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Protein Overview: IRS1_RAT

General Information:
Name(s) found: IRS1_RAT [Swiss-Prot]
Description(s) found:
Found 19 descriptions.
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  • Insulin receptor substrate 1 OS=Rattus norvegicus GN=Irs1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 1235 amino acids

    Gene Ontology:
    Cellular Component: insulin receptor complex [IMP]
    nucleus [UNKNOWN][ISS]
    caveola [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][ISS]
    microsome [UNKNOWN][IDA][ISS]
    cytosol [UNKNOWN][IDA]
    plasma membrane [UNKNOWN][IDA]
    Biological Process: [NOT]insulin secretion [UNKNOWN]
    insulin receptor signaling pathway [UNKNOWN][IDA][ISS]
    phosphoinositide 3-kinase cascade [UNKNOWN][IEA]
    negative regulation of somatostatin secretion [IMP]
    protein heterooligomerization [IDA]
    negative regulation of insulin secretion [UNKNOWN][IMP]
    positive regulation of glycogen biosynthetic process [UNKNOWN]
    cellular response to insulin stimulus [UNKNOWN]
    response to glucose stimulus [IEP]
    protein kinase B signaling cascade [UNKNOWN][IEA]
    response to insulin stimulus [UNKNOWN][IEP]
    positive regulation of phosphorylation [IDA]
    positive regulation of insulin receptor signaling pathway [IMP]
    signal transduction [IEA]
    positive regulation of fatty acid beta-oxidation [UNKNOWN][IEA]
    positive regulation of phosphoinositide 3-kinase activity [IDA]
    insulin-like growth factor receptor signaling pathway [UNKNOWN][ISS]
    positive regulation of glucose import [UNKNOWN][IEA]
    positive regulation of mesenchymal cell proliferation [UNKNOWN][IEA]
    response to peptide hormone stimulus [IDA]
    negative regulation of insulin receptor signaling pathway [IMP]
    positive regulation of glucose metabolic process [UNKNOWN][IEA]
    mammary gland development [UNKNOWN][IEA]
    positive regulation of glucagon secretion [IMP]
    positive regulation of cell migration [UNKNOWN][IEA]
    Molecular Function: protein kinase C binding [IPI]
    protein kinase binding [UNKNOWN][IPI]
    phosphoinositide 3-kinase binding [UNKNOWN][IDA][IMP][IPI]
    protein domain specific binding [IPI]
    protein binding [UNKNOWN][IDA][IPI]
    insulin-like growth factor receptor activity [IMP]
    insulin receptor binding [UNKNOWN][IMP][ISS]
    SH2 domain binding [IPI]
    signal transducer activity [IEA]
    transmembrane receptor protein tyrosine kinase docking protein activity [IMP]
    insulin-like growth factor receptor binding [UNKNOWN][IPI][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASPPDTDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP  60
   61 KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LQLHNRAKAH 120
  121 HDGAGGGCGG SCSGSSGVGE AGEDLSYDTG PGPAFKEVWQ VILKPKGLGQ TKNLIGIYRL 180
  181 CLTSKTISFV KLNSEAAAVV LQLMNIRRCG HSENFFFIEV GRSAVTGPGE FWMQVDDSVV 240
  241 AQNMHETILE AMRAMSDEFR PRTKSQSSSS CSNPISVPLR RHHLNNPPPS QVGLTRRSRT 300
  301 ESITATSPAS MVGGKPGSFR VRASSDGEGT MSRPASVDGS PVSPSTNRTH AHRHRGSSRL 360
  361 HPPLNHSRSI PMPSSRCSPS ATSPVSLSSS STSGHGSTSD CLFPRRSSAS VSGSPSDGGF 420
  421 ISSDEYGSSP CDFRSSFRSV TPDSLGHTPP ARGEEELSNY ICMGGKGAST LTAPNGHYIL 480
  481 SRGGNGHRYI PGATMGTSPA LTGDEAAGAA DLDNRFRKRT HSAGTSPTIS HQKTPSQSSV 540
  541 VSIEEYTEMM PAAYPPGGGS GGRLPGYRHS AFVPTHSYPE EGLEMHHLER RGGHHRPDSS 600
  601 NLHTDDGYMP MSPGVAPVPS NRKGNGDYMP MSPKSVSAPQ QIINPIRRHP QRVDPNGYMM 660
  661 MSPSGSCSPD IGGGSCSSSS ISAAPSGSSY GKPWTNGVGG HHTHALPHAK PPVESGGGKL 720
  721 LPCTGDYMNM SPVGDSNTSS PSECYYGPED PQHKPVLSYY SLPRSFKHTQ RPGEPEEGAR 780
  781 HQHLRLSSSS GRLRYTATAE DSSSSTSSDS LGGGYCGARP ESSVTHPHHH ALQPHLPRKV 840
  841 DTAAQTNSRL ARPTRLSLGD PKASTLPRVR EQQQQQQQQQ QSSLHPPEPK SPGEYVNIEF 900
  901 GSGQPGYLAG PATSRSSPSV RCLPQLHPAP REETGSEEYM NMDLGPGRRA TWQESGGVEL 960
  961 GRVGPAPPGA ASICRPTRSV PNSRGDYMTM QIGCPRQSYV DTSPVAPVSY ADMRTGIAAE1020
 1021 KVSLPRTTGA APPPSSTASA SASVTPQGAA EQAAHSSLLG GPQGPGGMSA FTRVNLSPNH1080
 1081 NQSAKVIRAD TQGCRRRHSS ETFSAPTRAA NTVSFGAGAA GGGSGGGSED VKRHSSASFE1140
 1141 NVWLRPGDLG GASKESAPGC GAAGGLEKSL NYIDLDLVKD VKQHPQDCPS QQQSLPPPPP1200
 1201 HQPLGSNEGS SPRRSSEDLS TYASINFQKQ PEDRQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle