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View Structure Prediction Details

Protein: SPCC645.13
Organism: Schizosaccharomyces pombe
Length: 721 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC645.13.

Description E-value Query
Range
Subject
Range
gi|20521870 - gi|20521870|dbj|BAA13438.2| KIAA0244 [Homo sapiens]
342.0 [0..2] [664..702]
gi|73973196 - gi|73973196|ref|XP_538985.2| PREDICTED: similar to PHD finger protein 3 isoform 1 [Canis familiaris]
329.0 [0..2] [664..697]
gi|187953739, gi... - gi|94364894|ref|XP_979315.1| PREDICTED: similar to PHD finger protein 3 isoform 9 [Mus musculus], gi...
324.0 [0..2] [663..675]

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Predicted Domain #1
Region A:
Residues: [1-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVRKSTRRTA KASEKPPETV VRCVCKSQED IGDTWVQCDG CDCWQHASCV GLADKDIPES  60
   61 YYCEVCHSRS DVSSQVQNSP N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 2f6jA
Description: No description for 2f6jA was found.

Predicted Domain #2
Region A:
Residues: [82-178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDEEHQTADL LASNEGNEKN NEENNVVSSD SKEAITKESG AELESSEPAS TNSNVGMTTR  60
   61 SGRQSPRTPI GSTTPKSSHS PPSTRKRRGS VGTTATH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [179-360]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKRSKNAPKT SPKDASNETA DQEKELSLHT SIDEIQNPVR KSVAKAWVSV FEKIIEKAKL  60
   61 EGVQGLEDLN STSLALQLEH IMFMVLSYTT DHSLTPNNKY REKFRALRFN LVDDKNPAFR 120
  121 ARVLKNEISF NDLVNLSSEE MANPDLKNLA EEIRQQSTEN TVIKQHLIAP RDRLLDEDKL 180
  181 TQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.154902
Match: 2dmeA
Description: No description for 2dmeA was found.

Predicted Domain #4
Region A:
Residues: [361-447]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDELGIAEND DAMFPKPPGE LVAPISIAEE EPTIDSKSPT LPEHNPLSED DTSNGDKAAK  60
   61 RKGSFNDTKP IVNVPSIVEI DDPTILD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [448-645]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVEEEPLARN DSFSSPYSPA EDMAEESEFF GMKEKIWTGK VKMATVSEFH ANALNLFGDV  60
   61 SASHLFEILS ATALIEGRIS VSSVLQYFHA LRKTPSKEII AVLFVPTEQN SQGFDILYDY 120
  121 FVKRNRYGVL HSKSNSVKDA YIIPMPSGNS VPELLDLLPK VDLPKDRNFQ YFMGLFVLNK 180
  181 SSSRHESVER ATPITTST

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.42
Match: 1ow1A
Description: Crystal structure of the SPOC domain of the human transcriptional corepressor, SHARP.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 3.54473441396096 bayes_pls_golite062009
nucleic acid binding 3.48558304847931 bayes_pls_golite062009
transcription regulator activity 2.99210735079034 bayes_pls_golite062009
binding 2.41724497205118 bayes_pls_golite062009
sequence-specific DNA binding 2.05998863112202 bayes_pls_golite062009
promoter binding 1.83726450182234 bayes_pls_golite062009
transcription repressor activity 1.4747942371973 bayes_pls_golite062009
transcription activator activity 1.38544336130022 bayes_pls_golite062009
transcription factor activity 1.36469181687855 bayes_pls_golite062009
structure-specific DNA binding 1.10125855381509 bayes_pls_golite062009
protein binding 1.08484616730639 bayes_pls_golite062009
DNA-dependent ATPase activity 0.761344747515317 bayes_pls_golite062009
double-stranded DNA binding 0.72942170277234 bayes_pls_golite062009
DNA helicase activity 0.486136971288514 bayes_pls_golite062009
transcription corepressor activity 0.468110073157235 bayes_pls_golite062009
helicase activity 0.409609667937952 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.364602306790165 bayes_pls_golite062009
telomeric DNA binding 0.323407552453846 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.311579649994958 bayes_pls_golite062009
ATP-dependent helicase activity 0.311579649994958 bayes_pls_golite062009
catalytic activity 0.284946544609129 bayes_pls_golite062009
transcription factor binding 0.147270026435341 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [646-721]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGIPSTYQSA SGTPTNPVHS YPSLESIINA LTPSDMLLIK DVVENNPQIR ANPSLAINPQ  60
   61 FMQNAISAAQ KKASKQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle