YRC Public Data Repository - Protein Structure Prediction

Protein:	CE08444
Organism:	Caenorhabditis elegans
Length:	191 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE08444.

Description	E-value	Query Range	Subject Range
KAD_METMA - Adenylate kinase OS=Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / ... KAD_METMA - Adenylate kinase OS=Methanosarcina mazei GN=adk PE=3 SV=1	167.0	[0..4]	[187..2]
KAD_METBF - Adenylate kinase OS=Methanosarcina barkeri (strain Fusaro / DSM 804) GN=adk PE=3 SV=1	167.0	[0..4]	[187..2]
KAD_CARHZ - Adenylate kinase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) GN=a...	166.0	[0..1]	[187..1]
gi\|169347079, gi... - gi\|169347079\|ref\|ZP_02866021.1\| adenylate kinase [Clostridium perfringens C str. JGS1495], gi\|169296... gi\|182626945, gi... - gi\|182626945\|ref\|ZP_02954678.1\| adenylate kinase [Clostridium perfringens D str. JGS1721], gi\|177907... KAD_CLOP1 - Adenylate kinase OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / N... gi\|170663256, gi... - gi\|170663256\|gb\|EDT15939.1\| adenylate kinase [Clostridium perfringens E str. JGS1987], gi\|168205213\|... KAD_CLOPS - Adenylate kinase OS=Clostridium perfringens (strain SM101 / Type A) GN=adk PE=3 SV=1 gi\|168211884, gi... - gi\|170710173\|gb\|EDT22355.1\| adenylate kinase [Clostridium perfringens B str. ATCC 3626], gi\|16821188... gi\|168215197, gi... - gi\|170713401\|gb\|EDT25583.1\| adenylate kinase [Clostridium perfringens CPE str. F4969], gi\|168215197\|... gi\|168216652, gi... - gi\|182381130\|gb\|EDT78609.1\| adenylate kinase [Clostridium perfringens NCTC 8239], gi\|168216652\|ref\|Z...	164.0	[0..1]	[187..1]
KAD_METAC - Adenylate kinase OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) GN=a... KAD_METAC - Adenylate kinase OS=Methanosarcina acetivorans GN=adk PE=3 SV=1	164.0	[0..4]	[187..2]
KAD_METTP - Adenylate kinase OS=Methanosaeta thermophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) GN=adk...	164.0	[0..4]	[187..2]
KAD_STRAW - Adenylate kinase OS=Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 ... KAD_STRAW - Adenylate kinase OS=Streptomyces avermitilis GN=adk PE=3 SV=1	163.0	[0..4]	[188..2]
gi\|54288772 - gi\|54288772\|gb\|AAV31762.1\| adenylate kinase [Geobacillus stearothermophilus]	163.0	[0..4]	[185..2]
gi\|2924292 - gi\|2924292\|emb\|CAA58138.1\| AdK adenylate kinase [Streptomyces coelicolor A3(2)]	163.0	[0..4]	[184..2]

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Predicted Domain #1

Region A:
Residues: [1-191]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYNVVFVLGP PGSGKGTICT QIHENLGYVH LSAGDLLRAE RERAGSEYGA LIEGHIKNGS  60
   61 IVPVEITCAL LENAMIASKD ANGFLIDGFP RNEDNWSGWN KQMGGKVNEQ FVLFLSCPVD 120
  121 VCIDRCLHRG QGRTDDNVES LKKRVETYNQ STFPIIEHFE KVGMVREVNS ERPVTEVYED 180
  181 VVKVFAAANQ K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.69897
Match:	1tevA
Description:	Crystal structure of the human UMP/CMP kinase in open conformation
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	5.63633783771436	bayes_pls_golite062009
nucleotide kinase activity	4.87013305162694	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	4.71956130169341	bayes_pls_golite062009
adenylate kinase activity	3.67594732794865	bayes_pls_golite062009
transporter activity	3.06347241703095	bayes_pls_golite062009
transmembrane transporter activity	2.92178249124988	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.72471277217637	bayes_pls_golite062009
pyrophosphatase activity	2.65178178494722	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.6324074638534	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.62930532133361	bayes_pls_golite062009
active transmembrane transporter activity	2.47371672314006	bayes_pls_golite062009
primary active transmembrane transporter activity	2.36656376979386	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.36628513972722	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.33101326378731	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.32956222649229	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.32729839766053	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	2.29455092461489	bayes_pls_golite062009
ATPase activity	2.23432662573776	bayes_pls_golite062009
ATPase activity, coupled	2.22021172695288	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
DNA binding	1.7904783386531	bayes_pls_golite062009
transcription regulator activity	1.68903321260301	bayes_pls_golite062009
substrate-specific transporter activity	1.62497652645669	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.39044805677656	bayes_pls_golite062009
hydrolase activity	1.32740066346416	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.28936854749141	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.27520023113176	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
guanylate kinase activity	0.98934362137863	bayes_pls_golite062009
purine nucleotide binding	0.912853112793192	bayes_pls_golite062009
nucleotide binding	0.905342574142397	bayes_pls_golite062009
purine ribonucleotide binding	0.904115761720541	bayes_pls_golite062009
ribonucleotide binding	0.904053997411779	bayes_pls_golite062009
GTPase activity	0.83849854735032	bayes_pls_golite062009
structural constituent of ribosome	0.738234102557832	bayes_pls_golite062009
protein transporter activity	0.712797684532763	bayes_pls_golite062009
motor activity	0.70874549510465	bayes_pls_golite062009
ion transmembrane transporter activity	0.678463776360409	bayes_pls_golite062009
transcription factor activity	0.603758349693077	bayes_pls_golite062009
CTP synthase activity	0.554689818807922	bayes_pls_golite062009
microtubule motor activity	0.48522137429998	bayes_pls_golite062009
ATP binding	0.38929752840764	bayes_pls_golite062009
adenyl ribonucleotide binding	0.364108656344062	bayes_pls_golite062009
adenyl nucleotide binding	0.356069365520539	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
cation transmembrane transporter activity	0.256834704602307	bayes_pls_golite062009
formate-tetrahydrofolate ligase activity	0.21533099279384	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
structural molecule activity	0.0558641287316701	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: