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View Structure Prediction Details

Protein: smc5
Organism: Schizosaccharomyces pombe
Length: 1065 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for smc5.

Description E-value Query
Range
Subject
Range
gi|73980575 - gi|73980575|ref|XP_532882.2| PREDICTED: similar to SMC6 protein [Canis familiaris]
257.0 [0..3] [1037..553]
gi|109459971 - gi|109459971|ref|XP_215254.4| PREDICTED: similar to SMC5 structural maintenance of chromosomes 5-lik...
232.0 [0..8] [1061..160]
gi|94369992 - gi|94369992|ref|XP_979429.1| PREDICTED: similar to SMC4 structural maintenance of chromosomes 4-like...
226.0 [0..4] [860..205]
gi|114625255 - gi|114625255|ref|XP_520066.2| PREDICTED: SMC5 protein [Pan troglodytes]
222.0 [0..8] [1061..151]
gi|20521095 - gi|20521095|dbj|BAA25520.2| KIAA0594 protein [Homo sapiens]
212.0 [0..8] [1061..67]

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Predicted Domain #1
Region A:
Residues: [1-273]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILTRESYAL GSIVRIKLVN FVTYDYCELF PGPYLNLIIG PNGTGKSTIV SAICIGLGWP  60
   61 PKLLGRAKEA REFIKYGKNT ATIEIEMKYR DDETVTITRQ ISQDKSSSFS INREACATSS 120
  121 ITSLMDTFNV QLNNLCHFLP QDRVAEFAQL DPYSRLMETE RAIDHEGLLP AHEKLIDLRK 180
  181 REREILQNKN QGQSTLNSLK DRQQALEKEV NIFKEREKIK SYIEMLGLAK MLVIYREKTN 240
  241 VFNQLRADKK KLKKDLKDLV EEFQPILDKG EEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.0
Match: 1w1wA
Description: Sc Smc1hd:Scc1-C complex, ATPgS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 3.22518920754305 bayes_pls_golite062009
protein-DNA loading ATPase activity 3.19273435123154 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
motor activity 2.40267948113603 bayes_pls_golite062009
microtubule motor activity 2.37639635793291 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
nucleic acid binding 2.21184938313192 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 1.94055378599526 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
transcription regulator activity 1.83584389083042 bayes_pls_golite062009
bubble DNA binding 1.70168298920956 bayes_pls_golite062009
cytoskeletal protein binding 1.50574672650697 bayes_pls_golite062009
helicase activity 1.16085745407703 bayes_pls_golite062009
tubulin binding 1.01673904002272 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
microtubule binding 0.902404986889887 bayes_pls_golite062009
actin binding 0.875514430441177 bayes_pls_golite062009
structure-specific DNA binding 0.720649395550746 bayes_pls_golite062009
transcription factor activity 0.697256579145077 bayes_pls_golite062009
transcription repressor activity 0.677612020025357 bayes_pls_golite062009
ATP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.59513742813869 bayes_pls_golite062009
double-stranded DNA binding 0.58862275163252 bayes_pls_golite062009
centromeric DNA binding 0.322818640526369 bayes_pls_golite062009
microfilament motor activity 0.26523838851913 bayes_pls_golite062009
four-way junction helicase activity 0.26252931460003 bayes_pls_golite062009
exodeoxyribonuclease V activity 0.185603938981231 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [274-771]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSDLKLKDDT FNDYSSASME LNTSNLRARA SFSNFMENEK KLYEKVNTNR TLLRNANLTL  60
   61 NEAQQSVKSL TERQGPRPSD NGVQDLQEKM QEVNAEKLQH ENEKLESSHE LGSIRTLKAQ 120
  121 KLIDLDNIKR ELSYYNDATK RKLDFMSSAP GWEDAYQTYQ LLKEYESAFE APAYGPIYMN 180
  181 LKCKEKGFAA LIEGFFRTDT FRTFIMSNYN DYLKLMDLIT SKTKYTPTIR EFSSERKKKI 240
  241 EDFEPPCSRE KLQSFGFDGY VIDFLEGPEV VLVALCHMLK IHQIPIAKRE LPPASVNALN 300
  301 NFRLANGDPV LKTYLAGSSI HLVFRSAYGD REITRRTDPL PSRSIYFSEN VEMDLVKRKE 360
  361 EQLNAQLSQL ENLQNEERKL QEKVNEHESL LSRTNDILST LRKERDEKLI PIHEWQQLQE 420
  421 RIEHQTLLLR QREKVPEQFA AEIEKNEDIR KENFEALMNS VLKVKENSIK ATNNFEKMLG 480
  481 SRLNVIEAKY KLEKHEMD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.69
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [772-1065]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANQVNARLTE VQDRLKDITD KLASAREDAM SLYGSVVDSL QTQSSDRQTA ITELNEEFAT  60
   61 SSEVDNKISI EETKLKFMNV NSYVMEQYDA RKKEIEELES KMSDFDQSVE ELQDEMNSIK 120
  121 EDWVSKLEEN VQCISDRFSK GMSGMGYAGE VRLGKSDDYD KWYIDILVQF REEEGLQKLT 180
  181 GQRQSGGERS VSTIMYLLSL QGLAIAPFRI VDEINQGMDP RNERVVHRHI VNSVCDNAVS 240
  241 QYFLVTPKLL PDLTYHRNLK VLCICNGAWL PATFRTSLST YFEKLKKSAL ISSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.045757
Match: 2iw3A
Description: No description for 2iw3A was found.

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