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View Structure Prediction Details

Protein: ech-4
Organism: Caenorhabditis elegans
Length: 385 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ech-4.

Description E-value Query
Range
Subject
Range
gi|18312600, gi|... - gi|18312600|ref|NP_559267.1| 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase [Pyrobaculum ae...
318.0 [0..25] [385..307]

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Predicted Domain #1
Region A:
Residues: [1-109]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRNLTLAAR SVLYNPQVSV RSFSAQADFE KAQKNLKTLK EEPDNDVKLQ LYGLFKQATA  60
   61 GDVQGKRPGM MDFVGRAKYD AWNTLKGQTQ DEARANYAKL VGGLISEEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.69897
Match: 2cquA
Description: Solution Structure of RSGI RUH-045, a Human Acyl-CoA Binding Protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [110-385]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAAPEPTGPS IEGLENVDGL SVTREGKVFK IALNRPKKFN ALTLEMYQGI QKALEVSNND  60
   61 KSTSITVITA NGSYYCAGND LTNFKAAAGG TKEQIADMAN TAKVIMKDYV NAYINHEKPL 120
  121 IALINGPAVG IAVTVLGMFD YVIATDKASF HTPFAPLGQS PEGVSSYTFP LIMGSLRASE 180
  181 MLLVCKKISA QTAKDYGLVN EVVPDAEFQS HAQKTVEAFS QLPPETLRIN KKLLRSLHKE 240
  241 KLLEVNNIEA DQICERWQSK ECHQAIAAFM TKGAKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.69897
Match: 2f6qA
Description: The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3-hydroxyacyl-CoA dehydrogenase activity 4.25084649365698 bayes_pls_golite062009
enoyl-CoA hydratase activity 3.92947460544831 bayes_pls_golite062009
CoA carboxylase activity 3.59076614105466 bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds 3.4980371783229 bayes_pls_golite062009
acetyl-CoA carboxylase activity 3.34692152434862 bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing C=C bonds 1.97586838275054 bayes_pls_golite062009
dodecenoyl-CoA delta-isomerase activity 1.80820904754223 bayes_pls_golite062009
peptidase activity 1.47343502162051 bayes_pls_golite062009
catalytic activity 1.46154163027498 bayes_pls_golite062009
3-hydroxybutyryl-CoA epimerase activity 1.31614278936637 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.23984584411791 bayes_pls_golite062009
propionyl-CoA carboxylase activity 1.20853698666984 bayes_pls_golite062009
binding 1.20603792135994 bayes_pls_golite062009
nucleic acid binding 1.15490979946714 bayes_pls_golite062009
acyl-CoA binding 1.11251823193438 bayes_pls_golite062009
racemase and epimerase activity, acting on hydroxy acids and derivatives 1.08284170936757 bayes_pls_golite062009
long-chain-3-hydroxyacyl-CoA dehydrogenase activity 1.03484393216342 bayes_pls_golite062009
ligase activity 0.98581896521131 bayes_pls_golite062009
endopeptidase activity 0.875283244957267 bayes_pls_golite062009
long-chain-enoyl-CoA hydratase activity 0.571617594666499 bayes_pls_golite062009
serine hydrolase activity 0.33742439899675 bayes_pls_golite062009
serine-type peptidase activity 0.317691759858941 bayes_pls_golite062009
serine-type endopeptidase activity 0.231579308140546 bayes_pls_golite062009
hydrolase activity 0.167287221009063 bayes_pls_golite062009

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