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View Structure Prediction Details

Protein: C96AF_ARATH
Organism: Arabidopsis thaliana
Length: 497 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for C96AF_ARATH.

Description E-value Query
Range
Subject
Range
CYP2C8 - cytochrome P450, family 2, subfamily C, polypeptide 8
363.0 [0..1] [495..1]

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Predicted Domain #1
Region A:
Residues: [1-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMLGFYVTF IFFLVCLFTY FFLQKKPQGQ PILKNWPFLR MLPGMLHQIP RIYDWTVEVL  60
   61 EATNLTFYFK GPWLSGTDML FTADPRNIHH ILSSNFGNYP KGPEFKKIFD VLGEGILTVD 120
  121 FELWEEMRKS NHALFHNQDF IELSVSSNKS KLKEGLVPFL DNAAQKNIII ELQDVFQRFM 180
  181 FDTSSILMTG YDPMSLSIEM LEVEFGEAAD IGEEAIYYRH FKPVILWRLQ NWIGIGLERK 240
  241 MRTALATVNR MFAKIISSRR KEEISRAKTE PYSKDALTYY MNVDTSKYKL LKPNKDKFIR 300
  301 DVIFSLVLAG RDTTSSVLTW FFWLLSKHPQ VMAKLRHEIN TKFDNEDLEK LVYLHAALSE 360
  361 SMRLYPPLPF NHKSPAKPDV LPSGHKVDAN SKIVICIYAL GRMRSVWGED ALDFKPERWI 420
  421 SDNGGLRHEP SYKFMAFNSG PRTCLGKNLA LLQMKMVALE IIRNYDFKVI EGHKVEPIPS 480
  481 ILLRMKHGLK VTVTKKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 95.69897
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
fatty acid (omega-1)-hydroxylase activity 6.3313834755701 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
arachidonic acid monooxygenase activity 3.03830845324387 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.41884363121524 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.27465774301343 bayes_pls_golite062009
demethylase activity 2.17116413461366 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 1.71732865382274 bayes_pls_golite062009
sterol 14-demethylase activity 1.68985995159863 bayes_pls_golite062009
oxygen binding 1.66120675703571 bayes_pls_golite062009
retinoid binding 1.55427837836259 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 1.48500938886158 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
isoprenoid binding 1.43053384013166 bayes_pls_golite062009
arachidonic acid epoxygenase activity 1.4220050618113 bayes_pls_golite062009
retinoic acid binding 1.21667685596765 bayes_pls_golite062009
binding 1.0881336564542 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.04852693766796 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.918503562996019 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009

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