Protein Overview: nas-28

General Information:
Name(s) found:	nas-28 / CE38958 [WormBase]
Description(s) found: Found 17 descriptions. SHOW ALL	WBGene00003546 locus:nas-28 Zinc metalloproteinase nas-28 status:Partially_confirmed UniProt:P98061 protein_id:CCD65318.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	497 amino acids
Gene Ontology:
Cellular Component:	membrane [IEA]
Biological Process:	proteolysis [IEA]
Molecular Function:	meprin A activity [IEA] zinc ion binding [IEA] astacin activity [IEA] metallopeptidase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFFPVVFFIP FVLGAPTQKA LEKILVDNNP DSVTNREKIR GIIDKAFENR VPRVQGRQGV  60
   61 APPVTFAALN YGPKNNQTKK FEELNQDINE YTFESDIMLN EKQAKHIATA IENGNYRSKR 120
  121 QAIVDTTNFW SVSVPIFYQF DTKLSATNIA NVRKAIQFWN DNSCLSFKED NNAKNRLFLS 180
  181 SAGGCWSYVG KQVDMPYQMV SVGPNCDTFG TATHELMHAI GFWHQQSRAD RDNYVYVDFS 240
  241 NIIPSQAYNF QKMAVDQAQL LNLPYDYGSV MQYYPYAFAV DSSKYTILAK ENGFQNSMGQ 300
  301 REAPAFSDII GVNKLYNCTS QCKIQMKCSN CGITDSRNCN QCKCPRYFTG ASCDSLPSGT 360
  361 APNCNGAVLQ ATSSWETFDA KAGDPSSFSS STDNSTNCYW HIKAPEGQQI EFKMTKTPLA 420
  421 AICMQECPWQ SIEVNLGKFD LFGMITCCDT ILNQVFTSEL NMIALRGIIR YNQLTFSIQY 480
  481 RAVPSSKPAS TNACLNQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..76]	deduced	N/A	No confident structure predictions are available.
2	View Details	[77..222]	PSI-BLAST	36.045757	STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
3	View Details	[223..497]	PSI-BLAST	31.0	Mannose-binding protein associated serine protease 2, MASP2

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

No functions predicted.

3

Term	Confidence	Notes
peptidase activity	2.03786631670095	bayes_pls_golite062009
receptor binding	1.94948331803509	bayes_pls_golite062009
receptor activity	1.17703206127603	bayes_pls_golite062009
hydrolase activity	1.12447587972667	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	1.10435298721188	bayes_pls_golite062009
endopeptidase activity	1.03668892056053	bayes_pls_golite062009
ErbB-3 class receptor binding	1.02450424977847	bayes_pls_golite062009
ErbB-2 class receptor binding	0.728290475143461	bayes_pls_golite062009
binding	0.708339313156457	bayes_pls_golite062009
metallopeptidase activity	0.623476257655953	bayes_pls_golite062009
epidermal growth factor receptor binding	0.58090527719405	bayes_pls_golite062009
metalloendopeptidase activity	0.508669171144608	bayes_pls_golite062009
protein binding	0.475826109910145	bayes_pls_golite062009
transcription factor binding	0.30492109086541	bayes_pls_golite062009
signal transducer activity	0.266830350139867	bayes_pls_golite062009
molecular transducer activity	0.266830350139867	bayes_pls_golite062009
growth factor activity	0.190406928940325	bayes_pls_golite062009
catalytic activity	0.075748351866431	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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