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View Structure Prediction Details

Protein: eme1
Organism: Schizosaccharomyces pombe
Length: 738 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eme1.

Description E-value Query
Range
Subject
Range
gi|164424609, gi... - gi|164424609|ref|XP_963667.2| hypothetical protein NCU06826 [Neurospora crassa OR74A], gi|157070586|...
gi|18375979 - gi|18375979|emb|CAD21209.1| conserved hypothetical protein [Neurospora crassa]
484.0 [0..38] [735..26]
gi|32413264, gi|... - gi|32413264|ref|XP_327112.1| hypothetical protein ( hypothetical protein B14D6.80 [imported] - Neuro...
gi|85110858 - gi|85110858|ref|XP_963667.1| hypothetical protein
479.0 [0..38] [735..50]
gi|42544993, gi|... - gi|46109618|ref|XP_381867.1| hypothetical protein FG01691.1 [Gibberella zeae PH-1], gi|42544993|gb|E...
456.0 [0..88] [720..66]
gi|38108427, gi|... - gi|39968671|ref|XP_365726.1| hypothetical protein MGG_02428 [Magnaporthe grisea 70-15], gb|EAA54443....
454.0 [0..52] [735..23]
gi|67541416, gi|... - gi|67541416|ref|XP_664482.1| hypothetical protein AN6878.2 [Aspergillus nidulans FGSC A4], ref|XP_41...
454.0 [0..115] [714..3]
EME1_MOUSE - Crossover junction endonuclease EME1 OS=Mus musculus GN=Eme1 PE=1 SV=1
371.0 [0..210] [725..18]
MMS4 - Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in r...
MMS4_YEAST - Crossover junction endonuclease MMS4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MMS...
369.0 [0..92] [734..6]
gi|109488819, gi... - gi|164663911|ref|NP_001099300.2| essential meiotic endonuclease 1 homolog 1 [Rattus norvegicus], gi|...
367.0 [0..210] [725..18]
gi|88176318, gi|... - gi|88176318|gb|EAQ83786.1| hypothetical protein CHGG_10190 [Chaetomium globosum CBS 148.51], gi|1162...
356.0 [0..49] [735..2]
gi|119175906, gi... - gi|90298890|gb|EAS28521.1| hypothetical protein CIMG_09725 [Coccidioides immitis RS], gi|119175906|r...
351.0 [0..176] [735..601]

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Predicted Domain #1
Region A:
Residues: [1-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLQSTDSAI VIDSEADVDI SSSQASPSKV CRDNIALSEH NVITVLDTPQ RSTQCDSLLK  60
   61 SFSTPLVSGS EDVLPSPRDA LNITNKKSVT DNLLLSLTSS NQSTNTNLNP SSRVEIINLN 120
  121 SSPPNSLSSQ PKHQEFHLFH TPTIPRTTQL SSKTS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [156-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPIVIPDDNE QVASPLSKKA ASLTSSPLKD FQSSPPLSTV LQKSHSLHDI LLDTNDDDHF  60
   61 PFTQSPLTKT KSFNDALTSS SSILKPCMPS IASPTSNRLS HAPSTPNLFP NQDSSNTIDL 120
  121 INNRSKTSVE NQERTFNLTS DVHLDSPTSP SKHSSIEPNT SQEDSFQELP SLNKLSIQSR 180
  181 AFKKMRLPKI SRTTDTPPAS TSNSNKKNLD KLKKMRK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [373-439]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LCSRSLEPYE LDSNTQRKRK RYEDSLKKSK TLDKVDSLNR KMAKELDRKN SKELQKINKV  60
   61 KRTKEEC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [440-738]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSEIILLSPD DWASSWYSTV RSQLDSYNCQ FVVNSNQPKD SIMWKRKVNN VFNSSTNRFE  60
   61 LSIEHEQIEP FALLRLKCRD FIKYIEEDQA DTFFHEMSEK FKGCKLILLL EGIPNYFKSL 120
  121 KAELNRQYAA AVNSGTRPLL FGSLSKYQNF TKEKLESEIV RFSFEHSILI NTSNDEKETA 180
  181 QWIVSFTGDI ALSRYKHFSK FSARASTTEI GHVKSADRIE NSLNFMLRQI LRVTPNIANA 240
  241 ICDQFDSIPS LIHHLKTHGE ESLTNVVIQS SISERNLGPV LSRRIYNTFL CKEASSDAP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.22
Match: 2bgwA
Description: XPF from Aeropyrum pernix, complex with DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
four-way junction helicase activity 9.97778352333441 bayes_pls_golite062009
DNA helicase activity 7.39534793109438 bayes_pls_golite062009
endodeoxyribonuclease activity 3.3215200974849 bayes_pls_golite062009
single-stranded DNA specific endodeoxyribonuclease activity 3.18118446093396 bayes_pls_golite062009
deoxyribonuclease activity 3.15144163151183 bayes_pls_golite062009
excinuclease ABC activity 2.93145997831744 bayes_pls_golite062009
structure-specific DNA binding 2.54099670773663 bayes_pls_golite062009
single-stranded DNA binding 2.43123013915603 bayes_pls_golite062009
binding 2.15665005558542 bayes_pls_golite062009
nucleic acid binding 1.99056241947033 bayes_pls_golite062009
helicase activity 1.95147423101621 bayes_pls_golite062009
damaged DNA binding 1.93355995630071 bayes_pls_golite062009
DNA binding 1.8937816608663 bayes_pls_golite062009
nuclease activity 1.53464565125134 bayes_pls_golite062009
endonuclease activity 1.2384221353329 bayes_pls_golite062009
pyrophosphatase activity 0.868370062080145 bayes_pls_golite062009
catalytic activity 0.776505703815067 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.757551245363434 bayes_pls_golite062009
protein binding 0.687937183662529 bayes_pls_golite062009
double-stranded DNA binding 0.593379763919056 bayes_pls_golite062009
DNA strand annealing activity 0.591712648797139 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle