YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC12C2.11
Organism:	Schizosaccharomyces pombe
Length:	696 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC12C2.11.

Description	E-value	Query Range	Subject Range
gi\|115400874, gi... - gi\|115400874\|ref\|XP_001216025.1\| glucosamine--fructose-6-phosphate aminotransferase [Aspergillus ter...	570.0	[0..1]	[696..1]
gi\|190409730 - gi\|190409730\|gb\|EDV12995.1\| glucoseamine-6-phosphate synthase [Saccharomyces cerevisiae RM11-1a] gi\|151941699 - gi\|151941699\|gb\|EDN60061.1\| glucosamine-6-phosphate synthase [Saccharomyces cerevisiae YJM789] GFA1 - Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glut... GFA1_YEAST - Glutamine--fructose-6-phosphate aminotransferase [isomerizing] OS=Saccharomyces cerevisiae (strain A... gi\|207343559 - gi\|207343559\|gb\|EDZ70990.1\| YKL104Cp-like protein [Saccharomyces cerevisiae AWRI1631]	570.0	[0..1]	[696..1]
gi\|134084732, gi... - gi\|51440693\|gb\|AAU01572.1\| glutamine:fructose-6-phosphate amidotransferase [Aspergillus niger], gi\|1... gi\|145255893 - gi\|145255893\|ref\|XP_001399135.1\| hypothetical protein An18g06820 [Aspergillus niger]	569.0	[0..1]	[696..1]
gi\|28564365 - gi\|28564365\|gb\|AAO32496.1\| GFA1 [Saccharomyces castellii]	565.0	[0..1]	[696..1]
gi\|169769551 - gi\|169769551\|ref\|XP_001819245.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|238488132, gi... - gi\|238488132\|ref\|XP_002375304.1\| glucosamine-fructose-6-phosphate aminotransferase [Aspergillus flav... gi\|83767104 - gi\|83767104\|dbj\|BAE57243.1\| unnamed protein product [Aspergillus oryzae]	565.0	[0..1]	[696..1]
gi\|44980852 - gi\|44980852\|gb\|AAS50735.1\| ABL036Cp [Ashbya gossypii ATCC 10895] gi\|45185194, gi\|... - gi\|45185194\|ref\|NP_982911.1\| ABL036Cp [Ashbya gossypii ATCC 10895], gi\|44980852\|gb\|AAS50735.1\| ABL03...	563.0	[0..1]	[696..1]
gi\|49644828\|emb\|... - unnamed protein product [Kluyveromyces lactis NRRL Y-1140] gi\|49644828, gi\|... - gi\|50311335\|ref\|XP_455692.1\| unnamed protein product [Kluyveromyces lactis], gi\|49644828\|emb\|CAG9840...	560.0	[0..1]	[696..1]
gi\|49527905 - gi\|49527905\|emb\|CAG61556.1\| unnamed protein product [Candida glabrata] gi\|50292321, gi\|... - gi\|50292321\|ref\|XP_448593.1\| unnamed protein product [Candida glabrata], gi\|49527905\|emb\|CAG61556.1\|...	559.0	[0..1]	[696..1]
gi\|53987049 - gi\|53987049\|tpg\|DAA05487.1\| TPA: TPA_inf: glutamine:fructose-6-phosphate amidotransferase [Aspergill... gi\|57236783 - gi\|57236783\|gb\|AAW49003.1\| glutamine-fructose-6-phosphate transaminase [Emericella nidulans]	558.0	[0..1]	[696..1]

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Predicted Domain #1

Region A:
Residues: [1-233]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCGIFGYINY LVERDRGYIL KTLVKGLKRL EYRGYDSSGC AVDGDEGEDF IMFKEVGNVS  60
   61 KLEASIKGSN VNKSTKFINH CAISHTRWAT HGIPSPINCH PQRSDPHSEF IVVHNGILTN 120
  121 YRELRTVLES RGMVFESETD TECVAKLAKF IYDTTPGVDF TSLAKLVFRE LEGAYALLIK 180
  181 SSHYPGEVVA TRRGSPLIVG VKSEQKLKVD FVDVEFPEPA EGLPGTPKPT SLH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.0
Match:	1xffA
Description:	Glutaminase domain of glucosamine 6-phosphate synthase complexed with glutamate
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	1.34295853726897	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	1.16226272745141	bayes_pls_golite062009
nucleic acid binding	0.798789250029517	bayes_pls_golite062009
endopeptidase activity	0.759765292911898	bayes_pls_golite062009
binding	0.541510243044181	bayes_pls_golite062009
transferase activity	0.526806728662348	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [234-347]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVFSNPATNG MLRGDKPDLL HRAQSRAFVS GEGVPGPIEY FFASDATPII EYTKRVMFLE  60
   61 DDDIAHVRDG ELHVHRLRRE GGGSTTRTIE TLEMEIASVM KGNYDHYMIK EICE

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.54
Match:	1jxaA
Description:	"Isomerase domain" of glucosamine 6-phosphate synthase (GLMS); Glucosamine 6-phosphate synthase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [348-645]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPDSLLNTMR GRVNFVNRLV TLGGLESYYD IIRKSRRLIF VACGTSYHSC VAVRPLFEEL  60
   61 TNIPVVVELA SDFVDRCPSV FRDDTFIFVS QSGETADSLL ALQYTLENGA LAIGVVNCVG 120
  121 SSISRKTHCG VHINAGPEIC VASTKAYTSQ YVALVLMALY LSRDSVSRLE RRNEIIDGLA 180
  181 EIGEKVQETL HLNAAIKQTA IEQLINKDKM LIIGRGYHYA TALEGALKVK EISYTHAEGV 240
  241 LAGELKHGVL ALVDNDMPIV MLLPDDYNFP KAWNAFEQVR ARGGKPIIIT DKKLDNLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.522879
Match:	1tzbA
Description:	Crystal structure of native phosphoglucose/phosphomannose isomerase from Pyrobaculum aerophilum
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutamine-fructose-6-phosphate transaminase (isomerizing) activity	4.12465195642555	bayes_pls_golite062009
glucose-6-phosphate isomerase activity	2.74527495029339	bayes_pls_golite062009
D-sedoheptulose 7-phosphate isomerase activity	2.03357282678145	bayes_pls_golite062009
intramolecular oxidoreductase activity	1.99606027864666	bayes_pls_golite062009
catalytic activity	1.5278037255884	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	1.49939040101274	bayes_pls_golite062009
sugar binding	1.40175307923331	bayes_pls_golite062009
transferase activity	1.20219571915061	bayes_pls_golite062009
isomerase activity	0.875614547872629	bayes_pls_golite062009
binding	0.8320110584046	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	0.329741341879618	bayes_pls_golite062009
transaminase activity	0.307877519336205	bayes_pls_golite062009
protein binding	0.152745336606766	bayes_pls_golite062009
carbohydrate binding	0.0870260775261698	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [646-696]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFTIIKVPKT VDCLQGILNV IPFQLLSYWL AVKRGHNVDQ PRNLAKSVTV E

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.0
Match:	2pocA
Description:	No description for 2pocA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: