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View Structure Prediction Details

Protein: CG12877-PC
Organism: Drosophila melanogaster
Length: 991 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG12877-PC.

Description E-value Query
Range		 Subject
Range
gi|73987536 - gi|73987536|ref|XP_533958.2| PREDICTED: similar to transcription elongation factor B polypeptide 3 b...
 458.0 [0..157] [989..826]

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Predicted Domain #1
Region A:
Residues: [1-387] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPSTGLFKG FLCPYFDGQD AASCKRPFCH FKHARKDELE AAPPAEPSPV PKYKPAPKLL  60
   61 SLPLPQITLC APRKKSNLEY HPEKPALDAS PAKKKQEASV DSAPKYVPGQ PSVTNGEEYD 120
  121 DWQAVLEKEI DEQMQVEIEE QVQNNDEEQK IDTVAENEED QENTQLTDAR DSHEKDRKPS 180
  181 KERERDIEKK KIRELKREKI KDRDRDRDRD REKDKEKSKE RDREKEKNDR DKRKSSHSDK 240
  241 ERSKERNTSS SSSSKHKSSS SSSSSKKSSS SDKHRDDKSS SSRHKSSSSS SSSKSHHHKS 300
  301 SSSSSRSKTK RSSSSSKSAG TSKSEPEADK DTEAAVLTPA EPMDDLDDMD FDFEADTSEG 360
  361 EIVRQCEMIF DEMEKKFAQM HKDEGGN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.30103
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [388-559] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANPESSRKRK APSPDIDTFT EAATAALQKR RVAHENADKI TPHLAPSAAM RKPNHVRNAM  60
   61 QAIFNRRAEL RRQEKLQAEA SAEQVRQAQE RVRQAQEELR QAKVNSNLTP LISRSALTPP 120
  121 VRSARSIAPV ANIVAIARAK KKIEELQAEK KPAFTPAQSF KGAGRVAHKP TA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.05
Match: 1h1kI
Description: THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [560-739] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALDKAAPVSN AEKPTVLDPS SSKISYNVRI QYYEMMVRHC TVIYPQLADA WERAQVEELT  60
   61 VFKKCNTPAI YKNSCMLAIN KLRKEALEAG NKPSVACKTV SHEMMLGGKR ALTTSWSVEK 120
  121 KGKLSSLGNG EPFDALDAEK AYKMVFDLRL TEEQLVENGY PRPGDKRGSA VIRACRPNRR 180
  181

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [740-822] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNQKERYCSR CGKVFSLDIY EHQSFDMCNY HPKSTGYRRG FTDHQHRCCQ QPAGTPGCTY  60
   61 ANYHVSDYYD PEKLTCFVKT IER

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.958
Match: 1zu1A
Description: Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.44273032731825 bayes_pls_golite062009
transcription regulator activity 3.37529385176635 bayes_pls_golite062009
DNA binding 3.3049326844117 bayes_pls_golite062009
transcription factor activity 2.44389510173662 bayes_pls_golite062009
binding 2.40458515823407 bayes_pls_golite062009
protein binding 2.08585763522196 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.57041104288348 bayes_pls_golite062009
transcription activator activity 1.39704874290301 bayes_pls_golite062009
structure-specific DNA binding 1.33097016250582 bayes_pls_golite062009
double-stranded DNA binding 1.00239065862819 bayes_pls_golite062009
transcription repressor activity 0.873177180199469 bayes_pls_golite062009
sequence-specific DNA binding 0.732558534458316 bayes_pls_golite062009
transcription factor binding 0.691846986886118 bayes_pls_golite062009
chromatin binding 0.626365497850853 bayes_pls_golite062009
transcription coactivator activity 0.297902921051953 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.200483461579207 bayes_pls_golite062009
transcription cofactor activity 0.113925660147477 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [823-991] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEEFVPTKKD IYALDCEMCY TTHGIELTRV TVVDINGRSV YDALVKPDNQ IVDYNTTYSG  60
   61 ITEAMLSNET RTIRDVQAVL MSMFHAKTVL VGHSLESDLK ALKLIHDVVV DTSVLFPHKM 120
  121 GPPKKRALKT LCIENLKRII QESEAGHDSA EDAEVCIQLI KYYLRNKIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.69897
Match: 1wljA
Description: human ISG20
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ribonuclease activity 5.30591758406946 bayes_pls_golite062009
exoribonuclease activity 3.71639182685131 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 3.59362615133405 bayes_pls_golite062009
3'-5'-exoribonuclease activity 3.1992647486402 bayes_pls_golite062009
exonuclease activity 3.13676176369406 bayes_pls_golite062009
nuclease activity 3.11657409772275 bayes_pls_golite062009
ribonuclease H activity 2.91966688044755 bayes_pls_golite062009
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity 2.75003136922541 bayes_pls_golite062009
endonuclease activity 2.63074055051349 bayes_pls_golite062009
endoribonuclease activity 2.59247838057313 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.57498413015114 bayes_pls_golite062009
hydrolase activity 2.41899414621161 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.04408785855894 bayes_pls_golite062009
3'-5' exonuclease activity 1.44123900197846 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
nucleic acid binding 1.23371034593624 bayes_pls_golite062009
protein binding 1.16870279238939 bayes_pls_golite062009
deoxyribonuclease activity 1.1219517187744 bayes_pls_golite062009
transcription regulator activity 1.10433412699603 bayes_pls_golite062009
DNA binding 0.860359347662869 bayes_pls_golite062009
binding 0.762139256580538 bayes_pls_golite062009
DNA polymerase activity 0.717600245625866 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.708753843279937 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.598360955770972 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.568273228950698 bayes_pls_golite062009
0.49473250705373 bayes_pls_golite062009
transcription factor activity 0.332903382446869 bayes_pls_golite062009
exodeoxyribonuclease activity 0.278838342302102 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.261428436029202 bayes_pls_golite062009
structure-specific DNA binding 0.0701825322473915 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.00214157813118243 bayes_pls_golite062009
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