| Protein: | Dys-PD |
| Organism: | Drosophila melanogaster |
| Length: | 1854 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dys-PD.
| Description | E-value | Query Range |
Subject Range |
|
|
876.0 | [0..1] | [1854..1] |
|
Region A: Residues: [1-183] |
1 11 21 31 41 51
| | | | | |
1 MTTTITAKIA QRQQQHQQHQ QQQLQHQQQQ QQQQQHQPTS SMNGFRITGY PAAATPPARS 60
61 NPIYAKPNAH ELDLHISESL LYPGSTTQQQ QALQSSPGPP PQLTSMLPSS GLPGAAQPIA 120
121 LKGNNPFLNS PSPTEAAPGV PTGLSSAQPA TSASSGNYEM PEYAEPSRLR GLKQRPHSIA 180
181 VGG
|
| Detection Method: |  |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [184-250] |
1 11 21 31 41 51
| | | | | |
1 SPAQSSFVDY NAQQQQRLLQ LSRQQQQLRN AVTAAASTAN GGDKETLYAA LFQQYRQSPT 60
61 NGQPAPP
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [251-338] |
1 11 21 31 41 51
| | | | | |
1 VPLHRKPAAA PVVPRRSQST PRPPLQQQQQ QQQAGINGQI NGNGNQRPRS LDRFNGGLQS 60
61 EAPPIPLRRF PNGNGNNNNG TLSRQKSP
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [339-485] |
1 11 21 31 41 51
| | | | | |
1 KKSSSADNML MSPAGSQVNT MRHSISFHGG QETENGSKAE QTRPMSYAAP APDQAYLEHQ 60
61 LRAYSEQLRT ITESVRKYSE QAKLLSELKR QQQLAKQSQT NLNLLTPTTC NNSTGSNGNN 120
121 NFQPNMISPE IVSKSLASLS TSQANEA
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [486-896] |
1 11 21 31 41 51
| | | | | |
1 QTPSNQLRLF LDNIRSSMRQ EYQQHMPDDV LKPTSTLKRN GTDSLVTSNT AAKPEVEATP 60
61 TPSDQLRQFL DAIRANKIPE SVDKPKMTSS QTLDSFISKP LQMPDVTSGT PGGGVVGGQA 120
121 ASGGVAVNGQ TNGIPTRRRP KSSIIPSSSN GKLEQREHSL VTSESFHQIS DNLRLMSEDL 180
181 QALSPSKAIP SSASSNSLKS LAANGGSSLT TELRVITSSP YSTSPKLQQM VMSKSNSSLG 240
241 SVTTPSSATT TPSTAPMITD FNEILDSFQA MADKYKSKGS YDYLRKCSEA LRQHSLQLKL 300
301 QQQHQAHQQQ QLPAHQQQQH QQQQQQQIQN GFASDDNSSS CSTTPGSIRE AVQNLLLQPR 360
361 NGFQILDDRM RLFIDIIDSQ DRLSQDLQSE IETHRVVYDR LDGTGRKLLG S
|
| Detection Method: | |
| Confidence: | 14.69897 |
| Match: | 1i84S |
| Description: | Heavy meromyosin subfragment |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [897-1184] |
1 11 21 31 41 51
| | | | | |
1 LTSQEDAVML QRRLDEMNQR WNNLKSKSIA IRNRLESNSE HWNALLLSLR ELTEWVIRKD 60
61 TELSTLGLGP VRGDAVSLQK QLDDHKAFRR QLEDKRPIVE SNLTSGRQYI ANEAAVSDTS 120
121 DTEANHDSDS RYMSAEEQSR ELTRSIRREV GKLSEQWNNL IDRSDNWKHR LDEYMTKMRQ 180
181 FQKILEDLSS RVALAEQTKT SWLPPSSVGE ANEQMQQLQR LRDKMTTASA LLDDCNEQQS 240
241 FFTANQVLVP TPCLSKLEDL NTRMKLLQIA MDERQKVLCQ AGAQQTHE
|
| Detection Method: | |
| Confidence: | 2.83 |
| Match: | 1u4qA |
| Description: | Crystal Structure of Repeats 15, 16 and 17 of Chicken Brain Alpha Spectrin |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [1185-1449] |
1 11 21 31 41 51
| | | | | |
1 NGDDGRTTSN SGTIGPLPNL GQSVKPPWER ATTAANVPYY IDHERETTHW DHPEMIELMK 60
61 GLADLNEIRF SAYRTAMKLR SVQKRLALDR ISMSTACESF DRHGLRAQND KLIDIPDMTT 120
121 VLHSLYVTID KIDLTLMLDL AINWILNVYD SQRTGQIRVL SFKVGLVLLC KGHLEEKYRY 180
181 LFRLVADTDR RADQRRLGLL LHDCIQVPRQ LGEVAAFGGS NIEPSVRSCL EQAGISQEAI 240
241 DGNQDISIEL QHFLGWLQHE PQSLV
|
| Detection Method: | |
| Confidence: | 57.522879 |
| Match: | 1eg3A |
| Description: | Dystrophin |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| structural constituent of muscle | 5.54109779906915 | bayes_pls_golite062009 |
| acetylcholine transmembrane transporter activity | 4.63361193364389 | bayes_pls_golite062009 |
| transcription regulator activity | 3.2682543222543 | bayes_pls_golite062009 |
| binding | 2.62219069341981 | bayes_pls_golite062009 |
| transcription activator activity | 2.28375305944516 | bayes_pls_golite062009 |
| transcription factor binding | 2.18630749239417 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 2.11906774871731 | bayes_pls_golite062009 |
| metal ion binding | 2.11094352721028 | bayes_pls_golite062009 |
| cation binding | 2.11094352721028 | bayes_pls_golite062009 |
| ion binding | 2.10331783734535 | bayes_pls_golite062009 |
| transcription cofactor activity | 2.07432061489599 | bayes_pls_golite062009 |
| transcription coactivator activity | 2.02433252968502 | bayes_pls_golite062009 |
| actin binding | 2.02356543483094 | bayes_pls_golite062009 |
| DNA binding | 1.73924929536227 | bayes_pls_golite062009 |
| nucleic acid binding | 1.53225451586959 | bayes_pls_golite062009 |
| protein binding | 1.46903005775608 | bayes_pls_golite062009 |
| calcium ion binding | 1.40919295397643 | bayes_pls_golite062009 |
| myosin binding | 1.23881879879813 | bayes_pls_golite062009 |
| transporter activity | 1.15928534291452 | bayes_pls_golite062009 |
| motor activity | 1.08123526270094 | bayes_pls_golite062009 |
| nitric-oxide synthase binding | 0.965098383344279 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.945691505472547 | bayes_pls_golite062009 |
| molecular transducer activity | 0.933783050059916 | bayes_pls_golite062009 |
| signal transducer activity | 0.933783050059916 | bayes_pls_golite062009 |
| microfilament motor activity | 0.867600046278719 | bayes_pls_golite062009 |
| amine transmembrane transporter activity | 0.717054504236607 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.693724160233023 | bayes_pls_golite062009 |
| structural molecule activity | 0.640474644163009 | bayes_pls_golite062009 |
| actin filament binding | 0.512173584028638 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.45412801027969 | bayes_pls_golite062009 |
| myosin II heavy chain binding | 0.308481284245779 | bayes_pls_golite062009 |
| active transmembrane transporter activity | 0.246383459363256 | bayes_pls_golite062009 |
| catalytic activity | 0.210712504691113 | bayes_pls_golite062009 |
| actin-dependent ATPase activity | 0.205877568518 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.193201281459889 | bayes_pls_golite062009 |
| transcription repressor activity | 0.18603158355229 | bayes_pls_golite062009 |
| myosin heavy chain binding | 0.15875878144391 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 0.0305250212662123 | bayes_pls_golite062009 |
|
Region A: Residues: [1450-1559] |
1 11 21 31 41 51
| | | | | |
1 WLPVLHRLAA AEAAKHQAKC NICKEYPIVG FRYRCLKCFN FDMCQKCFFF GRNAKNHKLT 60
61 HPMHEYCTTT TSTEDVRDFT RALKNKFKSR KYFKKHPRVG YLPVQSVLEG
|
| Detection Method: | |
| Confidence: | 25.522879 |
| Match: | 2e5rA |
| Description: | No description for 2e5rA was found. |
|
Region A: Residues: [1560-1621] |
1 11 21 31 41 51
| | | | | |
1 DALESPAPSP QHTTHQLQND MHSRLEMYAS RLAQVEYGGT GSNSTPDSDD EHQLIAQYCQ 60
61 AL
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1622-1749] |
1 11 21 31 41 51
| | | | | |
1 PGTSNGSAPK SPVQVMAAMD AEQREELEAI IRDLEEENAN LQAEYQQLCS KEQSGMPEDS 60
61 NGMQHSSSSM TGLSGQGEQG QDMMAEAKLL RQHKGRLEAR MQILEDHNRQ LEAQLQRLRQ 120
121 LLDEPNGG
|
| Detection Method: | |
| Confidence: | 2.02 |
| Match: | 2fxmA |
| Description: | No description for 2fxmA was found. |
|
Region A: Residues: [1750-1854] |
1 11 21 31 41 51
| | | | | |
1 GSSATSSGLP SAPGSALNSK PNTLQTRSVT ASQLNTDSPA KMNQQNGHYE HNSKNSSGLV 60
61 TVITEQELES INDDLEDSSS SNTTNTTTTT TTTATTEKTC VELQK
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
