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Protein Overview: RAD53_YEAST

General Information:
Name(s) found: RAD53_YEAST [Swiss-Prot]
Description(s) found:
  • Serine/threonine-protein kinase RAD53 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAD53 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 821 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENITQPTQQ STQATQRFLI EKFSQEQIGE NIVCRVICTT GQIPIRDLSA DISQVLKEKR  60
   61 SIKKVWTFGR NPACDYHLGN ISRLSNKHFQ ILLGEDGNLL LNDISTNGTW LNGQKVEKNS 120
  121 NQLLSQGDEI TVGVGVESDI LSLVIFINDK FKQCLEQNKV DRIRSNLKNT SKIASPGLTS 180
  181 STASSMVANK TGIFKDFSII DEVVGQGAFA TVKKAIERTT GKTFAVKIIS KRKVIGNMDG 240
  241 VTRELEVLQK LNHPRIVRLK GFYEDTESYY MVMEFVSGGD LMDFVAAHGA VGEDAGREIS 300
  301 RQILTAIKYI HSMGISHRDL KPDNILIEQD DPVLVKITDF GLAKVQGNGS FMKTFCGTLA 360
  361 YVAPEVIRGK DTSVSPDEYE ERNEYSSLVD MWSMGCLVYV ILTGHLPFSG STQDQLYKQI 420
  421 GRGSYHEGPL KDFRISEEAR DFIDSLLQVD PNNRSTAAKA LNHPWIKMSP LGSQSYGDFS 480
  481 QISLSQSLSQ QKLLENMDDA QYEFVKAQRK LQMEQQLQEQ DQEDQDGKIQ GFKIPAHAPI 540
  541 RYTQPKSIEA ETREQKLLHS NNTENVKSSK KKGNGRFLTL KPLPDSIIQE SLEIQQGVNP 600
  601 FFIGRSEDCN CKIEDNRLSR VHCFIFKKRH AVGKSMYESP AQGLDDIWYC HTGTNVSYLN 660
  661 NNRMIQGTKF LLQDGDEIKI IWDKNNKFVI GFKVEINDTT GLFNEGLGML QEQRVVLKQT 720
  721 AEEKDLVKKL TQMMAAQRAN QPSASSSSMS AKKPPVSDTN NNGNNSVLND LVESPINANT 780
  781 GNILKRIHSV SLSQSQIDPS KKVKRAKLDQ TSKGPENLQF S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] PSI-BLAST 904.325697 Phosphotyrosine binding domain of Rad53
    2 View Details [166..278]
    [491..534]    		 PSI-BLAST 622.457575 Calmodulin-dependent protein kinase
    3 View Details [279..490] PSI-BLAST 622.457575 Calmodulin-dependent protein kinase
    4 View Details [535..753] PSI-BLAST 1080.0 Phosphotyrosine binding domain of Rad53
    5 View Details [754..821] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.23926962992034 bayes_pls_golite062009
  • DNA binding
    		•  3.12131448113144 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.91028042727128 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  2.82706319058551 bayes_pls_golite062009
  • histone binding
    		•  2.79033314021304 bayes_pls_golite062009
  • protein binding
    		•  2.39508335485646 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.25132862320271 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  2.10556565012417 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.95921851331594 bayes_pls_golite062009
  • transcription factor activity
    		•  1.89464382469326 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.88096476099716 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.84746485315093 bayes_pls_golite062009
  • kinase activity
    		•  1.82476774968305 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.78280248668052 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.78246425241581 bayes_pls_golite062009
  • protein kinase activity
    		•  1.73373132141588 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.66058356077795 bayes_pls_golite062009
  • SMAD binding
    		•  1.6101563888469 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.60737837207077 bayes_pls_golite062009
  • transcription activator activity
    		•  1.53960544319629 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.48483625404671 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  1.44498281734982 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  1.3333129315031 bayes_pls_golite062009
  • transferase activity
    		•  1.29860325699399 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.1868962075754 bayes_pls_golite062009
  • promoter binding
    		•  1.15188009117562 bayes_pls_golite062009
  • transcription factor binding
    		•  0.93544177518754 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.9108432673413 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.90981150861416 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • signal transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • R-SMAD binding
    		•  0.70816286022176 bayes_pls_golite062009
  • chromatin binding
    		•  0.62935034847038 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.447699674047884 bayes_pls_golite062009
  • co-SMAD binding
    		•  0.325865547214071 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.279328480488455 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.270284689687439 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0595316953833198 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0504553861724597 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.23926962992034 bayes_pls_golite062009
  • DNA binding
    		•  3.12131448113144 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.91028042727128 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  2.82706319058551 bayes_pls_golite062009
  • histone binding
    		•  2.79033314021304 bayes_pls_golite062009
  • protein binding
    		•  2.39508335485646 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.25132862320271 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  2.10556565012417 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.95921851331594 bayes_pls_golite062009
  • transcription factor activity
    		•  1.89464382469326 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.88096476099716 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.84746485315093 bayes_pls_golite062009
  • kinase activity
    		•  1.82476774968305 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.78280248668052 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.78246425241581 bayes_pls_golite062009
  • protein kinase activity
    		•  1.73373132141588 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.66058356077795 bayes_pls_golite062009
  • SMAD binding
    		•  1.6101563888469 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.60737837207077 bayes_pls_golite062009
  • transcription activator activity
    		•  1.53960544319629 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.48483625404671 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  1.44498281734982 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  1.3333129315031 bayes_pls_golite062009
  • transferase activity
    		•  1.29860325699399 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.1868962075754 bayes_pls_golite062009
  • promoter binding
    		•  1.15188009117562 bayes_pls_golite062009
  • transcription factor binding
    		•  0.93544177518754 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.9108432673413 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.90981150861416 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • signal transducer activity
    		•  0.767071864136971 bayes_pls_golite062009
  • R-SMAD binding
    		•  0.70816286022176 bayes_pls_golite062009
  • chromatin binding
    		•  0.62935034847038 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.447699674047884 bayes_pls_golite062009
  • co-SMAD binding
    		•  0.325865547214071 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.279328480488455 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  0.270284689687439 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0595316953833198 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0504553861724597 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle