YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC1773.06c
Organism:	Schizosaccharomyces pombe
Length:	346 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC1773.06c.

Description	E-value	Query Range	Subject Range
gi\|40795502 - gi\|40795502\|gb\|AAR91477.1\| thermostable alcohol dehydrogenase [Geobacillus sp. M10EXG]	341.0	[0..3]	[346..1]
ADH3_GEOSE - Alcohol dehydrogenase OS=Geobacillus stearothermophilus PE=1 SV=1	338.0	[0..3]	[346..1]
gi\|56419266, gi\|... - gi\|56419266\|ref\|YP_146584.1\| alcohol dehydrogenase [Geobacillus kaustophilus HTA426], gi\|56379108\|db...	329.0	[0..3]	[345..1]
gi\|56961828, gi\|... - gi\|56961828\|ref\|YP_173550.1\| alcohol dehydrogenase [Bacillus clausii KSM-K16], gi\|56908062\|dbj\|BAD62...	326.0	[0..3]	[346..10]
gi\|148559159, gi... - gi\|148559159\|ref\|YP_001258230.1\| alcohol dehydrogenase, zinc-containing [Brucella ovis ATCC 25840], ... gi\|161618188, gi... - gi\|161618188\|ref\|YP_001592075.1\| alcohol dehydrogenase [Brucella canis ATCC 23365], gi\|161334999\|gb\|... gi\|163842470, gi... - gi\|163842470\|ref\|YP_001626874.1\| alcohol dehydrogenase [Brucella suis ATCC 23445], gi\|163673193\|gb\|A... gi\|189019022, gi... - gi\|189023450\|ref\|YP_001934218.1\| Zinc-containing alcohol dehydrogenase [Brucella abortus S19], gi\|18... gi\|82699116 - gi\|82699116\|ref\|YP_413690.1\| zinc-containing alcohol dehydrogenase [Brucella melitensis biovar Abort... gi\|62289176, gi\|... - gi\|62289176\|ref\|YP_220969.1\| alcohol dehydrogenase, zinc-containing [Brucella abortus bv. 1 str. 9-9... gi\|82615217 - gi\|82615217\|emb\|CAJ10160.1\| Zinc-containing alcohol dehydrogenase superfamily:Zinc-containing alcoho... gi\|23346983, gi\|... - gi\|23501112\|ref\|NP_697239.1\| alcohol dehydrogenase, zinc-containing [Brucella suis 1330], gi\|2334698... gi\|225851734, gi... - gi\|225851734\|ref\|YP_002731967.1\| Alcohol dehydrogenase [Brucella melitensis ATCC 23457], gi\|22564009... gi\|254696625 - gi\|254696625\|ref\|ZP_05158453.1\| Alcohol dehydrogenase [Brucella abortus bv. 2 str. 86/8/59] gi\|254701004 - gi\|254701004\|ref\|ZP_05162832.1\| Alcohol dehydrogenase [Brucella suis bv. 5 str. 513] gi\|254690501 - gi\|254690501\|ref\|ZP_05153755.1\| Alcohol dehydrogenase [Brucella abortus bv. 6 str. 870] gi\|254694991 - gi\|254694991\|ref\|ZP_05156819.1\| Alcohol dehydrogenase [Brucella abortus bv. 3 str. Tulya] gi\|254709348 - gi\|254709348\|ref\|ZP_05171159.1\| Alcohol dehydrogenase [Brucella pinnipedialis B2/94] gi\|254713230 - gi\|254713230\|ref\|ZP_05175041.1\| Alcohol dehydrogenase [Brucella ceti M644/93/1] gi\|254705379 - gi\|254705379\|ref\|ZP_05167207.1\| Alcohol dehydrogenase [Brucella suis bv. 3 str. 686] gi\|254707110 - gi\|254707110\|ref\|ZP_05168938.1\| Alcohol dehydrogenase [Brucella pinnipedialis M163/99/10] gi\|254731535 - gi\|254731535\|ref\|ZP_05190113.1\| Alcohol dehydrogenase [Brucella abortus bv. 4 str. 292] gi\|254716416 - gi\|254716416\|ref\|ZP_05178227.1\| Alcohol dehydrogenase [Brucella ceti M13/05/1] gi\|254718415 - gi\|254718415\|ref\|ZP_05180226.1\| Alcohol dehydrogenase [Brucella sp. 83/13]	322.0	[0..3]	[345..5]
gi\|222055606, gi... - gi\|222055606\|ref\|YP_002537968.1\| Alcohol dehydrogenase zinc-binding domain protein [Geobacter sp. FR...	322.0	[0..3]	[345..6]
gi\|25282993 - pir\|\|AD3470 alcohol dehydrogenase (EC 1.1.1.1) [imported] - Brucella melitensis (strain 16M) gi\|17988029, gi\|... - gi\|17988029\|ref\|NP_540663.1\| alcohol dehydrogenase [Brucella melitensis 16M], gi\|17983775\|gb\|AAL5292...	320.0	[0..3]	[345..37]
gi\|46196027, gi\|... - gi\|46198405\|ref\|YP_004072.1\| alcohol dehydrogenase [Thermus thermophilus HB27], gi\|46196027\|gb\|AAS80...	318.0	[0..3]	[345..1]

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Predicted Domain #1

Region A:
Residues: [1-346]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALRYVVHDE ISGFDQLKPE EYEVPQKLNP GEVLVKLKAA SLNYRDLIIT KGLYPLPLQL  60
   61 PVVPGSDGAG IIEKVGEDVE GFEKGDSVVC NFFTNYLDGT PTDFATHSAL GGTRDGCFQK 120
  121 YAVLPAHALV HAPKNLSFEE IATLPCAAVT AWNGLFGSKE HQVKPGNNVL VLGTGGVSTF 180
  181 ALQFALAAGA NVTVTSSSDE KLEFAKKLGA THTINYKKTP QWASPALKMT NGVGYHHVIE 240
  241 VGGEKTLPQS IACLAKDGMI SMIGFVASEG TTPNLTSIIG QILNRNANIR GIFVGSVSMF 300
  301 RDMVACIEAK DIHPVVDKVF PFDQLKEAYE YQWSQAHIGK VVLKID

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	93.0
Match:	1rjwA
Description:	CRYSTAL STRUCTURE OF NAD(+)-DEPENDENT ALCOHOL DEHYDROGENASE FROM BACILLUS STEAROTHERMOPHILUS STRAIN LLD-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ethanol binding	3.52197234018599	bayes_pls_golite062009
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
methylglyoxal reductase (NADH-dependent) activity	3.00190838171391	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	2.94416173750168	bayes_pls_golite062009
retinol binding	2.90377414635828	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	2.26153457113968	bayes_pls_golite062009
NADPH:quinone reductase activity	2.16668841986245	bayes_pls_golite062009
alcohol binding	2.01620480773869	bayes_pls_golite062009
all-trans retinal binding	1.96535395605564	bayes_pls_golite062009
benzaldehyde dehydrogenase activity	1.81250968237368	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
DNA binding	1.61355789916908	bayes_pls_golite062009
transcription regulator activity	1.55390653047158	bayes_pls_golite062009
nucleic acid binding	1.48478425318425	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	1.22416351603098	bayes_pls_golite062009
chaperone binding	1.19079350615542	bayes_pls_golite062009
retinol dehydrogenase activity	1.16811519855038	bayes_pls_golite062009
binding	0.982999356179965	bayes_pls_golite062009
transcription factor activity	0.91090893050278	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.905392379451071	bayes_pls_golite062009
transporter activity	0.793769336118517	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.788034697021177	bayes_pls_golite062009
structural molecule activity	0.75267483298133	bayes_pls_golite062009
transmembrane transporter activity	0.635891484075352	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.62461633437589	bayes_pls_golite062009
substrate-specific transporter activity	0.555188550031886	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.51503848775098	bayes_pls_golite062009
protein binding	0.507836099271263	bayes_pls_golite062009
NAD or NADH binding	0.44922383360529	bayes_pls_golite062009
molecular transducer activity	0.435382281024944	bayes_pls_golite062009
signal transducer activity	0.435382281024944	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.410307505174239	bayes_pls_golite062009
coenzyme binding	0.35922330382799	bayes_pls_golite062009
ion transmembrane transporter activity	0.29802814097478	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.261132005311306	bayes_pls_golite062009
active transmembrane transporter activity	0.239024094835991	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	0.233238483713519	bayes_pls_golite062009
receptor activity	0.219998435023684	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.216422278300306	bayes_pls_golite062009
cation transmembrane transporter activity	0.212092278332619	bayes_pls_golite062009
metal ion transmembrane transporter activity	0.178823255212317	bayes_pls_golite062009
G-protein coupled receptor activity	0.135469305070471	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.124826575912808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.118312276550651	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.113340150368917	bayes_pls_golite062009
fatty acid synthase activity	0.0962368786590111	bayes_pls_golite062009
pyrophosphatase activity	0.0696058100530442	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0591634687578807	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0560606007580392	bayes_pls_golite062009
transmembrane receptor activity	0.0180992866169776	bayes_pls_golite062009
gated channel activity	0.015794644474568	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: