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View Structure Prediction Details

Protein: nas-28
Organism: Caenorhabditis elegans
Length: 497 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nas-28.

Description E-value Query
Range
Subject
Range
BP10_PARLI - Blastula protease 10 OS=Paracentrotus lividus GN=BP10 PE=2 SV=1
314.0 [0..40] [483..13]

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Predicted Domain #1
Region A:
Residues: [1-76]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFFPVVFFIP FVLGAPTQKA LEKILVDNNP DSVTNREKIR GIIDKAFENR VPRVQGRQGV  60
   61 APPVTFAALN YGPKNN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [77-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTKKFEELNQ DINEYTFESD IMLNEKQAKH IATAIENGNY RSKRQAIVDT TNFWSVSVPI  60
   61 FYQFDTKLSA TNIANVRKAI QFWNDNSCLS FKEDNNAKNR LFLSSAGGCW SYVGKQVDMP 120
  121 YQMVSVGPNC DTFGTATHEL MHAIGF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.045757
Match: 1astA
Description: STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [223-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WHQQSRADRD NYVYVDFSNI IPSQAYNFQK MAVDQAQLLN LPYDYGSVMQ YYPYAFAVDS  60
   61 SKYTILAKEN GFQNSMGQRE APAFSDIIGV NKLYNCTSQC KIQMKCSNCG ITDSRNCNQC 120
  121 KCPRYFTGAS CDSLPSGTAP NCNGAVLQAT SSWETFDAKA GDPSSFSSST DNSTNCYWHI 180
  181 KAPEGQQIEF KMTKTPLAAI CMQECPWQSI EVNLGKFDLF GMITCCDTIL NQVFTSELNM 240
  241 IALRGIIRYN QLTFSIQYRA VPSSKPASTN ACLNQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.0
Match: 1nt0A
Description: Mannose-binding protein associated serine protease 2, MASP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 2.03786631670095 bayes_pls_golite062009
receptor binding 1.94948331803509 bayes_pls_golite062009
receptor activity 1.17703206127603 bayes_pls_golite062009
hydrolase activity 1.12447587972667 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.10435298721188 bayes_pls_golite062009
endopeptidase activity 1.03668892056053 bayes_pls_golite062009
ErbB-3 class receptor binding 1.02450424977847 bayes_pls_golite062009
ErbB-2 class receptor binding 0.728290475143461 bayes_pls_golite062009
binding 0.708339313156457 bayes_pls_golite062009
metallopeptidase activity 0.623476257655953 bayes_pls_golite062009
epidermal growth factor receptor binding 0.58090527719405 bayes_pls_golite062009
metalloendopeptidase activity 0.508669171144608 bayes_pls_golite062009
protein binding 0.475826109910145 bayes_pls_golite062009
transcription factor binding 0.30492109086541 bayes_pls_golite062009
signal transducer activity 0.266830350139867 bayes_pls_golite062009
molecular transducer activity 0.266830350139867 bayes_pls_golite062009
growth factor activity 0.190406928940325 bayes_pls_golite062009
catalytic activity 0.075748351866431 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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