| Protein: | IRS1 |
| Organism: | Homo sapiens |
| Length: | 1242 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IRS1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1242] | [1..1243] |
|
|
0.0 | [11..1240] | [1..1229] |
|
|
0.0 | [1..1242] | [1..1241] |
|
|
0.0 | [1..1242] | [1..1251] |
|
|
0.0 | [1..1242] | [1..1252] |
|
|
0.0 | [1..1242] | [1..1240] |
|
|
0.0 | [1..1242] | [1..1237] |
|
|
0.0 | [1..1242] | [1..1235] |
|
|
0.0 | [1..1242] | [1..1231] |
|
Region A: Residues: [1-302] |
1 11 21 31 41 51
| | | | | |
1 MASPPESDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP 60
61 KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKGH 120
121 HDGAAALGAG GGGGSCSGSS GLGEAGEDLS YGDVPPGPAF KEVWQVILKP KGLGQTKNLI 180
181 GIYRLCLTSK TISFVKLNSE AAAVVLQLMN IRRCGHSENF FFIEVGRSAV TGPGEFWMQV 240
241 DDSVVAQNMH ETILEAMRAM SDEFRPRSKS QSSSNCSNPI SVPLRRHHLN NPPPSQVGLT 300
301 RR
|
| Detection Method: |  |
| Confidence: | 86.69897 |
| Match: | 1qqgA |
| Description: | Insulin receptor substrate 1, IRS-1 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| SH2 domain binding | 4.2225235101534 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 3.3707139031954 | bayes_pls_golite062009 |
| binding | 3.29080729281876 | bayes_pls_golite062009 |
| protein binding | 3.17213698546013 | bayes_pls_golite062009 |
| insulin receptor binding | 2.87341016128079 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.57493599999135 | bayes_pls_golite062009 |
| molecular transducer activity | 2.00463050491756 | bayes_pls_golite062009 |
| signal transducer activity | 2.00463050491756 | bayes_pls_golite062009 |
| receptor activity | 1.74512124922291 | bayes_pls_golite062009 |
| transmembrane receptor activity | 1.71651136304109 | bayes_pls_golite062009 |
| transcription regulator activity | 1.70142823077711 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase signaling protein activity | 1.56969272757764 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46386016357802 | bayes_pls_golite062009 |
| DNA binding | 1.44750105267972 | bayes_pls_golite062009 |
| transporter activity | 1.28986800087234 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase docking protein activity | 1.22810011804986 | bayes_pls_golite062009 |
| enzyme binding | 1.17212675145623 | bayes_pls_golite062009 |
| receptor binding | 1.00859318603128 | bayes_pls_golite062009 |
| kinase binding | 0.961706066143 | bayes_pls_golite062009 |
| protein domain specific binding | 0.90578029954417 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 0.807602879164189 | bayes_pls_golite062009 |
| kinase activity | 0.799643593066962 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.79883446648737 | bayes_pls_golite062009 |
| receptor signaling protein activity | 0.68831063656953 | bayes_pls_golite062009 |
| protein kinase binding | 0.67284191028382 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 0.667839463640959 | bayes_pls_golite062009 |
| protein kinase activity | 0.565124275151513 | bayes_pls_golite062009 |
| protein complex binding | 0.55916857709427 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 0.470521479239198 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.391864697086635 | bayes_pls_golite062009 |
| transferase activity | 0.358511518477625 | bayes_pls_golite062009 |
| GTPase regulator activity | 0.355387992614734 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 0.335498703113274 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.189879136353541 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.0735802149531289 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.0611639610381174 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.0524559849408587 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.0498422520006935 | bayes_pls_golite062009 |
|
Region A: Residues: [303-423] |
1 11 21 31 41 51
| | | | | |
1 SRTESITATS PASMVGGKPG SFRVRASSDG EGTMSRPASV DGSPVSPSTN RTHAHRHRGS 60
61 ARLHPPLNHS RSIPMPASRC SPSATSPVSL SSSSTSGHGS TSDCLFPRRS SASVSGSPSD 120
121 G
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [424-560] |
1 11 21 31 41 51
| | | | | |
1 GFISSDEYGS SPCDFRSSFR SVTPDSLGHT PPARGEEELS NYICMGGKGP STLTAPNGHY 60
61 ILSRGGNGHR CTPGTGLGTS PALAGDEAAS AADLDNRFRK RTHSAGTSPT ITHQKTPSQS 120
121 SVASIEEYTE MMPAYPP
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [561-691] |
1 11 21 31 41 51
| | | | | |
1 GGGSGGRLPG HRHSAFVPTR SYPEEGLEMH PLERRGGHHR PDSSTLHTDD GYMPMSPGVA 60
61 PVPSGRKGSG DYMPMSPKSV SAPQQIINPI RRHPQRVDPN GYMMMSPSGG CSPDIGGGPS 120
121 SSSSSSNAVP S
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [692-819] |
1 11 21 31 41 51
| | | | | |
1 GTSYGKLWTN GVGGHHSHVL PHPKPPVESS GGKLLPCTGD YMNMSPVGDS NTSSPSDCYY 60
61 GPEDPQHKPV LSYYSLPRSF KHTQRPGEPE EGARHQHLRL STSSGRLLYA ATADDSSSST 120
121 SSDSLGGG
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [820-1075] |
1 11 21 31 41 51
| | | | | |
1 YCGARLEPSL PHPHHQVLQP HLPRKVDTAA QTNSRLARPT RLSLGDPKAS TLPRAREQQQ 60
61 QQQPLLHPPE PKSPGEYVNI EFGSDQSGYL SGPVAFHSSP SVRCPSQLQP APREEETGTE 120
121 EYMKMDLGPG RRAAWQESTG VEMGRLGPAP PGAASICRPT RAVPSSRGDY MTMQMSCPRQ 180
181 SYVDTSPAAP VSYADMRTGI AAEEVSLPRA TMAAASSSSA ASASPTGPQG AAELAAHSSL 240
241 LGGPQGPGGM SAFTRV
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1076-1242] |
1 11 21 31 41 51
| | | | | |
1 NLSPNRNQSA KVIRADPQGC RRRHSSETFS STPSATRVGN TVPFGAGAAV GGGGGSSSSS 60
61 EDVKRHSSAS FENVWLRPGE LGGAPKEPAK LCGAAGGLEN GLNYIDLDLV KDFKQCPQEC 120
121 TPEPQPPPPP PPHQPLGSGE SSSTRRSSED LSAYASISFQ KQPEDRQ
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
