YRC Public Data Repository - Protein Structure Prediction

Protein:	NTRC_ECOLI
Organism:	Escherichia coli
Length:	469 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NTRC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|237702900, gi... - gi\|237702900\|ref\|ZP_04533381.1\| nitrogen regulation protein NR(I) [Escherichia sp. 3_2_53FAA], gi\|22... gi\|91074988, gi\|... - gi\|91213414\|ref\|YP_543400.1\| nitrogen regulation protein NR(I) [Escherichia coli UTI89], gi\|91074988...	418.0	[0..1]	[469..21]
gi\|162138321 - gi\|162138321\|ref\|YP_543400.2\| nitrogen regulation protein NR(I) [Escherichia coli UTI89] gi\|218367712, gi... - gi\|218560943\|ref\|YP_002393856.1\| nitrogen regulation protein NR(I) [Escherichia coli S88], gi\|218367... gi\|75237833 - gi\|75237833\|ref\|ZP_00721848.1\| COG2204: Response regulator containing CheY-like receiver, AAA-type A... gi\|115515265, gi... - gi\|117626141\|ref\|YP_859464.1\| nitrogen regulation protein NR(I) [Escherichia coli APEC O1], gi\|11551...	418.0	[0..1]	[469..1]
gi\|75513983, gi\|... - gi\|75513983\|ref\|ZP_00736336.1\| COG2204: Response regulator containing CheY-like receiver, AAA-type A...	417.0	[0..1]	[469..1]
gi\|209921342, gi... - gi\|209921342\|ref\|YP_002295426.1\| nitrogen regulation protein NR(I) [Escherichia coli SE11], gi\|20991... gi\|83586283 - gi\|83586283\|ref\|ZP_00924919.1\| COG2204: Response regulator containing CheY-like receiver, AAA-type A... gi\|124501233, gi... - gi\|124527531\|ref\|ZP_01698996.1\| nitrogen metabolism transcriptional regulator, NtrC, Fis Family [Esc... gi\|218697581, gi... - gi\|218697581\|ref\|YP_002405248.1\| nitrogen regulation protein NR(I) [Escherichia coli 55989], gi\|2183... gi\|170022118, gi... - gi\|170022118\|ref\|YP_001727072.1\| nitrogen regulation protein NR(I) [Escherichia coli ATCC 8739], gi\|... gi\|75230388 - gi\|75230388\|ref\|ZP_00716874.1\| COG2204: Response regulator containing CheY-like receiver, AAA-type A... gi\|75258150 - gi\|75258150\|ref\|ZP_00729611.1\| COG2204: Response regulator containing CheY-like receiver, AAA-type A... gi\|157155281, gi... - gi\|75188602\|ref\|ZP_00701869.1\| COG2204: Response regulator containing CheY-like receiver, AAA-type A... gi\|75210115 - gi\|75210115\|ref\|ZP_00710294.1\| COG2204: Response regulator containing CheY-like receiver, AAA-type A... gi\|73857850, gi\|... - gi\|74314373\|ref\|YP_312792.1\| nitrogen regulation protein NR(I) [Shigella sonnei Ss046], gi\|73857850\|... gi\|81247623, gi\|... - gi\|82546212\|ref\|YP_410159.1\| nitrogen regulation protein NR(I) [Shigella boydii Sb227], gi\|81247623\|...	417.0	[0..1]	[469..1]
gi\|26111063, gi\|... - gi\|26250632\|ref\|NP_756672.1\| Nitrogen regulation protein NR(I) [Escherichia coli CFT073], gi\|2611106...	416.0	[0..1]	[469..21]
gi\|110644208, gi... - gi\|110644208\|ref\|YP_671938.1\| nitrogen regulation protein NR(I) [Escherichia coli 536], gi\|110345800...	416.0	[0..1]	[469..1]
gi\|15804453, gi\|... - gi\|15804453\|ref\|NP_290493.1\| nitrogen regulation protein NR(I) [Escherichia coli O157:H7 EDL933], gi... gi\|25301123 - gi\|25301123\|pir\|\|E86074 hypothetical protein glnG [imported] - Escherichia coli (strain O157:H7, su...	416.0	[0..1]	[469..1]
gi\|56480461, gi\|... - gi\|56480461\|ref\|NP_709666.2\| nitrogen regulation protein NR(I) [Shigella flexneri 2a str. 301], gi\|5... gi\|110616996, gi... - gi\|110807448\|ref\|YP_690968.1\| nitrogen regulation protein NR(I) [Shigella flexneri 5 str. 8401], gi\|... gi\|30043103, gi\|... - gi\|30064843\|ref\|NP_839014.1\| nitrogen regulation protein NR(I) [Shigella flexneri 2a str. 2457T], gi...	416.0	[0..1]	[469..1]
gi\|62182467, gi\|... - gi\|62182467\|ref\|YP_218884.1\| response regulator in two-component regulatory system with GlnL (EBP fa...	416.0	[0..1]	[469..20]
gi\|187430426, gi... - gi\|75176747\|ref\|ZP_00696875.1\| COG2204: Response regulator containing CheY-like receiver, AAA-type A...	416.0	[0..1]	[469..1]

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Predicted Domain #1

Region A:
Residues: [1-388]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRGIVWVVD DDSSIRWVLE RALAGAGLTC TTFENGAEVL EALASKTPDV LLSDIRMPGM  60
   61 DGLALLKQIK QRHPMLPVII MTAHSDLDAA VSAYQQGAFD YLPKPFDIDE AVALVERAIS 120
  121 HYQEQQQPRN VQLNGPTTDI IGEAPAMQDV FRIIGRLSRS SISVLINGES GTGKELVAHA 180
  181 LHRHSPRAKA PFIALNMAAI PKDLIESELF GHEKGAFTGA NTIRQGRFEQ ADGGTLFLDE 240
  241 IGDMPLDVQT RLLRVLADGQ FYRVGGYAPV KVDVRIIAAT HQNLEQRVQE GKFREDLFHR 300
  301 LNVIRVHLPP LRERREDIPR LARHFLQVAA RELGVEAKLL HPETEAALTR LAWPGNVRQL 360
  361 ENTCRWLTVM AAGQEVLIQD LPGELFES

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.69897
Match:	1ny5A
Description:	Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein histidine kinase activity	2.35011582062573	bayes_pls_golite062009
two-component sensor activity	2.32303301074957	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.28838869071567	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.95073642969863	bayes_pls_golite062009
pyrophosphatase activity	1.91141407779641	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.9017593265179	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.90014393273511	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	1.82370030183942	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.79922369980544	bayes_pls_golite062009
transporter activity	1.55572428045529	bayes_pls_golite062009
amino acid transmembrane transporter activity	1.52217781539459	bayes_pls_golite062009
ATPase activity	1.48474288797022	bayes_pls_golite062009
two-component response regulator activity	1.45919623810582	bayes_pls_golite062009
amine transmembrane transporter activity	1.4031990658196	bayes_pls_golite062009
transmembrane transporter activity	1.38483976298883	bayes_pls_golite062009
ATPase activity, coupled	1.37457738689583	bayes_pls_golite062009
catalytic activity	1.37148167194523	bayes_pls_golite062009
binding	1.30574971150356	bayes_pls_golite062009
active transmembrane transporter activity	1.24278046928678	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.2014318795788	bayes_pls_golite062009
primary active transmembrane transporter activity	1.19670408144267	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	1.17063957238561	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	1.16918853509059	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	1.16885789920943	bayes_pls_golite062009
hydrolase activity	1.09839981963412	bayes_pls_golite062009
nucleic acid binding	0.900561861643259	bayes_pls_golite062009
transcription regulator activity	0.530058973650498	bayes_pls_golite062009
purine ribonucleotide binding	0.5127850474754	bayes_pls_golite062009
ribonucleotide binding	0.51230334374838	bayes_pls_golite062009
purine nucleotide binding	0.50688037036449	bayes_pls_golite062009
protein binding	0.502813311049029	bayes_pls_golite062009
nucleotide binding	0.49473184426584	bayes_pls_golite062009
DNA binding	0.460315660888175	bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity	0.32754685224555	bayes_pls_golite062009
amine-transporting ATPase activity	0.128277449580549	bayes_pls_golite062009
amino acid-transporting ATPase activity	0.109938795198381	bayes_pls_golite062009
substrate-specific transporter activity	0.0838665746103899	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [389-469]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVAESTSQMQ PDSWATLLAQ WADRALRSGH QNLLSEAQPE LERTLLTTAL RHTQGHKQEA  60
   61 ARLLGWGRNT LTRKLKELGM E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.69897
Match:	1ojlA
Description:	Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: