREKEKNDR DKRKSSHSDK 240
  241 ERSKERNTSS SSSSKHKSSS SSSSSKKSSS SDKHRDDKSS SSRHKSSSSS SSSKSHHHKS 300
  301 SSSSSRSKTK RSSSSSKSAG TSKSEPEADK DTEAAVLTPA EPMDDLDDMD FDFEADTSEG 360
  361 EIVRQCEMIF DEMEKKFAQM HKDEGGNANP ESSRKRKAPS PDIDTFTEAA TAALQKRRVA 420
  421 HENADKITPH LAPSAAMRKP NHVRNAMQAI FNRRAELRRQ EKLQAEASAE QVRQAQERVR 480
  481 QAQEELRQAK VNSNLTPLIS RSALTPPVRS ARSIAPVANI VAIARAKKKI EELQAEKKPA 540
  541 FTPAQSFKGA GRVAHKPTAA LDKAAPVSNA EKPTVLDPSS SKISYNVRIQ YYEMMVRHCT 600
  601 VIYPQLADAW ERAQVEELTV FKKCNTPAIY KNSCMLAINK LRKEALEAGN KPSVACKTVS 660
  661 HEMMLGGKRA LTTSWSVEKK GKLSSLGNGE PFDALDAEKA YKMVFDLRLT EEQLVENGYP 720
  721 RPGDKRGSAV IRACRPNRRP NQKERYCSRC GKVFSLDIYE HQSFDMCNYH PKSTGYRRGF 780
  781 TDHQHRCCQQ PAGTPGCTYA NYHVSDYYDP EKLTCFVKTI ERGEEFVPTK KDIYALDCEM 840
  841 CYTTHGIELT RVTVVDINGR SVYDALVKPD NQIVDYNTTY SGITEAMLSN ETRTIRDVQA 900
  901 VLMSMFHAKT VLVGHSLESD LKALKLIHDV VVDTSVLFPH KMGPPKKRAL KTLCIENLKR 960
  961 IIQESEAGHD SAEDAEVCIQ LIKYYLRNKI S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..387] PSI-BLAST 19.30103 Heavy meromyosin subfragment
    2 View Details [388..559] FFAS03 1.05 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    3 View Details [560..739] deduced N/A No confident structure predictions are available.
    4 View Details [740..822] FFAS03 0.958 Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa
    5 View Details [823..991] PSI-BLAST 44.69897 human ISG20

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • nucleic acid binding
    		•  3.44273032731825 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.37529385176635 bayes_pls_golite062009
  • DNA binding
    		•  3.3049326844117 bayes_pls_golite062009
  • transcription factor activity
    		•  2.44389510173662 bayes_pls_golite062009
  • binding
    		•  2.40458515823407 bayes_pls_golite062009
  • protein binding
    		•  2.08585763522196 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.57041104288348 bayes_pls_golite062009
  • transcription activator activity
    		•  1.39704874290301 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.33097016250582 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.00239065862819 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.873177180199469 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.732558534458316 bayes_pls_golite062009
  • transcription factor binding
    		•  0.691846986886118 bayes_pls_golite062009
  • chromatin binding
    		•  0.626365497850853 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.297902921051953 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.200483461579207 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.113925660147477 bayes_pls_golite062009
    5
    Term Confidence Notes
  • ribonuclease activity
    		•  5.30591758406946 bayes_pls_golite062009
  • exoribonuclease activity
    		•  3.71639182685131 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  3.59362615133405 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  3.1992647486402 bayes_pls_golite062009
  • exonuclease activity
    		•  3.13676176369406 bayes_pls_golite062009
  • nuclease activity
    		•  3.11657409772275 bayes_pls_golite062009
  • ribonuclease H activity
    		•  2.91966688044755 bayes_pls_golite062009
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
    		•  2.75003136922541 bayes_pls_golite062009
  • endonuclease activity
    		•  2.63074055051349 bayes_pls_golite062009
  • endoribonuclease activity
    		•  2.59247838057313 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.57498413015114 bayes_pls_golite062009
  • hydrolase activity
    		•  2.41899414621161 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  2.04408785855894 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  1.44123900197846 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.23371034593624 bayes_pls_golite062009
  • protein binding
    		•  1.16870279238939 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.1219517187744 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.10433412699603 bayes_pls_golite062009
  • DNA binding
    		•  0.860359347662869 bayes_pls_golite062009
  • binding
    		•  0.762139256580538 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.717600245625866 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.708753843279937 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.598360955770972 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.568273228950698 bayes_pls_golite062009
    		• 0.49473250705373 bayes_pls_golite062009
  • transcription factor activity
    		•  0.332903382446869 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.278838342302102 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.261428436029202 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0701825322473915 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.00214157813118243 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle