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Protein Overview: WNK8_ARATH

General Information:
Name(s) found: WNK8_ARATH [Swiss-Prot]
Description(s) found:
Found 10 descriptions.
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  • Serine/threonine-protein kinase WNK8 OS=Arabidopsis thaliana GN=WNK8 PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 563 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: photoperiodism, flowering [IMP]
    protein amino acid autophosphorylation [IDA]
    vegetative to reproductive phase transition of meristem [IMP]
    protein amino acid phosphorylation [IDA][TAS]
    Molecular Function: protein kinase activity [IDA][TAS]
    kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASGSGFLGQ ISSMEEADFA EKDPSGRYIR YDDVLGRGAF KTVYKAFDEV DGIEVAWNLV  60
   61 SIEDVMQMPG QLERLYSEVH LLKALKHENI IKLFYSWVDE KNKTINMITE LFTSGSLRVY 120
  121 RKKHRKVDPK AIKNWARQIL KGLNYLHSQN PPVIHRDLKC DNIFVNGNTG EVKIGDLGLA 180
  181 TVLQQPTARS VIGTPEFMAP ELYEEEYNEL VDIYSFGMCM LEMVTCEYPY NECRNQAQIY 240
  241 KKVTSNIKPQ SLGKVDDPQV RQFIEKCLLP ASSRPTALEL SKDPFLARDG GKDSALLASS 300
  301 STSSKYVRPP QLEHLPMDVD HNENKSVSSN EDYPWSQTIE LQRIAENKEF RLRGERSDDV 360
  361 TASMVLRIAD PSGKCRIVHF AFYLESDTAT AIAEEMVEEL HLTSQEVVVI ADMIDDFIMQ 420
  421 LLSDRTSSHH NQNSPRLTHE DHEAANQQTV NSKDEEAAGQ SMKSDISADY YFPYSANDGN 480
  481 AAMEAGRDAE SMSSYLDSCS MMSTIYNLSI SDNDYPEDLK TELNLIESQF NQSFQDLLKL 540
  541 KEDAIENAKR KWITKKQKAV NIS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..306] PSI-BLAST 59.522879 Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
    2 View Details [307..445] FFAS03 2.21 No description for 2v3sA was found.
    3 View Details [446..563] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.26024936404169 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle