YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|39812229, gi\|...
Organism:	Homo sapiens
Length:	539 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|39812229, gi|....

Description	E-value	Query Range	Subject Range
gi\|66392219, gi\|... - gi\|66392219\|ref\|NP_001018163.1\| karyopherin alpha 5 [Danio rerio], gi\|63100717\|gb\|AAH95356.1\| Zgc:11...	0.0	[1..539]	[1..539]
gi\|45126627 - gi\|45126627\|emb\|CAD89699.1\| importin alpha 5.1 protein [Xenopus laevis]	0.0	[1..539]	[1..537]
gi\|56118574, gi\|... - gi\|56118574\|ref\|NP_001008018.1\| kpna6 protein [Xenopus (Silurana) tropicalis], gi\|51895910\|gb\|AAH808...	0.0	[4..539]	[1..534]
IMA1_MOUSE - Importin subunit alpha-1 OS=Mus musculus GN=Kpna2 PE=1 SV=2 gi\|53733645 - gb\|AAH83956.1\| Unknown (protein for MGC:97971) [Xenopus laevis]	0.0	[1..538]	[1..528]
gi\|59800319, gi\|... - gi\|59800319\|gb\|AAX07453.1\| karyopherin alpha 2 [Rattus norvegicus], gi\|58477719\|gb\|AAH89787.1\| Karyo...	0.0	[1..538]	[1..528]
gi\|73950007, gi\|... - gi\|73950007\|ref\|XP_864825.1\| PREDICTED: similar to Importin alpha-7 subunit (Karyopherin alpha-6) is...	0.0	[1..539]	[1..536]
IMA7_BOVIN - Importin subunit alpha-7 OS=Bos taurus GN=KPNA6 PE=2 SV=1	0.0	[1..539]	[1..536]
gi\|61361768, gi\|... - gi\|61361768\|gb\|AAX42100.1\| karyopherin alpha 2 [synthetic construct], gi\|124126887\|gb\|ABM92216.1\| ka... gi\|30582169, gi\|... - gi\|30582169\|gb\|AAP35311.1\| karyopherin alpha 2 (RAG cohort 1, importin alpha 1) [Homo sapiens], gi\|1...	0.0	[1..538]	[1..528]

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Predicted Domain #1

Region A:
Residues: [1-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAMASPGKD NYRMKSYKNK ALNPQEMRRR REEEGIQLRK QKREEQLFKR RNVYLPRNDE  60
   61 SMLESPIQDP DISSTVPIPE EEVVTTDMVQ MIFSNNADQQ LTATQKFRKL LSKEPNPPID 120
  121 QVIQKPGVVQ RFVKFLERNE NCTLQFEAAW ALTNIASGTF LHTKVVIETG AVPIFIKLLN 180
  181 SEHEDVQEQA VWALGNIAGD NAECRDFVLN CEILPPLLEL LTNSNRLTTT RNAVWALSNL 240
  241 CRGKNPPPNF SKVSPCLNVL SRLLFSSDPD VLADVCWALS YLSDGPNDKI QAVIDSGVCR 300
  301 RLVELLMHND YKVVSPALRA VGNIVTGDDI QTQVILNCSA LPCLLHLLSS PKESIRKEAC 360
  361 WTVSNITAGN RAQIQAVIDA NIFPVLIEIL QKAEFRTRKE AAWAITNATS GGTPEQIRYL 420
  421 VALGCIKPLC DLLTVMDSKI VQVALNGLEN ILRLGEQESK QNG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.09691
Match:	1qbkB
Description:	Karyopherin beta2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	4.58709163830613	bayes_pls_golite062009
nuclear export signal receptor activity	3.48172991171337	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
actin binding	2.8014924948341	bayes_pls_golite062009
nucleic acid binding	2.74745843355294	bayes_pls_golite062009
protein transmembrane transporter activity	2.74547353635661	bayes_pls_golite062009
cytoskeletal protein binding	2.61566088685247	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
transcription regulator activity	2.16673352512615	bayes_pls_golite062009
DNA binding	1.95242774903625	bayes_pls_golite062009
nuclear localization sequence binding	1.91487015967262	bayes_pls_golite062009
protein binding	1.73688475473996	bayes_pls_golite062009
molecular transducer activity	1.32874350341969	bayes_pls_golite062009
signal transducer activity	1.32874350341969	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
transcription factor activity	1.20660383756339	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
signal sequence binding	0.57106697498903	bayes_pls_golite062009
RNA binding	0.40024158562931	bayes_pls_golite062009
structural molecule activity	0.279926218252647	bayes_pls_golite062009
importin-alpha export receptor activity	0.259676026705859	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
transcription activator activity	0.160275383613705	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009
transcription factor binding	0.0221966060394205	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [464-539]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGINPYCALI EEAYGLDKIE FLQSHENQEI YQKAFDLIEH YFGVEEDDPS IVPQVDENQQ  60
   61 QFIFQQQEAP MDGFQL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.63
Match:	1q1sC
Description:	Mouse Importin alpha- phosphorylated SV40 CN peptide complex
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: