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View Structure Prediction Details

Protein: wis1
Organism: Schizosaccharomyces pombe
Length: 605 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for wis1.

Description E-value Query
Range
Subject
Range
gi|223452 - gi|223452|prf||0806225A genome Y73
275.0 [0..35] [573..258]
YES_CHICK - Tyrosine-protein kinase Yes OS=Gallus gallus GN=YES1 PE=1 SV=3
274.0 [0..57] [592..6]
gi|61504 - gi|61504|emb|CAA24496.1| protein p90gag-yes [Avian sarcoma virus]
gi|61504, gi|9626157 - ref|NP_040506.1| p30 gag-yes protein [Y73 sarcoma virus], gi|61504|emb|CAA24496.1| p90gag-yes protei...
274.0 [0..35] [573..258]
tr|M3W6V8|M3W6V8... - Tyrosine-protein kinase OS=Felis catus GN=SRC PE=3 SV=1
gi|73991940 - gi|73991940|ref|XP_865870.1| PREDICTED: similar to Proto-oncogene tyrosine-protein kinase Src (p60-S...
271.0 [0..56] [592..1]
gi|114615050 - gi|114615050|ref|XP_519269.2| PREDICTED: ephrin receptor EphB4 [Pan troglodytes]
270.0 [0..2] [575..194]
gi|495473 - gi|495473|gb|AAA20598.1| tyrosine kinase
269.0 [0..2] [575..290]
gi|109092120, gi... - gi|109092122|ref|XP_001092301.1| PREDICTED: proto-oncogene tyrosine-protein kinase SRC isoform 2 [Ma...
269.0 [0..56] [592..1]

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Predicted Domain #1
Region A:
Residues: [1-82]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPNNQPLS CSLRQLSISP TAPPGDVGTP GSLLSLSSSS SSNTDSSGSS LGSLSLNSNS  60
   61 SGSDNDSKVS SPSREIPSDP PL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [83-315]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRAVPTVRLG RSTSSRSRNS LNLDMKDPSE KPRRSLPTAA GQNNIGSPPT PPGPFPGGLS  60
   61 TDIQEKLKAF HASRSKSMPE VVNKISSPTT PIVGMGQRGS YPLPNSQLAG RLSNSPVKSP 120
  121 NMPESGLAKS LAAARNPLLN RPTSFNRQTR IRRAPPGKLD LSNSNPTSPV SPSSMASRRG 180
  181 LNIPPTLKQA VSETPFSTFS DILDAKSGTL NFKNKAVLNS EGVNFSSGSS FRI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [316-605]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NMSEIIKLEE LGKGNYGVVY KALHQPTGVT MALKEIRLSL EEATFNQIIM ELDILHKAVS  60
   61 PYIVDFYGAF FVEGSVFICM EYMDAGSMDK LYAGGIKDEG VLARTAYAVV QGLKTLKEEH 120
  121 NIIHRDVKPT NVLVNSNGQV KLCDFGVSGN LVASISKTNI GCQSYMAPER IRVGGPTNGV 180
  181 LTYTVQADVW SLGLTILEMA LGAYPYPPES YTSIFAQLSA ICDGDPPSLP DSFSPEARDF 240
  241 VNKCLNKNPS LRPDYHELAN HPWLLKYQNA DVDMASWAKG ALKEKGEKRS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.522879
Match: 2p55A
Description: No description for 2p55A was found.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
actin binding 1.33479685165255 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
structural constituent of muscle 1.19908793854422 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
structural molecule activity 1.10436308210353 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
transporter activity 0.553953601841147 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
transmembrane transporter activity 0.37676337669549 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
gamma-tubulin binding 0.242410242748222 bayes_pls_golite062009
actin filament binding 0.2403700250846 bayes_pls_golite062009
protein complex binding 0.132247221889251 bayes_pls_golite062009
substrate-specific transporter activity 0.0611721261859464 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle