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Protein Overview: gi|5542106, gi|9...

General Information:
Name(s) found: gi|93278849 [NCBI NR]
gi|73535721 [NCBI NR]
gi|73535690 [NCBI NR]
gi|62738654 [NCBI NR]
gi|55670046 [NCBI NR]
gi|55670045 [NCBI NR]
gi|5542106 [NCBI NR]
gi|47168617 [NCBI NR]
gi|4139918 [NCBI NR]
gi|4139917 [NCBI NR]
gi|4139916 [NCBI NR]
gi|3891990 [NCBI NR]
gi|3891989 [NCBI NR]
gi|3891988 [NCBI NR]
gi|3891974 [NCBI NR]
gi|2914594 [NCBI NR]
gi|2914174 [NCBI NR]
gi|28374048 [NCBI NR]
gi|28374047 [NCBI NR]
gi|28374045 [NCBI NR]
gi|28374044 [NCBI NR]
gi|197305045 [NCBI NR]
gi|157830300 [NCBI NR]
gi|157830148 [NCBI NR]
gi|157830147 [NCBI NR]
gi|157830146 [NCBI NR]
gi|157830088 [NCBI NR]
gi|157830087 [NCBI NR]
gi|157830086 [NCBI NR]
gi|157830085 [NCBI NR]
gi|157830076 [NCBI NR]
gi|114793451 [NCBI NR]
gi|114793448 [NCBI NR]
gi|114793438 [NCBI NR]
Description(s) found:
Found 64 descriptions.
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  • gi|93278849|pdb|2BDL|A Chain A, Cathepsin K Complexed With A Pyrrolidine Ketoamide-Based Inhibitor [NCBI NR]
  • gi|73535721|pdb|1YT7|A Chain A, Cathepsin K Complexed With A Constrained Ketoamide Inhibitor [NCBI NR]
  • gi|73535690|pdb|1YK8|A Chain A, Cathepsin K Complexed With A Cyanamide-Based Inhibitor [NCBI NR]
  • gi|62738654|pdb|1YK7|A Chain A, Cathepsin K Complexed With A Cyanopyrrolidine Inhibitor [NCBI NR]
  • gi|55670046|pdb|1TU6|B Chain B, Cathepsin K Complexed With A Ketoamide Inhibitor [NCBI NR]
  • gi|55670045|pdb|1TU6|A Chain A, Cathepsin K Complexed With A Ketoamide Inhibitor [NCBI NR]
  • gi|5542106|pdb|1BGO| Chain , Crystal Structure Of Cysteine Protease Human Cathepsin K In Complex With A Covalent Peptidomimetic Inhibitor [NCBI NR]
  • gi|47168617|pdb|1Q6K|A Chain A, Cathepsin K Complexed With T-Butyl(1s)-1-Cyclohexyl-2- Oxoethylcarbamate [NCBI NR]
  • gi|4139918|pdb|1AYW| Chain , Crystal Structure Of Cysteine Protease Human Cathepsin K In Complex With A Covalent Benzyloxybenzoylcarbohydrazide Inhibitor [NCBI NR]
  • gi|4139917|pdb|1AYV| Chain , Crystal Structure Of Cysteine Protease Human Cathepsin K In Complex With A Covalent Thiazolhydrazide Inhibitor [NCBI NR]
  • gi|4139916|pdb|1AYU| Chain , Crystal Structure Of Cysteine Protease Human Cathepsin K In Complex With A Covalent Symmetric Biscarbohydrazide Inhibitor [NCBI NR]
  • gi|3891990|pdb|1AU3| Chain , Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Pyrrolidinone Inhibitor [NCBI NR]
  • gi|3891989|pdb|1AU2| Chain , Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Propanone Inhibitor [NCBI NR]
  • gi|3891988|pdb|1AU0| Chain , Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Symmetric Diacylaminomethyl Ketone Inhibitor [NCBI NR]
  • gi|3891974|pdb|1AU4| Chain , Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Pyrrolidinone Inhibitor [NCBI NR]
  • gi|2914594|pdb|1MEM|A Chain A, Crystal Structure Of Cathepsin K Complexed With A Potent Vinyl Sulfone Inhibitor [NCBI NR]
  • gi|2914174|pdb|1ATK| Chain , Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With The Covalent Inhibitor E-64 [NCBI NR]
  • gi|28374048|pdb|1NLJ|B Chain B, Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor [NCBI NR]
  • gi|28374047|pdb|1NLJ|A Chain A, Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor [NCBI NR]
  • gi|28374045|pdb|1NL6|B Chain B, Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor [NCBI NR]
  • gi|28374044|pdb|1NL6|A Chain A, Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Azepanone Inhibitor [NCBI NR]
  • gi|197305045|pdb|3C9E|A Chain A, Crystal Structure Of The Cathepsin K : Chondroitin Sulfate Complex [NCBI NR]
  • gi|157830300|pdb|1BGO|A Chain A, Crystal Structure Of Cysteine Protease Human Cathepsin K In Complex With A Covalent Peptidomimetic Inhibitor [NCBI NR]
  • gi|157830148|pdb|1AYW|A Chain A, Crystal Structure Of Cysteine Protease Human Cathepsin K In Complex With A Covalent Benzyloxybenzoylcarbohydrazide Inhibitor [NCBI NR]
  • gi|157830147|pdb|1AYV|A Chain A, Crystal Structure Of Cysteine Protease Human Cathepsin K In Complex With A Covalent Thiazolhydrazide Inhibitor [NCBI NR]
  • gi|157830146|pdb|1AYU|A Chain A, Crystal Structure Of Cysteine Protease Human Cathepsin K In Complex With A Covalent Symmetric Biscarbohydrazide Inhibitor [NCBI NR]
  • gi|157830088|pdb|1AU4|A Chain A, Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Pyrrolidinone Inhibitor [NCBI NR]
  • gi|157830087|pdb|1AU3|A Chain A, Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Pyrrolidinone Inhibitor [NCBI NR]
  • gi|157830086|pdb|1AU2|A Chain A, Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Propanone Inhibitor [NCBI NR]
  • gi|157830085|pdb|1AU0|A Chain A, Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With A Covalent Symmetric Diacylaminomethyl Ketone Inhibitor [NCBI NR]
  • gi|157830076|pdb|1ATK|A Chain A, Crystal Structure Of The Cysteine Protease Human Cathepsin K In Complex With The Covalent Inhibitor E-64 [NCBI NR]
  • gi|114793451|pdb|2AUZ|A Chain A, Cathepsin K Complexed With A Semicarbazone Inhibitor [NCBI NR]
  • gi|114793448|pdb|2AUX|A Chain A, Cathepsin K Complexed With A Semicarbazone Inhibitor [NCBI NR]
  • gi|114793438|pdb|2ATO|A Chain A, Crystal Structure Of Human Cathepsin K In Complex With Myocrisin [NCBI NR]
    • Organism: Homo sapiens
    Length: 215 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APDSVDYRKK GYVTPVKNQG QCGSCWAFSS VGALEGQLKK KTGKLLNLSP QNLVDCVSEN  60
   61 DGCGGGYMTN AFQYVQKNRG IDSEDAYPYV GQEESCMYNP TGKAAKCRGY REIPEGNEKA 120
  121 LKRAVARVGP VSVAIDASLT SFQFYSKGVY YDESCNSDNL NHAVLAVGYG IQKGNKHWII 180
  181 KNSWGENWGN KGYILMARNK NNACGIANLA SFPKM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. gi|112491310 gi|13786858 gi|150261449 gi|219109210, gi... gi|5542106, gi|9... gi|56554577

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 69.69897 (Pro)cathepsin K

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  3.44939172906839 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  3.19661661746208 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  2.44287562275675 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.21825711544542 bayes_pls_golite062009
  • hydrolase activity
    		•  2.12149168638347 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.56440572494467 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • binding
    		•  0.325252559537201 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  0.169941298760462 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle