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View Structure Prediction Details

Protein: hsf1
Organism: Schizosaccharomyces pombe
Length: 609 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hsf1.

Description E-value Query
Range
Subject
Range
gi|295687 - gi|295687|gb|AAA35313.1| heat shock transcription factor
524.0 [0..1] [609..1]
gi|76625539 - gi|76625539|ref|XP_587710.2| PREDICTED: similar to Heat shock factor protein 2 (HSF 2) (Heat shock t...
416.0 [0..46] [572..68]
gi|109072831 - gi|109072831|ref|XP_001108944.1| PREDICTED: heat shock transcription factor 2 isoform 1 [Macaca mula...
414.0 [0..46] [572..3]
HSF2 - heat shock transcription factor 2
gi|208966442, gi... - gi|208966442|dbj|BAG73235.1| heat shock transcription factor 2 [synthetic construct], gi|167773983|g...
412.0 [0..46] [572..3]
HSF2_MOUSE - Heat shock factor protein 2 OS=Mus musculus GN=Hsf2 PE=2 SV=2
410.0 [0..46] [572..3]
gi|50744518 - gi|50744518|ref|XP_419760.1| PREDICTED: similar to Heat shock factor protein 2 (HSF 2) (Heat shock t...
398.0 [0..47] [572..45]
gi|13928966, gi|... - gi|5764553|gb|AAD51329.1|AF172640_1 heat shock factor 2 [Rattus norvegicus], gi|55778284|gb|AAH86554...
390.0 [0..46] [572..3]

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Predicted Domain #1
Region A:
Residues: [1-156]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIQTASTISS NGGTNQGMES SSANSPEMNG TQNSMSVGMS GSGSSQNRKI TQFSNKLYNM  60
   61 VNDSSTDSLI RWSDRGDSFL VIGHEDFAKL VLPRYFKHNN FSSFVRQLNM YGFHKVPHIQ 120
  121 QGVLQSDSPN ELLEFANPNF QRDQPELLCL VTRKKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.0
Match: 1hksA
Description: SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.77201910025409 bayes_pls_golite062009
binding 3.52874320222492 bayes_pls_golite062009
DNA binding 3.44642410378325 bayes_pls_golite062009
nucleic acid binding 3.25777282180864 bayes_pls_golite062009
transcription factor activity 2.83460075788873 bayes_pls_golite062009
transcription repressor activity 2.39237599101586 bayes_pls_golite062009
sequence-specific DNA binding 1.4788427609721 bayes_pls_golite062009
transcription activator activity 1.28486271107855 bayes_pls_golite062009
protein binding 0.753698599635855 bayes_pls_golite062009
transcription factor binding 0.63938506997853 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.49916895549368 bayes_pls_golite062009
structure-specific DNA binding 0.359916369552683 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [157-295]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSQPVEESNT SLDMSTISSE LQNIRIQQMN LSNELSRIQV DNAALWQENM ENRERQRRHQ  60
   61 ETIDKILRFL ASVYLDGKQK PPSKVMPKSR RLLLEAKYPT VSPTNEPSAH SRPSPQGTTA 120
  121 NSSSASISSL HNTTPDGEG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 9.167491
Match: PF00447.8
Description: No description for PF00447.8 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [296-461]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYRSVQNGRA LNYVSSFNSD SHSPKDYISQ SYTNEPGLKK ESADSFNNSI DSYISPNQSP  60
   61 NTDVPSLNRD DTTDPKVVNT GDIINMLDDA NSIEGSNMNS LSPLLFDYPN SLYPVNNTSS 120
  121 EQHHNSYRGS VSNSQPSGNL SESTNLQPVQ PVDYMSNSNP SYGSYN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [462-609]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEDQLTNFHP GYAMDQKRIS KLSDGITKQD QNIQALADIL GIPLGDGKID DAGFSANSPT  60
   61 NLNLPVSSDL DSVLNIPPNE DVFPDSNPVF DEFTNISNLT SPIEASNGNT FGSNPVSLPN 120
  121 QQKSVNPSLM TVSSPRQVRK KRKSSIGA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle