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Protein Overview: EG10202

General Information:
Name(s) found: dacB / EG10202 [EcoGene]
Description(s) found:
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  • D-alanyl-D-alanine carboxypeptidase / D-alanine D-alanine carboxypeptidase PBP4; penicillin-binding protein 4 [EcoGene]
  • D-alanyl-D-alanine carboxypeptidase [Escherichia coli K12] [nr-271106-contam.fasta]
  • D-alanyl-D-alanine carboxypeptidase, fraction B [Escherichia coli] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • D-alanyl-D-alanine carboxypeptidase [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 477 amino acids

    Gene Ontology:
    Cellular Component: outer membrane-bounded periplasmic space [IMPLink to PubMed article]
    Biological Process: regulation of cell shape [IEA][IGILink to PubMed articleLink to PubMed articleLink to PubMed article]
    cellular cell wall macromolecule metabolic process [IDALink to PubMed article]
    cell wall macromolecule catabolic process [IDALink to PubMed article]
    peptidoglycan turnover [IDALink to PubMed article]
    peptidoglycan catabolic process [IDALink to PubMed article]
    peptidoglycan biosynthetic process [IEA]
    response to antibiotic [IEA]
    cellular cell wall organization [IDALink to PubMed article][IMPLink to PubMed article]
    cytokinesis [IGILink to PubMed article]
    cell cycle [IEA]
    binary fission [IGILink to PubMed article]
    peptidoglycan metabolic process [IDALink to PubMed article][IMPLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    proteolysis [IEA]
    Molecular Function: carboxypeptidase activity [IMPLink to PubMed articleLink to PubMed article]
    protein binding [IPILink to PubMed article]
    serine-type D-Ala-D-Ala carboxypeptidase activity [IEA][IMPLink to PubMed article]
    endopeptidase activity [IDALink to PubMed article]
    penicillin binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFSRFIIGL TSCIAFSVQA ANVDEYITQL PAGANLALMV QKVGASAPAI DYHSQQMALP  60
   61 ASTQKVITAL AALIQLGPDF RFTTTLETKG NVENGVLKGD LVARFGADPT LKRQDIRNMV 120
  121 ATLKKSGVNQ IDGNVLIDTS IFASHDKAPG WPWNDMTQCF SAPPAAAIVD RNCFSVSLYS 180
  181 APKPGDMAFI RVASYYPVTM FSQVRTLPRG SAEAQYCELD VVPGDLNRFT LTGCLPQRSE 240
  241 PLPLAFAVQD GASYAGAILK DELKQAGITW SGTLLRQTQV NEPGTVVASK QSAPLHDLLK 300
  301 IMLKKSDNMI ADTVFRMIGH ARFNVPGTWR AGSDAVRQIL RQQAGVDIGN TIIADGSGLS 360
  361 RHNLIAPATM MQVLQYIAQH DNELNFISML PLAGYDGSLQ YRAGLHQAGV DGKVSAKTGS 420
  421 LQGVYNLAGF ITTASGQRMA FVQYLSGYAV EPADQRNRRI PLVRFESRLY KDIYQNN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..477] PSI-BLAST 88.522879 No description for 2ex2A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  3.49880252911035 bayes_pls_golite062009
  • serine-type D-Ala-D-Ala carboxypeptidase activity
    		•  3.12650314537616 bayes_pls_golite062009
  • penicillin binding
    		•  2.89507018520983 bayes_pls_golite062009
  • serine-type carboxypeptidase activity
    		•  2.70174066798582 bayes_pls_golite062009
  • serine-type exopeptidase activity
    		•  2.69091897402517 bayes_pls_golite062009
  • drug binding
    		•  2.27792716125407 bayes_pls_golite062009
  • peptidase activity
    		•  2.02492099567377 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  1.96547160092829 bayes_pls_golite062009
  • catalytic activity
    		•  1.85492008367309 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.82206884632324 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  1.13698125224034 bayes_pls_golite062009
  • binding
    		•  1.11566650386305 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.402878339821269 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.392678049813626 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.150639262435765 bayes_pls_golite062009
  • protein binding
    		•  0.0666688846338231 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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