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View Structure Prediction Details

Protein: csn-1
Organism: Caenorhabditis elegans
Length: 601 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for csn-1.

Description E-value Query
Range
Subject
Range
gi|187034889, gi... - gi|39585384|emb|CAE61706.1| Hypothetical protein CBG05655 [Caenorhabditis briggsae], gi|187034889|em...
gi|157766692 - gi|157766692|ref|XP_001675689.1| Hypothetical protein CBG05655 [Caenorhabditis briggsae AF16]
301.0 [0..1] [601..1]

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Predicted Domain #1
Region A:
Residues: [1-80]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNELLDDPM DTGAPAAEAA AADEPLPPAH GIDREVTPKP AGNPDLMQQS LDNPAIPMHL  60
   61 IEKRDDRRES CDDGYSLTVN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [81-184]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESAIDIESLA CSYDSNAFFL RARFIARHCP ILRADAYISL INYLKEHTTD ITHYVAFFNE  60
   61 LESELARKEF KNRQLNFQIP LRDQKWIEEN GATWQSTTDQ LQAE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [185-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YKRHKDEGVK ESTRRAMEDL FQHYMMAGKI DEAIRLYSRG IRDYCTQLKH SINMWINWME  60
   61 VAICANDWGK LDTVTNTAYR SLKDADDAEK NSQQSQQAPP QRGENAPYMV ERDPNAPIQT 120
  121 LTNRQLIETA LAKCLAAQVL LKLRNKRYSQ VVETILQIKT ECLQSKWFV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.154902
Match: 2fo7A
Description: Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [354-446]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSSDLGIYGM LSAMATMSRA DLKLQVSGNG TFRKLLESEP QLIELLGSYT SSRFGRCFEI  60
   61 MRSVKPRLLL DPFISRNVDE LFEKIRQKCV LQY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [447-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQPYSTIKMA TMAEAVGMSS AELQLSLLEL IEQKHVSLKI DQNEGIVRIL DERDENAILK  60
   61 RVNVTCDRAT QKAKSLLWKT TLAGANIHSI SD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.0
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.29569167054278 bayes_pls_golite062009
DNA binding 4.90756541371868 bayes_pls_golite062009
nucleic acid binding 4.69183445184264 bayes_pls_golite062009
transcription factor activity 4.14166958134441 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
sequence-specific DNA binding 2.48053910222825 bayes_pls_golite062009
transcription activator activity 2.29614125067822 bayes_pls_golite062009
transcription repressor activity 2.19033875364989 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.48055533524841 bayes_pls_golite062009
structure-specific DNA binding 1.33374581364046 bayes_pls_golite062009
small conjugating protein ligase activity 1.27763700765562 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.12147035668008 bayes_pls_golite062009
transcription factor binding 0.83705247708153 bayes_pls_golite062009
acid-amino acid ligase activity 0.754042916649094 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.657984195080457 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.486434906547244 bayes_pls_golite062009
double-stranded DNA binding 0.286130392009263 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
transferase activity 0.064832527337659 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [539-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KETRPKRKNQ KESAKFDRNF GGIDVDEDPR GIAGPSGLSD DFNIAYDQQP QQQVQYLEDL  60
   61 GDI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle