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View Structure Prediction Details

Protein: orc5
Organism: Schizosaccharomyces pombe
Length: 455 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for orc5.

Description E-value Query
Range
Subject
Range
gi|2739448 - gi|2739448|gb|AAC49897.1| origin recognition complex subunit 5 homolog [Schizosaccharomyces pombe]
301.0 [0..1] [455..1]
ORC5_MOUSE - Origin recognition complex subunit 5 OS=Mus musculus GN=Orc5 PE=2 SV=1
251.0 [0..8] [453..2]
gi|64174879, gi|... - gi|71610986|dbj|BAE16572.1| Origin Recognition Complex subunit 5 [Cricetulus griseus], gi|64174879|g...
249.0 [0..14] [453..8]
CLPB1_SYNEL, CLB... - Chaperone protein clpB 1 OS=Synechococcus elongatus GN=clpB1 PE=3 SV=1, (Q8DJ40) Chaperone clpB 1
CLPB1_THEEB - Chaperone protein ClpB 1 OS=Thermosynechococcus elongatus (strain BP-1) GN=clpB1 PE=3 SV=1
246.0 [0..10] [445..177]
gi|56788790, gi|... - gi|62079099|ref|NP_001014208.1| origin recognition complex, subunit 5-like [Rattus norvegicus], gi|5...
246.0 [0..8] [453..2]
gi|109067761 - gi|109067761|ref|XP_001085300.1| PREDICTED: similar to origin recognition complex subunit 5 isoform ...
244.0 [0..3] [453..109]
gi|85373114, gi|... - gi|85373114|ref|YP_457176.1| ATP-dependent Clp protease [Erythrobacter litoralis HTCC2594], gi|84786...
244.0 [0..10] [445..179]
gi|110833340, gi... - gi|110833340|ref|YP_692199.1| ATP-dependent Clp protease, ATP-binding subunit ClpB [Alcanivorax bork...
244.0 [0..7] [445..173]
gi|98977949, gi|... - gi|98977949|gb|ABF54100.1| ATPase AAA-2 [Sphingopyxis alaskensis RB2256], gi|68537287|ref|ZP_0057706...
244.0 [0..10] [445..179]
gi|78519766, gi|... - gi|78702749|ref|ZP_00867175.1| ATPas [Alkalilimnicola ehrlichei MLHE-1], gi|78519766|gb|EAP33047.1| ...
243.0 [0..10] [445..175]

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Predicted Domain #1
Region A:
Residues: [1-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHLYQLEDEL KKNVFCREDQ IKKLSCLLFN KDCRVPSIVL YGVASTAKTF LLRTAFDLSK  60
   61 EENVWINLQD CFTVAHFWYR ILIKVGVDKD IALKKGINIS GFIYLLEQAM SKRDYHTFLV 120
  121 LDQIDDFAEA STILFSQLAQ LPIVANIPNL SIIFVLHSHP AQYLGTLSIA VIFFPQYTQA 180
  181 EILEICQKTP PNLDFLDRSG DSVFEDEIEL SVWMQYCSFL WSVFGVQCLN DYRSFRSVLD 240
  241 RYWPKFIQPI VEGDIHPADY AQLHKLAKNF LVSDATVTKR LHIINPTEIK NLLDSKSINL 300
  301 SLVSKYLLVS AFLASYNPSR LDAQFFSFSK TSKRRGRKRK QIQDEGVLFS KIPRTAGSKG 360
  361 RSAVKISQLT LGPKPFEVER LIAIYYAISS PVEKVLTADV FVQIATLASL KMILSASKGV 420
  421 LRSLDSPRYI VNVSREYVLK IADSLSFPLD SYLAG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.0
Match: 1qvrA
Description: Crystal Structure Analysis of ClpB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 4.91429252297969 bayes_pls_golite062009
protein-DNA loading ATPase activity 4.80695929076807 bayes_pls_golite062009
motor activity 2.79327761685782 bayes_pls_golite062009
microtubule motor activity 2.74365461017633 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
DNA replication origin binding 1.62491387774159 bayes_pls_golite062009
cytoskeletal protein binding 1.40488517180956 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
tubulin binding 0.979946830272106 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.971476020912368 bayes_pls_golite062009
DNA polymerase activity 0.928091843881235 bayes_pls_golite062009
microtubule binding 0.907162506177187 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
actin binding 0.883285269827407 bayes_pls_golite062009
transcription repressor activity 0.862685397469217 bayes_pls_golite062009
structure-specific DNA binding 0.782430219754236 bayes_pls_golite062009
double-stranded DNA binding 0.6071273686445 bayes_pls_golite062009
histone acetyltransferase activity 0.328186246219424 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.328186246219424 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.268787661420613 bayes_pls_golite062009
RNA helicase activity 0.18426050934025 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
RNA-dependent ATPase activity 0.14606996093053 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.13050483816765 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
microfilament motor activity 0.0313060889304495 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle