YRC Public Data Repository - Protein Structure Prediction

Protein:	EAF1
Organism:	Saccharomyces cerevisiae
Length:	982 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EAF1.

Description	E-value	Query Range	Subject Range
EAF1_YEAST - Chromatin modification-related protein EAF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... EAF1 - Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 sub... gi\|190404705 - gi\|190404705\|gb\|EDV07972.1\| hypothetical protein SCRG_00173 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..982]	[1..982]
VID21_ASHGO - Chromatin modification-related protein VID21 OS=Ashbya gossypii GN=VID21 PE=3 SV=1 EAF1_ASHGO - Chromatin modification-related protein EAF1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGS...	0.0	[15..982]	[4..953]
VID21_GIBZE - Chromatin modification-related protein VID21 OS=Gibberella zeae GN=VID21 PE=3 SV=1 AEF1_GIBZE - Chromatin modification-related protein EAF1 OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9...	0.0	[2..828]	[450..1239]
VID21_EMENI, EAF... - Chromatin modification-related protein vid21 OS=Emericella nidulans GN=vid21 PE=3 SV=1, Chromatin mo... EAF1_EMENI - Chromatin modification-related protein eaf1 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CB...	0.0	[5..869]	[237..1099]
EAF1_NEUCR - Chromatin modification-related protein eaf-1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / ... VID21_NEUCR - Chromatin modification-related protein vid-21 OS=Neurospora crassa GN=vid-21 PE=3 SV=1	0.0	[69..842]	[459..1215]
EAF1_CANAL - Chromatin modification-related protein EAF1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=E... VID21_CANAL - Chromatin modification-related protein VID21 OS=Candida albicans GN=VID21 PE=3 SV=1	2.0E-88	[533..825]	[248..547]
gi\|7959257 - gi\|7959257\|dbj\|BAA96022.1\| KIAA1498 protein [Homo sapiens]	4.0E-62	[64..431]	[463..843]
gi\|27348237, gi\|... - gi\|27414493\|ref\|NP_083613.1\| Domino [Mus musculus], gi\|27348237\|dbj\|BAC45253.1\| mDomino [Mus musculu...	2.0E-60	[64..431]	[462..840]
VID21_USTMA - Chromatin modification-related protein VID21 OS=Ustilago maydis GN=VID21 PE=3 SV=1 EAF11_USTMA - Chromatin modification-related protein EAF1 OS=Ustilago maydis (strain 521 / FGSC 9021) GN=EAF1 PE=3...	5.0E-55	[41..522]	[212..713]

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Predicted Domain #1

Region A:
Residues: [1-95]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRPSSAVP NSASLSEDQS SDRSKFPKAD DLIDERDRKL TELYCVSRLN QLLELTDENK  60
   61 LRKEIDAFLK KNDIRRGIRF DEASLPKLLH TAATP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [96-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITKKKLKDVN LINVPNQRLS DSKMSRELPE NSENVSVKSE SHFVPSHDNS IRENMMDSLR  60
   61 PAEKTGGMWN KRPLESTMGG EEERHEKRQK MQSQSLESSN NSEMASLPIS PRPPVPNALA 120
  121 HYTYYENIEY PPADPTEVQP AVKFKDPLIK NIMAKEIDTS DHYNENNVDA LETVFLLMND 180
  181 YIPSKIPQAL PLAELKYMSQ TLPLINLIPR AHKALTT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.287	N/A	N/A	d.58.4	Dimeric alpha+beta barrel

Predicted Domain #3

Region A:
Residues: [313-480]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIINNALNEA RITVVGSRIE ELRRLGLWSL RQPKRFIDPW KQHNTHQNIL LEEAKWMQAD  60
   61 FKEGHKYKVA ICTAMAQAIK DYWTYGEICC VKRKTLLPGK ENKLSDDGRI SEKSGRPSDT 120
  121 SRNDSDISIA GKDDIGIIAN VDDITEKESA AANDNDENGK NEAGAKSD

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	28.853872
Match:	PF07529.1
Description:	No description for PF07529.1 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.689	N/A	N/A	d.19.1	MHC antigen-recognition domain
View	Download	0.516	N/A	N/A	a.1.1	Globin-like
View	Download	0.451	N/A	N/A	d.19.1	MHC antigen-recognition domain
View	Download	0.397	N/A	N/A	d.19.1	MHC antigen-recognition domain
View	Download	0.395	N/A	N/A	a.1.1	Globin-like

Predicted Domain #4

Region A:
Residues: [481-707]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDFADGLLSQ EGAHDQIISS IDTKLLLKKP SSSSEVVLIQ HEVAASSALI ETEESKKELA  60
   61 PPFKLSIFVD ELNTFEKTLI QDLPLYNGIN EERPKKDDSL PFIPISKSVV SLDDNGFYKL 120
  121 LERQLIDEEP SISQLSKRRG MFYGNRRNHY LRPPAVPSLR YLQNRTPTIW LSEDDQELVK 180
  181 NINTYGYNWE LISAHMTHRL TYSYLSNIER RTPWQCFERF VQLNERF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [708-834]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFSDLKGPRA HSAQQWLIEA HKFQQRQNRR ISPLGVNTES IQRGHRRLRW ASMFEAIRKC  60
   61 MKKRENTPRP NPTQPRKPLD CKNMKVPTPA EMSLLKAQRD EALRRDIQLR RTVKNRLQQR 120
  121 QQQSQQA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
histone acetyltransferase activity	5.78270240334849	bayes_pls_golite062009
lysine N-acetyltransferase activity	5.78270240334849	bayes_pls_golite062009
N-acyltransferase activity	4.53404381270892	bayes_pls_golite062009
N-acetyltransferase activity	4.38345537045529	bayes_pls_golite062009
acetyltransferase activity	3.81897719505269	bayes_pls_golite062009
acyltransferase activity	3.35931919126926	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	3.31384699789032	bayes_pls_golite062009
transferase activity, transferring acyl groups	3.09869056563841	bayes_pls_golite062009
transcription regulator activity	3.05971315776284	bayes_pls_golite062009
DNA binding	2.98143466641891	bayes_pls_golite062009
nucleic acid binding	2.85666780317594	bayes_pls_golite062009
binding	2.77786931095369	bayes_pls_golite062009
transcription factor activity	2.3234819540139	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.90050165838755	bayes_pls_golite062009
chromatin binding	1.46306211220814	bayes_pls_golite062009
sequence-specific DNA binding	1.23729321119532	bayes_pls_golite062009
protein deacetylase activity	1.23476914879396	bayes_pls_golite062009
histone deacetylase activity	1.18710646783152	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.02200659886159	bayes_pls_golite062009
protein binding	1.00288283679871	bayes_pls_golite062009
transcription repressor activity	0.700409976805769	bayes_pls_golite062009
transcription activator activity	0.58607600202198	bayes_pls_golite062009
structure-specific DNA binding	0.559482273209868	bayes_pls_golite062009
deacetylase activity	0.534082291544628	bayes_pls_golite062009
histone binding	0.489784140732052	bayes_pls_golite062009
transcription factor binding	0.270053518126008	bayes_pls_golite062009
double-stranded DNA binding	0.0110175210304684	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [835-982]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSSRAQSPIP SNGKSSSNLA RNGQASAPRP NQKQYTEQDI IESYSRKLLE QKPDIGPEMA  60
   61 LKAAKNYYRT LREQQQQLKQ HQIQQQRQQL QEESSHVQQL QQLQPGSQAP PPKSSPSQSS 120
  121 LSNISNINSA PRIKSPTPQE ILQRFQKQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.407	a.22.1	Histone-fold
View	Download	0.309	a.22.1	Histone-fold
View	Download	0.286	a.29.5	alpha-ketoacid dehydrogenase kinase, N-terminal domain
View	Download	0.272	a.19.1	Fertilization protein
View	Download	0.251	a.22.1	Histone-fold

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: