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Protein Overview: FEN1_PLAF7

General Information:
Name(s) found: FEN1_PLAF7 [Swiss-Prot]
Description(s) found:
Found 8 descriptions.
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  • Flap endonuclease 1 OS=Plasmodium falciparum (isolate 3D7) GN=FEN1 PE=3 SV=1 [Swiss-Prot]
    • Organism: Plasmodium falciparum 3D7
    Length: 672 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIKGLTKFI ADAAPNAIKE IKIESLMGRI IAIDASMSLY QFIIAIRDSE QYGNLTNESG  60
   61 ETTSHISGLM SRSIRLMENG LKPIYVFDGA PPELKGSELE KRGEKRQKAE ELLKKAKEEG 120
  121 NLEEIKKQSG RTVRVTRKQN EEAKKLLTLM GIPIIEAPCE AESQCAFLTK YNLAHATATE 180
  181 DADALVFGTK ILIRNLNANA TSNQNKNKNN SKRGYILTEI NLEQVLKGLN LTMDEFIDFC 240
  241 ILCGCDYCDT IKGIGSKTAY NLIKEYNCIE KIIENIDQNK YQVPSNFRFQ EARKSFINPN 300
  301 VLPKEDIKID WNEPQIEELK HFLIKDYNFN ELRVTNYINR LLKARKVTTQ RRLDNFFTAC 360
  361 TKKSTKLIVE ETKKEQTLPA RKGKKRPTAG DKNKQKAVKR KIEQANANGH HKMKEENKSV 420
  421 DNEKNEDGIK SVDNEKNEDG IKSVDDEKNL DDEKNLDDEK NKDDEKNKDD EKNKDDEKNK 480
  481 DDEKNKDDEK KSLDNFSSNL FDSDKESESG NIIKNEKQNM DDEKINDNLP SLFGDHSRIR 540
  541 HTENKDNISD INNNNNNNNS SSNNNNISNN HFNSVSSNST FNSSTKLKSE DTLKSNSPLK 600
  601 EDSPNSYNNI KNNNHTININ SQINNHKEPI SNNNLNNINN STEIKKKNTL FLLPFCPKDV 660
  661 TNVKKKKYTQ RC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..376] PSI-BLAST 107.0 Crystal structure of the human FEN1-PCNA complex
    2 View Details [377..486] deduced N/A No confident structure predictions are available.
    3 View Details [487..672] MSA 1.376995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity, acting on ester bonds
    		•  5.44893156272125 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  4.17543266498933 bayes_pls_golite062009
  • DNA polymerase activity
    		•  4.1412804577877 bayes_pls_golite062009
  • flap endonuclease activity
    		•  4.10438637013244 bayes_pls_golite062009
  • exonuclease activity
    		•  3.99717729574528 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  3.90367500308359 bayes_pls_golite062009
  • endonuclease activity
    		•  3.40075034200919 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  3.29138075959109 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  3.25110450559975 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  3.19536858640519 bayes_pls_golite062009
  • nuclease activity
    		•  2.9643999717473 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  2.76402807313057 bayes_pls_golite062009
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  2.49388502336873 bayes_pls_golite062009
  • hydrolase activity
    		•  2.4418166499042 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.33034300966639 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  2.26658239783943 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.10834170214137 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  2.09057967200253 bayes_pls_golite062009
  • binding
    		•  2.06833406478856 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.02510018436829 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  2.0005433655378 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.9833086883205 bayes_pls_golite062009
  • DNA binding
    		•  1.93844174573408 bayes_pls_golite062009
  • 5'-flap endonuclease activity
    		•  1.81850767854435 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.70042864382698 bayes_pls_golite062009
  • catalytic activity
    		•  1.37534898662234 bayes_pls_golite062009
  • ribonuclease H activity
    		•  1.29762010718359 bayes_pls_golite062009
  • single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
    		•  1.15948049342759 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.901965019685213 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.626785110524684 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.512509234493511 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.50487165366129 bayes_pls_golite062009
  • protein binding
    		•  0.488846604207788 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.351084053450465 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.319622686426271 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.312346277055223 bayes_pls_golite062009
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
    		•  0.14861832363159 bayes_pls_golite062009
  • 3'-5'-exodeoxyribonuclease activity
    		•  0.0205129272358 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle