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Protein Overview: clp-1

General Information:
Name(s) found: clp-1 / CE37743 [WormBase]
Description(s) found:
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  • WBGene00000542 locus:clp-1 Calpain clp-1 status:Confirmed UniProt:P34308 protein_id:CCD63432.1 [WormBase]
  • gi|71981301|ref|NP_498741.3| CaLPain family member (clp-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|68837480|sp|P34308.4|CAN_CAEEL RecName: Full=Calpain clp-1 [NCBI NR]
  • gi|55710080|gb|AAV58887.1| Calpain family protein 1, isoform a [Caenorhabditis elegans] [NCBI NR]
  • Calpain clp-1 OS=Caenorhabditis elegans GN=clp-1 PE=3 SV=4 [Swiss-Prot]
  • CE37743 WBGene00000542 locus:clp-1 Calpain status:Confirmed SW:P34308 protein_id:AAV58887.1 [wormpep150.fasta]
  • 37743 WBGene00000542 locus:clp-1 Calpain status:Confirmed SW:P34308 protein_id:AAV58887.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE37743 WBGene00000542 locus:clp-1 Calpain status:Confirmed protein_id:AAV58887.1 [WormBase_C-elegans_na_01-20-2005_combined_reversed.fasta]
  • CE37743 WBGene00000542 locus:clp-1 Calpain status:Confirmed UniProt:P34308 protein_id:AAV58887.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE37743 WBGene00000542 locus:clp-1 Calpain status:Confirmed UniProt:P34308 protein_id:AAV58887.1| [wormORF-contam.fasta]
  • CaLPain family member (clp-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Calpain clp-1 [nr-271106-contam.fasta]
  • Calpain family protein 1, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE37743 WBGene00000542 locus:clp-1 Calpain status:Confirmed UniProt:P34308 protein_id:CCD63432.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE37743 WBGene00000542 locus:clp-1 status:Confirmed UniProt:P34308 protein_id:CCD63432.1 Calpain clp-1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 780 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEALink to PubMed article]
    intracellular [IEALink to PubMed article]
    Biological Process: cell death [IMPLink to PubMed article]
    proteolysis [IEALink to PubMed article]
    Molecular Function: cysteine-type endopeptidase activity [IEALink to PubMed article]
    calcium-dependent cysteine-type endopeptidase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADDEEEIIQ KVEVKPDEFN GLIGSIAGNL IRDKVGGAGG DILGGLASNF FGGGGGGGGG  60
   61 GGGGGFGGGN GGFGGGSNYD QGGNGNSGDQ QKRKRDMAKD LIGGIFDNVV NRKGKKEQDN 120
  121 YGGGGNYGGG GGNQGGGGGG GFNFNDIGGL INSMGGGGGG GQRQGGGGGG FGDILGGIGS 180
  181 LIGGGGGGQY NGGGGNVNPN NLNGGMVNVI GNLIGEAAHR FLGVDPGTGR IIGAVAGNVI 240
  241 MGLGGKDNSL GNIGKVILDN IISGKFRRDV DPFVRPGPDP DRGGGGSGPS PISPRPTTEP 300
  301 QDFYELRDQC LESKRLFEDP QFLANDSSLF FSKRPPKRVE WLRPGEITRE PQLITEGHSR 360
  361 FDVIQGELGD CWLLAAAANL TLKDELFYRV VPPDQSFTEN YAGIFHFQFW QYGKWVDVVI 420
  421 DDRLPTSNGE LLYMHSASNN EFWSALLEKA YAKLFGSYEA LKGGTTSEAL EDMTGGLTEF 480
  481 IDLKNPPRNL MQMMMRGFEM GSLFGCSIEA DPNVWEAKMS NGLVKGHAYS ITGCRIVDGP 540
  541 NGQTCILRIR NPWGNEQEWN GPWSDNSREW RSVPDSVKQD MGLKFDHDGE FWMSFDDFMR 600
  601 NFEKMEICNL GPDVMDEVYQ MTGVKAAGMV WAANTHDGAW VRNQTAGGCR NYINTFANNP 660
  661 QFRVQLTDSD PDDDDELCTV IFAVLQKYRR NLKQDGLDNV PIGFAVYDAG NNRGRLSKQF 720
  721 FAANKSAMRS AAFINLREMT GRFRVPPGNY VVVPSTFEPN EEAEFMLRVY TNGFIESEEL 780
  781

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..254] PSI-BLAST 17.39794 No description for 2quaA was found.
    2 View Details [255..320] deduced N/A No confident structure predictions are available.
    3 View Details [321..780] PSI-BLAST 163.0 Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • peptidase activity
    		•  3.19059336788201 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  3.05412701733177 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.93596559605971 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.91734319991078 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43328552376748 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • protein binding
    		•  1.92445772322782 bayes_pls_golite062009
  • binding
    		•  1.92046698500094 bayes_pls_golite062009
  • transporter activity
    		•  1.21845572420504 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.19670958990587 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.07520173658976 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.00091316610003 bayes_pls_golite062009
  • signal transducer activity
    		•  0.9347662946007 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.9347662946007 bayes_pls_golite062009
  • calcium ion binding
    		•  0.687204894708051 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.495368836247989 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.484449686814032 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.354062437867002 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.313326619937245 bayes_pls_golite062009
  • DNA binding
    		•  0.306964954191276 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.246369226539662 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.193338880082314 bayes_pls_golite062009
  • tubulin binding
    		•  0.11107511867058 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle