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Protein Overview: Dys-PE

General Information:
Name(s) found: Dys-PE / FBpp0110216 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Dystrophin is referred to in FlyBase by the symbol Dmel\Dys (CG34157, FBgn0260003). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15286810..15421117. It has the cytological map location 92A5-92A10. There is experimental evidence that it has the molecular function</span>: WW domain binding. There is experimental evidence that it is involved in the biological process</span>: neuromuscular synaptic transmission; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; regulation of short-term neuronal synaptic plasticity; muscle homeostasis; establishment of cell polarity. 39 alleles are reported. The phenotypes of these alleles are annotated with: posterior crossvein; presynaptic active zone; terminal button. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1051 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [ISS]
    dystrophin-associated glycoprotein complex [IPI][ISS][NAS]
    Biological Process: muscle organ development [ISS]
    muscle cell homeostasis [IMP]
    neuromuscular synaptic transmission [IDA]
    establishment of cell polarity [IMP]
    imaginal disc-derived wing vein morphogenesis [IMP]
    imaginal disc-derived wing vein specification [IMP]
    regulation of short-term neuronal synaptic plasticity [IDA]
    Molecular Function: zinc ion binding [IEA]
    structural constituent of muscle [ISS]
    actin binding [ISS]
    calcium ion binding [IEA]
    structural molecule activity [ISS]
    structural constituent of cytoskeleton [ISS]
    cytoskeletal protein binding [ISS]
    WW domain binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLFASSGQA ATSPALAHSS SDEAGEVIEN SHTKRAGCSV LQSSGGKSRS LERYSGAPKI  60
   61 HQQTLEMLPP YATPTCSTRR RLLAPFRSLK RRSRSSSSSN ESHHFGNHLN NLVVVNVGAA 120
  121 AANGGVAKAK AKASSQSGDS GTGGTELEHE MEQDDDEEDE EEGEEMDELS LSYSQLSSSG 180
  181 CEEAEAPPED VPDDRQAAVE ATVSACVQHV ANERRRNILS LYSSSSEEQL HCRLGDITLV 240
  241 DDTYSNYDPQ NDAERMFLQV VGILRDENEK MRQFQKILED LSSRVALAEQ TKTSWLPPSS 300
  301 VGEANEQMQQ LQRLRDKMTT ASALLDDCNE QQSFFTANQV LVPTPCLSKL EDLNTRMKLL 360
  361 QIAMDERQKV LCQAGAQQTH ENGDDGRTTS NSGTIGPLPN LGQSVKPPWE RATTAANVPY 420
  421 YIDHERETTH WDHPEMIELM KGLADLNEIR FSAYRTAMKL RSVQKRLALD RISMSTACES 480
  481 FDRHGLRAQN DKLIDIPDMT TVLHSLYVTI DKIDLTLMLD LAINWILNVY DSQRTGQIRV 540
  541 LSFKVGLVLL CKGHLEEKYR YLFRLVADTD RRADQRRLGL LLHDCIQVPR QLGEVAAFGG 600
  601 SNIEPSVRSC LEQAGISQEA IDGNQDISIE LQHFLGWLQH EPQSLVWLPV LHRLAAAEAA 660
  661 KHQAKCNICK EYPIVGFRYR CLKCFNFDMC QKCFFFGRNA KNHKLTHPMH EYCTTTTSTE 720
  721 DVRDFTRALK NKFKSRKYFK KHPRVGYLPV QSVLEGDALE SPAPSPQHTT HQLQNDMHSR 780
  781 LEMYASRLAQ VEYGGTGSNS TPDSDDEHQL IAQYCQALPG TSNGSAPKSP VQVMAAMDAE 840
  841 QREELEAIIR DLEEENANLQ AEYQQLCSKE QSGMPEDSNG MQHSSSSMTG LSGQGEQGQD 900
  901 MMAEAKLLRQ HKGRLEARMQ ILEDHNRQLE AQLQRLRQLL DEPNGGGSSA TSSGLPSAPG 960
  961 SALNSKPNTL QTRSVTASQL NTDSPAKMNQ QNGHYEHNSK NSSGLVTVIT EQELESINDD1020
 1021 LEDSSSSNTT NTTTTTTTTA TTEKTCVELQ K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..598] PSI-BLAST 38.0 Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin
    2 View Details [599..648] PSI-BLAST 61.0 Dystrophin
    3 View Details [649..748] PSI-BLAST 21.39794 No description for 2e5rA was found.
    4 View Details [749..953] PSI-BLAST 4.39794 No description for 2iw5A was found.
    5 View Details [954..1051] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.20953772435302 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • actin binding
    		•  1.12550770176867 bayes_pls_golite062009
  • chromatin binding
    		•  0.876241359231159 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.768149315604243 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.729872901177004 bayes_pls_golite062009
  • signal transducer activity
    		•  0.729872901177004 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
  • receptor activity
    		•  0.241046660106272 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.0831586119710046 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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