YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC1223.07c
Organism:	Schizosaccharomyces pombe
Length:	580 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC1223.07c.

Description	E-value	Query Range	Subject Range
gi\|49649012 - gi\|49649012\|emb\|CAG81342.1\| YALI0D22264p [Yarrowia lipolytica] gi\|50551341, gi\|... - gi\|50551341\|ref\|XP_503144.1\| YALI0D22264p [Yarrowia lipolytica], gi\|49649012\|emb\|CAG81342.1\| unnamed...	502.0	[0..1]	[580..1]
gi\|50286523, gi\|... - gi\|50286523\|ref\|XP_445690.1\| unnamed protein product [Candida glabrata], gi\|49524995\|emb\|CAG58601.1\|... gi\|49524995 - gi\|49524995\|emb\|CAG58601.1\| unnamed protein product [Candida glabrata]	494.0	[0..1]	[580..1]
gi\|207343237 - gi\|207343237\|gb\|EDZ70762.1\| YLL018Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|151941152 - gi\|151941152\|gb\|EDN59530.1\| aspartyl-tRNA synthetase [Saccharomyces cerevisiae YJM789] DPS1 - Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspa... gi\|190406028 - gi\|190406028\|gb\|EDV09295.1\| aspartyl-tRNA synthetase [Saccharomyces cerevisiae RM11-1a] SYDC_YEAST - Aspartate--tRNA ligase, cytoplasmic OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DPS1...	481.0	[0..1]	[580..1]
gi\|77974514, gi\|... - gi\|77974514\|ref\|ZP_00830054.1\| COG1190: Lysyl-tRNA synthetase (class II) [Yersinia frederiksenii ATC...	473.0	[0..39]	[575..5]
gi\|49642370 - gi\|49642370\|emb\|CAH00332.1\| KLLA0D03839p [Kluyveromyces lactis] gi\|50306525, gi\|... - gi\|50306525\|ref\|XP_453236.1\| unnamed protein product [Kluyveromyces lactis], gi\|49642370\|emb\|CAH0033...	473.0	[0..4]	[580..1]
SYK_BACSK - Lysine--tRNA ligase OS=Bacillus clausii (strain KSM-K16) GN=lysS PE=3 SV=1	469.0	[0..42]	[577..3]
gi\|66523683 - gi\|66523683\|ref\|XP_393437.2\| PREDICTED: similar to Aspartyl-tRNA synthetase CG3821-PA [Apis mellifer...	469.0	[0..30]	[580..14]
gi\|39590828, gi\|... - gi\|39590828\|emb\|CAE65201.1\| Hypothetical protein CBG10076 [Caenorhabditis briggsae], gi\|187031522\|em... gi\|157774527 - gi\|157774527\|ref\|XP_001665329.1\| hypothetical protein CBG10076 [Caenorhabditis briggsae AF16]	468.0	[0..20]	[580..1]
gi\|77963232, gi\|... - gi\|77963232\|ref\|ZP_00827044.1\| COG1190: Lysyl-tRNA synthetase (class II) [Yersinia mollaretii ATCC 4...	467.0	[0..39]	[575..5]
drs-1 - Aspartyl-tRNA synthetase status:Confirmed UniProt:Q03577 protein_id:CAA79536.1	467.0	[0..20]	[580..1]

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Predicted Domain #1

Region A:
Residues: [1-580]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEMEKQVEN LSLEAKNEKP KEVILGEDGK PLSKKALKKL EKEREKEQKR KEREAREAEE  60
   61 KKKREANEID YSAGKYGDLP LNRSTARPGR TYTQISDISA KNDGQTVLLR ARVYTSRLQG 120
  121 NKMCFFSLRQ KYDTIQALAV VNKDTISKQM VKWCGSISLE SIVLVEGIVK KSPEIIKSAT 180
  181 VQDAEIHISS IYVISPIKKN LPFLVEDAGR SEEQIRESEE NAAEGDSKFV RVNLDTRLDN 240
  241 RVLDLRTPTN QAIFDIQAGI CQAFREFLLS NSFNEIHTPK MSGASSEGGS NVFKIQYFKT 300
  301 DGFLSQSPQL YKQMLIAADR ERVFEIGPVF RAEDSNTYRH MTEFTGLDLE MAFNEHYHEV 360
  361 MEFIEKLFLY IFKTIREKYA KQVAVVRQQY PSEDFILPDA DRIRFHFKDA VKLLKEAGYR 420
  421 KQLVPGQKVP EDEEFHYCED PEFDDFSTPE ERALGQIVRE KYHTDFYVID KYPSSVRPFY 480
  481 TMPDPEDPRY SNSYDFFMKG QEIMSGAQRI HDPELLVERM KALGVSPDVG LQQYIDAFAI 540
  541 GCPPHAGGGI GLERVVMFYL NLPNIRLASS FPRDPKRLLP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	123.0
Match:	1asyA
Description:	Aspartyl-tRNA synthetase (AspRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
lysine-tRNA ligase activity	11.0047124677093	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	7.89468709683036	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.89468709683036	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.88410036819636	bayes_pls_golite062009
ligase activity	6.92073480193262	bayes_pls_golite062009
asparagine-tRNA ligase activity	5.29805946490109	bayes_pls_golite062009
aspartate-tRNA ligase activity	3.80084837437429	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	3.4145644216516	bayes_pls_golite062009
structural constituent of ribosome	2.90150581291897	bayes_pls_golite062009
glycine-tRNA ligase activity	2.61548498770105	bayes_pls_golite062009
structural molecule activity	2.54582212334303	bayes_pls_golite062009
proline-tRNA ligase activity	2.52223115725965	bayes_pls_golite062009
threonine-tRNA ligase activity	2.18642354927	bayes_pls_golite062009
serine-tRNA ligase activity	2.07594942154162	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
alanine-tRNA ligase activity	1.82594054955281	bayes_pls_golite062009
histidine-tRNA ligase activity	1.72215103383322	bayes_pls_golite062009
transcription regulator activity	1.67362693618722	bayes_pls_golite062009
binding	1.54403712698597	bayes_pls_golite062009
nucleic acid binding	1.48056625237411	bayes_pls_golite062009
DNA binding	1.44496421928708	bayes_pls_golite062009
translation initiation factor activity	1.27539679024898	bayes_pls_golite062009
transcription factor activity	0.825973629967327	bayes_pls_golite062009
sequence-specific DNA binding	0.77755643935497	bayes_pls_golite062009
ribonuclease activity	0.702449673647117	bayes_pls_golite062009
nuclease activity	0.29926900436997	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: