YRC Public Data Repository - Protein Structure Prediction

Protein:	rad25
Organism:	Schizosaccharomyces pombe
Length:	270 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rad25.

Description	E-value	Query Range	Subject Range
gi\|109087133 - gi\|109087133\|ref\|XP_001098275.1\| PREDICTED: similar to tyrosine 3/tryptophan 5 -monooxygenase activa...	436.0	[0..3]	[248..334]
gi\|68436321 - gi\|68436321\|ref\|XP_699659.1\| PREDICTED: similar to tyrosine 3-monooxygenase/tryptophan 5-monooxygena...	433.0	[0..3]	[248..1532]
gi\|17017334 - gi\|17017334\|gb\|AAL33624.1\|AF440230_1 protein kinase A activity reporter 1 fusion protein [synthetic ...	420.0	[0..1]	[256..230]
gi\|114576225 - gi\|114576225\|ref\|XP_525684.2\| PREDICTED: similar to 14.3.3 protein [Pan troglodytes]	415.0	[0..3]	[248..172]
gi\|487918 - gi\|487918\|dbj\|BAA06401.1\| mitochondrial import stimulation factor L subunit [Rattus sp.] 1433E_CHICK - 14-3-3 protein epsilon OS=Gallus gallus GN=YWHAE PE=1 SV=1 gi\|114665586, gi... - gi\|55644755\|ref\|XP_511249.1\| PREDICTED: similar to epsilon isoform of 14-3-3 protein isoform 6 [Pan ... 1433E_RAT - 14-3-3 protein epsilon OS=Rattus norvegicus GN=Ywhae PE=1 SV=1 gi\|55741616 - ref\|NP_001006219.1\| similar to epsilon isoform of 14-3-3 protein [Gallus gallus] 1433E_BOVIN - 14-3-3 protein epsilon OS=Bos taurus GN=YWHAE PE=2 SV=1 1433E_MOUSE - 14-3-3 protein epsilon OS=Mus musculus GN=Ywhae PE=1 SV=1 1433E_SHEEP - 14-3-3 protein epsilon OS=Ovis aries GN=YWHAE PE=1 SV=1 YWHAE - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide gi\|60655097, gi\|... - gi\|61363157\|gb\|AAX42344.1\| tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein ep... gi\|67971280, gi\|... - gi\|90077006\|dbj\|BAE88183.1\| unnamed protein product [Macaca fascicularis], gi\|67971280\|dbj\|BAE01982.... gi\|73967156 - gi\|73967156\|ref\|XP_854358.1\| PREDICTED: similar to 14-3-3 protein epsilon (14-3-3E) (Mitochondrial i... gi\|149724150 - gi\|149724150\|ref\|XP_001504337.1\| PREDICTED: similar to epsilon isoform of 14-3-3 protein [Equus caba...	412.0	[0..4]	[256..3]

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Predicted Domain #1

Region A:
Residues: [1-270]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSRENSVY LAKLAEQAER YEEMVENMKK VACSNDKLSV EERNLLSVAY KNIIGARRAS  60
   61 WRIISSIEQK EESRGNTRQA ALIKEYRKKI EDELSDICHD VLSVLEKHLI PAATTGESKV 120
  121 FYYKMKGDYY RYLAEFTVGE VCKEAADSSL EAYKAASDIA VAELPPTDPM RLGLALNFSV 180
  181 FYYEILDSPE SACHLAKQVF DEAISELDSL SEESYKDSTL IMQLLRDNLT LWTSDAEYNQ 240
  241 SAKEEAPAAA AASENEHPEP KESTTDTVKA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	112.0
Match:	1o9cA
Description:	14-3-3-like protein C
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
tryptophan hydroxylase activator activity	9.05098057244127	bayes_pls_golite062009
protein kinase C inhibitor activity	5.16790132127192	bayes_pls_golite062009
cytoskeletal protein binding	3.42699469191586	bayes_pls_golite062009
actin binding	3.2102277095412	bayes_pls_golite062009
phosphoprotein phosphatase inhibitor activity	3.07610360813748	bayes_pls_golite062009
enzyme inhibitor activity	3.01719375125219	bayes_pls_golite062009
binding	2.865609797812	bayes_pls_golite062009
protein binding	2.70837661160137	bayes_pls_golite062009
phosphatase inhibitor activity	2.64873378059247	bayes_pls_golite062009
steroid hormone receptor binding	2.52034336284118	bayes_pls_golite062009
transcription regulator activity	2.47421036599568	bayes_pls_golite062009
protein serine/threonine kinase inhibitor activity	2.26190206574987	bayes_pls_golite062009
nucleic acid binding	2.24952329412422	bayes_pls_golite062009
protein kinase inhibitor activity	2.1605779239681	bayes_pls_golite062009
kinase inhibitor activity	2.13634503016902	bayes_pls_golite062009
DNA binding	2.12868741280915	bayes_pls_golite062009
enzyme regulator activity	2.06101279275497	bayes_pls_golite062009
receptor binding	1.90211144110648	bayes_pls_golite062009
protein kinase regulator activity	1.89095665930248	bayes_pls_golite062009
kinase regulator activity	1.83999438696779	bayes_pls_golite062009
nuclear hormone receptor binding	1.82791045779247	bayes_pls_golite062009
sequence-specific DNA binding	1.77196747521243	bayes_pls_golite062009
hormone receptor binding	1.75728917995967	bayes_pls_golite062009
transcription repressor activity	1.58823136201189	bayes_pls_golite062009
transcription activator activity	1.55295513057402	bayes_pls_golite062009
enzyme binding	0.97087555033584	bayes_pls_golite062009
transcription factor binding	0.644366120007212	bayes_pls_golite062009
protein domain specific binding	0.549856334651464	bayes_pls_golite062009
transcription corepressor activity	0.493085020732158	bayes_pls_golite062009
catalytic activity	0.260308151913118	bayes_pls_golite062009
glucocorticoid receptor binding	0.201948675373558	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.115610219048892	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: