YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|5542106, gi\|9...
Organism:	Homo sapiens
Length:	215 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|5542106, gi|9....

Description	E-value	Query Range	Subject Range
gi\|55740406 - gi\|55740406\|gb\|AAV63979.1\| cathepsin L1 precursor [Artemia parthenogenetica]	280.0	[0..2]	[215..123]
gi\|157132324, gi... - gi\|157132324\|ref\|XP_001655999.1\| cathepsin l [Aedes aegypti], gi\|108881694\|gb\|EAT45919.1\| cathepsin ...	279.0	[0..2]	[215..123]
gi\|55740402 - gi\|55740402\|gb\|AAV63977.1\| cathepsin L precursor [Artemia franciscana]	279.0	[0..2]	[215..123]
gi\|115956743 - gi\|115956743\|ref\|XP_001186372.1\| PREDICTED: similar to cathepsin l [Strongylocentrotus purpuratus]	277.0	[0..2]	[215..607]
gi\|58394363, gi\|... - gi\|58394363\|ref\|XP_320687.2\| ENSANGP00000020002 [Anopheles gambiae str. PEST], gi\|55234845\|gb\|EAA003...	276.0	[0..2]	[215..162]
gi\|125811035, gi... - gi\|54636903\|gb\|EAL26306.1\| GA20520-PA [Drosophila pseudoobscura], gi\|125811035\|ref\|XP_001361728.1\| G...	273.0	[0..2]	[214..125]
gi\|33348836 - gi\|33348836\|gb\|AAQ16118.1\| cathepsin L-like cysteine proteinase B [Rhipicephalus haemaphysaloides ha...	271.0	[0..2]	[215..120]

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Predicted Domain #1

Region A:
Residues: [1-215]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APDSVDYRKK GYVTPVKNQG QCGSCWAFSS VGALEGQLKK KTGKLLNLSP QNLVDCVSEN  60
   61 DGCGGGYMTN AFQYVQKNRG IDSEDAYPYV GQEESCMYNP TGKAAKCRGY REIPEGNEKA 120
  121 LKRAVARVGP VSVAIDASLT SFQFYSKGVY YDESCNSDNL NHAVLAVGYG IQKGNKHWII 180
  181 KNSWGENWGN KGYILMARNK NNACGIANLA SFPKM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.69897
Match:	1by8A
Description:	(Pro)cathepsin K
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	3.44939172906839	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.19661661746208	bayes_pls_golite062009
cysteine-type peptidase activity	2.44287562275675	bayes_pls_golite062009
endopeptidase activity	2.21825711544542	bayes_pls_golite062009
hydrolase activity	2.12149168638347	bayes_pls_golite062009
cysteine-type endopeptidase activity	1.56440572494467	bayes_pls_golite062009
catalytic activity	1.05972260874031	bayes_pls_golite062009
binding	0.325252559537201	bayes_pls_golite062009
small conjugating protein-specific protease activity	0.169941298760462	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: