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Protein Overview: EG10533

General Information:
Name(s) found: lexA / EG10533 [EcoGene]
Description(s) found:
Found 6 descriptions.
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  • transcriptional repressor of SOS regulon / Global regulator (repressor) for SOS regulon; dimeric [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 202 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: DNA repair [IEA]
    negative regulation of transcription, DNA-dependent [IEA]
    transcription [IDALink to PubMed articleLink to PubMed article][IEA][IMPLink to PubMed article]
    DNA replication [IEA]
    proteolysis [IEA]
    SOS response [IEA]
    regulation of transcription [IEA]
    response to DNA damage stimulus [IEA]
    Molecular Function: DNA binding [IDALink to PubMed article][IEA]
    protein binding [IPILink to PubMed article]
    serine-type endopeptidase activity [IEA]
    transcription repressor activity [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKALTARQQE VFDLIRDHIS QTGMPPTRAE IAQRLGFRSP NAAEEHLKAL ARKGVIEIVS  60
   61 GASRGIRLLQ EEEEGLPLVG RVAAGEPLLA QQHIEGHYQV DPSLFKPNAD FLLRVSGMSM 120
  121 KDIGIMDGDL LAVHKTQDVR NGQVVVARID DEVTVKRLKK QGNKVELLPE NSEFKPIVVD 180
  181 LRQQSFTIEG LAVGVIRNGD WL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..202] PSI-BLAST 53.30103 LexA repressor, N-terminal DNA-binding domain; LexA C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  1.30784351115827 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.603302373860066 bayes_pls_golite062009
  • transcription activator activity
    		•  0.53294679084865 bayes_pls_golite062009
  • DNA binding
    		•  0.452668330421957 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.44420590157367 bayes_pls_golite062009
  • catalytic activity
    		•  0.415601732277814 bayes_pls_golite062009
  • binding
    		•  0.355412070907203 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0554645717043947 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle