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Protein Overview: gi|168270828, gi...

General Information:
Name(s) found: gi|190689515 [NCBI NR]
gi|168270828 [NCBI NR]
Description(s) found:
Found 2 descriptions.
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  • gi|190689515|gb|ACE86532.1| insulin receptor substrate 1 protein [synthetic construct] [NCBI NR]
  • gi|168270828|dbj|BAG10207.1| insulin receptor substrate 1 [synthetic construct] [NCBI NR]
    • Organism: synthetic construct
    Length: 1242 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASPPESDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP  60
   61 KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKGH 120
  121 HDGAAALGAG GGGGSCSGSS GLGEAGEDLS YGDVPPGPAF KEVWQVILKP KGLGQTKNLI 180
  181 GIYRLCLTSK TISFVKLNSE AAAVVLQLMN IRRCGHSENF FFIEVGRSAV TGPGEFWMQV 240
  241 DDSVVAQNMH ETILEAMRAM SDEFRPRSKS QSSSNCSNPI SVPLRRHHLN NPPPSQVGLT 300
  301 RRSRTESITA TSPASMVGGK PGSFRVRASS DGEGTMSRPA SVDGSPVSPS TNRTHAHRHR 360
  361 GSARLHPPLN HSRSIPMPAS RCSPSATSPV SLSSSSTSGH GSTSDCLFPR RSSASVSGSP 420
  421 SDGGFISSDE YGSSPCDFRS SFRSVTPDSL GHTPPARGEE ELSNYICMGG KGPSTLTAPN 480
  481 GHYILSRGGN GHRCTPGTGL GTSPALAGDE AASAADLDNR FRKRTHSAGT SPTITHQKTP 540
  541 SQSSVASIEE YTEMMPAYPP GGGSGGRLPG HRHSAFVPTR SYPEEGLEMH PLERRGGHHR 600
  601 PDSSTLHTDD GYMPMSPGVA PVPSGRKGSG DYMPMSPKSV SAPQQIINPI RRHPQRVDPN 660
  661 GYMMMSPSGG CSPDIGGGPS SSSSSSNAVP SGTSYGKLWT NGVGGHHSHV LPHPKPPVES 720
  721 SGGKLLPCTG DYMNMSPVGD SNTSSPSDCY YGPEDPQHKP VLSYYSLPRS FKHTQRPGEP 780
  781 EEGARHQHLR LSTSSGRLLY AATADDSSSS TSSDSLGGGY CGARLEPSLP HPHHQVLQPH 840
  841 LPRKVDTAAQ TNSRLARPTR LSLGDPKAST LPRAREQQQQ QQPLLHPPEP KSPGEYVNIE 900
  901 FGSDQSGYLS GPVAFHSSPS VRCPSQLQPA PREEETGTEE YMKMDLGPGR RAAWQESTGV 960
  961 EMGRLGPAPP GAASICRPTR AVPSSRGDYM TMQMSCPRQS YVDTSPAAPV SYADMRTGIA1020
 1021 AEEVSLPRAT MAAASSSSAA SASPTGPQGA AELAAHSSLL GGPQGPGGMS AFTRVNLSPN1080
 1081 RNQSAKVIRA DPQGCRRRHS SETFSSTPSA TRVGNTVPFG AGAAVGGGGG SSSSSEDVKR1140
 1141 HSSASFENVW LRPGELGGAP KEPAKLCGAA GGLENGLNYI DLDLVKDFKQ CPQECTPEPQ1200
 1201 PPPPPPPHQP LGSGESSSTR RSSEDLSAYA SISFQKQPED RQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..302] PSI-BLAST 86.69897 Insulin receptor substrate 1, IRS-1
    2 View Details [303..423] deduced N/A No confident structure predictions are available.
    3 View Details [424..560] deduced N/A No confident structure predictions are available.
    4 View Details [561..691] deduced N/A No confident structure predictions are available.
    5 View Details [692..819] MSA 2.189986 View MSA. No confident structure predictions are available.
    6 View Details [820..1075] deduced N/A No confident structure predictions are available.
    7 View Details [1076..1242] MSA 4.157986 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SH2 domain binding
    		•  4.2225235101534 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  3.3707139031954 bayes_pls_golite062009
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.87341016128079 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.57493599999135 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.00463050491756 bayes_pls_golite062009
  • signal transducer activity
    		•  2.00463050491756 bayes_pls_golite062009
  • receptor activity
    		•  1.74512124922291 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.71651136304109 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.70142823077711 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  1.56969272757764 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46386016357802 bayes_pls_golite062009
  • DNA binding
    		•  1.44750105267972 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase docking protein activity
    		•  1.22810011804986 bayes_pls_golite062009
  • enzyme binding
    		•  1.17212675145623 bayes_pls_golite062009
  • receptor binding
    		•  1.00859318603128 bayes_pls_golite062009
  • kinase binding
    		•  0.961706066143 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.90578029954417 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.807602879164189 bayes_pls_golite062009
  • kinase activity
    		•  0.799643593066962 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.79883446648737 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.68831063656953 bayes_pls_golite062009
  • protein kinase binding
    		•  0.67284191028382 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.667839463640959 bayes_pls_golite062009
  • protein kinase activity
    		•  0.565124275151513 bayes_pls_golite062009
  • protein complex binding
    		•  0.55916857709427 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.470521479239198 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.391864697086635 bayes_pls_golite062009
  • transferase activity
    		•  0.358511518477625 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.189879136353541 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.0735802149531289 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0611639610381174 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0524559849408587 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0498422520006935 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle