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View Structure Prediction Details

Protein: Dys-PE
Organism: Drosophila melanogaster
Length: 1051 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dys-PE.

Description E-value Query
Range		 Subject
Range
Dys-PD - The gene Dystrophin is referred to in FlyBase by the symbol Dmel\Dys (CG34157, FBgn0260003). It is a...
 615.0 [0..59] [1051..856]

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Predicted Domain #1
Region A:
Residues: [1-598] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLFASSGQA ATSPALAHSS SDEAGEVIEN SHTKRAGCSV LQSSGGKSRS LERYSGAPKI  60
   61 HQQTLEMLPP YATPTCSTRR RLLAPFRSLK RRSRSSSSSN ESHHFGNHLN NLVVVNVGAA 120
  121 AANGGVAKAK AKASSQSGDS GTGGTELEHE MEQDDDEEDE EEGEEMDELS LSYSQLSSSG 180
  181 CEEAEAPPED VPDDRQAAVE ATVSACVQHV ANERRRNILS LYSSSSEEQL HCRLGDITLV 240
  241 DDTYSNYDPQ NDAERMFLQV VGILRDENEK MRQFQKILED LSSRVALAEQ TKTSWLPPSS 300
  301 VGEANEQMQQ LQRLRDKMTT ASALLDDCNE QQSFFTANQV LVPTPCLSKL EDLNTRMKLL 360
  361 QIAMDERQKV LCQAGAQQTH ENGDDGRTTS NSGTIGPLPN LGQSVKPPWE RATTAANVPY 420
  421 YIDHERETTH WDHPEMIELM KGLADLNEIR FSAYRTAMKL RSVQKRLALD RISMSTACES 480
  481 FDRHGLRAQN DKLIDIPDMT TVLHSLYVTI DKIDLTLMLD LAINWILNVY DSQRTGQIRV 540
  541 LSFKVGLVLL CKGHLEEKYR YLFRLVADTD RRADQRRLGL LLHDCIQVPR QLGEVAAF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.0
Match: 1sjjA
Description: Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [599-648] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGSNIEPSVR SCLEQAGISQ EAIDGNQDIS IELQHFLGWL QHEPQSLVWL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.0
Match: 1eg3A
Description: Dystrophin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [649-748] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVLHRLAAAE AAKHQAKCNI CKEYPIVGFR YRCLKCFNFD MCQKCFFFGR NAKNHKLTHP  60
   61 MHEYCTTTTS TEDVRDFTRA LKNKFKSRKY FKKHPRVGYL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.39794
Match: 2e5rA
Description: No description for 2e5rA was found.

Predicted Domain #4
Region A:
Residues: [749-953] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVQSVLEGDA LESPAPSPQH TTHQLQNDMH SRLEMYASRL AQVEYGGTGS NSTPDSDDEH  60
   61 QLIAQYCQAL PGTSNGSAPK SPVQVMAAMD AEQREELEAI IRDLEEENAN LQAEYQQLCS 120
  121 KEQSGMPEDS NGMQHSSSSM TGLSGQGEQG QDMMAEAKLL RQHKGRLEAR MQILEDHNRQ 180
  181 LEAQLQRLRQ LLDEPNGGGS SATSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.39794
Match: 2iw5A
Description: No description for 2iw5A was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
actin binding 1.12550770176867 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
cytoskeletal protein binding 0.768149315604243 bayes_pls_golite062009
molecular transducer activity 0.729872901177004 bayes_pls_golite062009
signal transducer activity 0.729872901177004 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
receptor activity 0.241046660106272 bayes_pls_golite062009
transmembrane receptor activity 0.0831586119710046 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [954-1051] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLPSAPGSAL NSKPNTLQTR SVTASQLNTD SPAKMNQQNG HYEHNSKNSS GLVTVITEQE  60
   61 LESINDDLED SSSSNTTNTT TTTTTTATTE KTCVELQK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle