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Protein Overview: IMB1_YEAST

General Information:
Name(s) found: IMB1_YEAST [Swiss-Prot]
Description(s) found:
  • Importin subunit beta-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KAP95 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 861 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTAEFAQLL ENSILSPDQN IRLTSETQLK KLSNDNFLQF AGLSSQVLID ENTKLEGRIL  60
   61 AALTLKNELV SKDSVKTQQF AQRWITQVSP EAKNQIKTNA LTALVSIEPR IANAAAQLIA 120
  121 AIADIELPHG AWPELMKIMV DNTGAEQPEN VKRASLLALG YMCESADPQS QALVSSSNNI 180
  181 LIAIVQGAQS TETSKAVRLA ALNALADSLI FIKNNMEREG ERNYLMQVVC EATQAEDIEV 240
  241 QAAAFGCLCK IMSLYYTFMK PYMEQALYAL TIATMKSPND KVASMTVEFW STICEEEIDI 300
  301 AYELAQFPQS PLQSYNFALS SIKDVVPNLL NLLTRQNEDP EDDDWNVSMS AGACLQLFAQ 360
  361 NCGNHILEPV LEFVEQNITA DNWRNREAAV MAFGSIMDGP DKVQRTYYVH QALPSILNLM 420
  421 NDQSLQVKET TAWCIGRIAD SVAESIDPQQ HLPGVVQACL IGLQDHPKVA TNCSWTIINL 480
  481 VEQLAEATPS PIYNFYPALV DGLIGAANRI DNEFNARASA FSALTTMVEY ATDTVAETSA 540
  541 SISTFVMDKL GQTMSVDENQ LTLEDAQSLQ ELQSNILTVL AAVIRKSPSS VEPVADMLMG 600
  601 LFFRLLEKKD SAFIEDDVFY AISALAASLG KGFEKYLETF SPYLLKALNQ VDSPVSITAV 660
  661 GFIADISNSL EEDFRRYSDA MMNVLAQMIS NPNARRELKP AVLSVFGDIA SNIGADFIPY 720
  721 LNDIMALCVA AQNTKPENGT LEALDYQIKV LEAVLDAYVG IVAGLHDKPE ALFPYVGTIF 780
  781 QFIAQVAEDP QLYSEDATSR AAVGLIGDIA AMFPDGSIKQ FYGQDWVIDY IKRTRSGQLF 840
  841 SQATKDTARW AREQQKRQLS L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..248] PSI-BLAST 1397.0 Importin beta
    2 View Details [249..442] PSI-BLAST 1397.0 Importin beta
    3 View Details [443..541] PSI-BLAST 1397.0 Importin beta
    4 View Details [542..648] PSI-BLAST 1397.0 Importin beta
    5 View Details [649..861] PSI-BLAST 1397.0 Importin beta

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  4.58709163830613 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  2.74547353635661 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.34284977509828 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • nuclear export signal receptor activity
    		•  2.13470398426489 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  1.91487015967262 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.76231475025891 bayes_pls_golite062009
  • protein binding
    		•  1.73688475473996 bayes_pls_golite062009
  • DNA binding
    		•  1.62032607987786 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.09652988954158 bayes_pls_golite062009
  • transcription factor activity
    		•  0.923253759652909 bayes_pls_golite062009
  • structural molecule activity
    		•  0.908029258648777 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.83079633551839 bayes_pls_golite062009
  • translation regulator activity
    		•  0.82193201542158 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.803700928110921 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.773975545005505 bayes_pls_golite062009
  • signal transducer activity
    		•  0.662662274021266 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.662662274021266 bayes_pls_golite062009
  • actin binding
    		•  0.572473732371314 bayes_pls_golite062009
  • signal sequence binding
    		•  0.57106697498903 bayes_pls_golite062009
  • mRNA binding
    		•  0.46864854653143 bayes_pls_golite062009
  • RNA binding
    		•  0.40024158562931 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.248585912061178 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0405268469927988 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0232727461674547 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle