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Protein Overview: Dys-PD

General Information:
Name(s) found: Dys-PD / FBpp0110215 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • The gene Dystrophin is referred to in FlyBase by the symbol Dmel\Dys (CG34157, FBgn0260003). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15286810..15421117. It has the cytological map location 92A5-92A10. There is experimental evidence that it has the molecular function</span>: WW domain binding. There is experimental evidence that it is involved in the biological process</span>: neuromuscular synaptic transmission; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; regulation of short-term neuronal synaptic plasticity; muscle homeostasis; establishment of cell polarity. 39 alleles are reported. The phenotypes of these alleles are annotated with: posterior crossvein; presynaptic active zone; terminal button. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1854 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [ISS]
    dystrophin-associated glycoprotein complex [IPI][ISS][NAS]
    Biological Process: muscle organ development [ISS]
    muscle cell homeostasis [IMP]
    neuromuscular synaptic transmission [IDA]
    establishment of cell polarity [IMP]
    imaginal disc-derived wing vein morphogenesis [IMP]
    imaginal disc-derived wing vein specification [IMP]
    regulation of short-term neuronal synaptic plasticity [IDA]
    Molecular Function: zinc ion binding [IEA]
    structural constituent of muscle [ISS]
    actin binding [ISS]
    calcium ion binding [IEA]
    structural molecule activity [ISS]
    structural constituent of cytoskeleton [ISS]
    cytoskeletal protein binding [ISS]
    WW domain binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTTITAKIA QRQQQHQQHQ QQQLQHQQQQ QQQQQHQPTS SMNGFRITGY PAAATPPARS  60
   61 NPIYAKPNAH ELDLHISESL LYPGSTTQQQ QALQSSPGPP PQLTSMLPSS GLPGAAQPIA 120
  121 LKGNNPFLNS PSPTEAAPGV PTGLSSAQPA TSASSGNYEM PEYAEPSRLR GLKQRPHSIA 180
  181 VGGSPAQSSF VDYNAQQQQR LLQLSRQQQQ LRNAVTAAAS TANGGDKETL YAALFQQYRQ 240
  241 SPTNGQPAPP VPLHRKPAAA PVVPRRSQST PRPPLQQQQQ QQQAGINGQI NGNGNQRPRS 300
  301 LDRFNGGLQS EAPPIPLRRF PNGNGNNNNG TLSRQKSPKK SSSADNMLMS PAGSQVNTMR 360
  361 HSISFHGGQE TENGSKAEQT RPMSYAAPAP DQAYLEHQLR AYSEQLRTIT ESVRKYSEQA 420
  421 KLLSELKRQQ QLAKQSQTNL NLLTPTTCNN STGSNGNNNF QPNMISPEIV SKSLASLSTS 480
  481 QANEAQTPSN QLRLFLDNIR SSMRQEYQQH MPDDVLKPTS TLKRNGTDSL VTSNTAAKPE 540
  541 VEATPTPSDQ LRQFLDAIRA NKIPESVDKP KMTSSQTLDS FISKPLQMPD VTSGTPGGGV 600
  601 VGGQAASGGV AVNGQTNGIP TRRRPKSSII PSSSNGKLEQ REHSLVTSES FHQISDNLRL 660
  661 MSEDLQALSP SKAIPSSASS NSLKSLAANG GSSLTTELRV ITSSPYSTSP KLQQMVMSKS 720
  721 NSSLGSVTTP SSATTTPSTA PMITDFNEIL DSFQAMADKY KSKGSYDYLR KCSEALRQHS 780
  781 LQLKLQQQHQ AHQQQQLPAH QQQQHQQQQQ QQIQNGFASD DNSSSCSTTP GSIREAVQNL 840
  841 LLQPRNGFQI LDDRMRLFID IIDSQDRLSQ DLQSEIETHR VVYDRLDGTG RKLLGSLTSQ 900
  901 EDAVMLQRRL DEMNQRWNNL KSKSIAIRNR LESNSEHWNA LLLSLRELTE WVIRKDTELS 960
  961 TLGLGPVRGD AVSLQKQLDD HKAFRRQLED KRPIVESNLT SGRQYIANEA AVSDTSDTEA1020
 1021 NHDSDSRYMS AEEQSRELTR SIRREVGKLS EQWNNLIDRS DNWKHRLDEY MTKMRQFQKI1080
 1081 LEDLSSRVAL AEQTKTSWLP PSSVGEANEQ MQQLQRLRDK MTTASALLDD CNEQQSFFTA1140
 1141 NQVLVPTPCL SKLEDLNTRM KLLQIAMDER QKVLCQAGAQ QTHENGDDGR TTSNSGTIGP1200
 1201 LPNLGQSVKP PWERATTAAN VPYYIDHERE TTHWDHPEMI ELMKGLADLN EIRFSAYRTA1260
 1261 MKLRSVQKRL ALDRISMSTA CESFDRHGLR AQNDKLIDIP DMTTVLHSLY VTIDKIDLTL1320
 1321 MLDLAINWIL NVYDSQRTGQ IRVLSFKVGL VLLCKGHLEE KYRYLFRLVA DTDRRADQRR1380
 1381 LGLLLHDCIQ VPRQLGEVAA FGGSNIEPSV RSCLEQAGIS QEAIDGNQDI SIELQHFLGW1440
 1441 LQHEPQSLVW LPVLHRLAAA EAAKHQAKCN ICKEYPIVGF RYRCLKCFNF DMCQKCFFFG1500
 1501 RNAKNHKLTH PMHEYCTTTT STEDVRDFTR ALKNKFKSRK YFKKHPRVGY LPVQSVLEGD1560
 1561 ALESPAPSPQ HTTHQLQNDM HSRLEMYASR LAQVEYGGTG SNSTPDSDDE HQLIAQYCQA1620
 1621 LPGTSNGSAP KSPVQVMAAM DAEQREELEA IIRDLEEENA NLQAEYQQLC SKEQSGMPED1680
 1681 SNGMQHSSSS MTGLSGQGEQ GQDMMAEAKL LRQHKGRLEA RMQILEDHNR QLEAQLQRLR1740
 1741 QLLDEPNGGG SSATSSGLPS APGSALNSKP NTLQTRSVTA SQLNTDSPAK MNQQNGHYEH1800
 1801 NSKNSSGLVT VITEQELESI NDDLEDSSSS NTTNTTTTTT TTATTEKTCV ELQK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] MSA 2.186994 View MSA. No confident structure predictions are available.
    2 View Details [184..250] deduced N/A No confident structure predictions are available.
    3 View Details [251..338] deduced N/A No confident structure predictions are available.
    4 View Details [339..485] deduced N/A No confident structure predictions are available.
    5 View Details [486..896] PSI-BLAST 14.69897 Heavy meromyosin subfragment
    6 View Details [897..1184] FFAS03 2.83 Crystal Structure of Repeats 15, 16 and 17 of Chicken Brain Alpha Spectrin
    7 View Details [1185..1449] PSI-BLAST 57.522879 Dystrophin
    8 View Details [1450..1559] PSI-BLAST 25.522879 No description for 2e5rA was found.
    9 View Details [1560..1621] deduced N/A No confident structure predictions are available.
    10 View Details [1622..1749] FFAS03 2.02 No description for 2fxmA was found.
    11 View Details [1750..1854] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • structural constituent of muscle
    		•  5.54109779906915 bayes_pls_golite062009
  • acetylcholine transmembrane transporter activity
    		•  4.63361193364389 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.2682543222543 bayes_pls_golite062009
  • binding
    		•  2.62219069341981 bayes_pls_golite062009
  • transcription activator activity
    		•  2.28375305944516 bayes_pls_golite062009
  • transcription factor binding
    		•  2.18630749239417 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.11906774871731 bayes_pls_golite062009
  • metal ion binding
    		•  2.11094352721028 bayes_pls_golite062009
  • cation binding
    		•  2.11094352721028 bayes_pls_golite062009
  • ion binding
    		•  2.10331783734535 bayes_pls_golite062009
  • transcription cofactor activity
    		•  2.07432061489599 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.02433252968502 bayes_pls_golite062009
  • actin binding
    		•  2.02356543483094 bayes_pls_golite062009
  • DNA binding
    		•  1.73924929536227 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.53225451586959 bayes_pls_golite062009
  • protein binding
    		•  1.46903005775608 bayes_pls_golite062009
  • calcium ion binding
    		•  1.40919295397643 bayes_pls_golite062009
  • myosin binding
    		•  1.23881879879813 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • motor activity
    		•  1.08123526270094 bayes_pls_golite062009
  • nitric-oxide synthase binding
    		•  0.965098383344279 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.933783050059916 bayes_pls_golite062009
  • signal transducer activity
    		•  0.933783050059916 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.867600046278719 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.717054504236607 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • structural molecule activity
    		•  0.640474644163009 bayes_pls_golite062009
  • actin filament binding
    		•  0.512173584028638 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.45412801027969 bayes_pls_golite062009
  • myosin II heavy chain binding
    		•  0.308481284245779 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • catalytic activity
    		•  0.210712504691113 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.205877568518 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.193201281459889 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.18603158355229 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.15875878144391 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0305250212662123 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.
    11 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle