YRC Public Data Repository - Protein Structure Prediction

Protein:	bip1
Organism:	Schizosaccharomyces pombe
Length:	663 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for bip1.

Description	E-value	Query Range	Subject Range
gi\|94387119 - gi\|94387119\|ref\|XP_994676.1\| PREDICTED: similar to heat shock protein 8 [Mus musculus]	732.0	[0..34]	[642..66]
gi\|67969126 - gi\|67969126\|dbj\|BAE00917.1\| unnamed protein product [Macaca fascicularis]	731.0	[0..34]	[663..5]
HS71L_MACFA - Heat shock 70 kDa protein 1-like OS=Macaca fascicularis GN=HSPA1L PE=2 SV=1 gi\|109070526, gi... - gi\|109070526\|ref\|XP_001113356.1\| PREDICTED: similar to heat shock 70kDa protein 1-like isoform 3 [Ma...	730.0	[0..34]	[663..5]
gi\|34784832 - gi\|34784832\|gb\|AAH56709.1\| Hsp70 protein [Danio rerio]	728.0	[0..31]	[663..2]
gi\|45544523 - gi\|45544523\|dbj\|BAD12572.1\| heat shock protein [Numida meleagris] gi\|50759965 - ref\|XP_429266.1\| PREDICTED: hypothetical protein XP_429266 [Gallus gallus] gi\|118722053, gi... - gi\|118722053\|dbj\|BAF38392.1\| heat shock protein 70kDa [Coturnix japonica], gi\|118197131\|dbj\|BAF37041...	728.0	[0..33]	[643..2]
gi\|111306225, gi... - gi\|118404236\|ref\|NP_001072429.1\| heat shock 70kDa protein 1-like [Xenopus (Silurana) tropicalis], gi...	728.0	[0..33]	[642..3]
gi\|3461866 - gi\|3461866\|dbj\|BAA32521.1\| heat shock protein 70 testis variant [Homo sapiens]	728.0	[0..34]	[663..5]

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Predicted Domain #1

Region A:
Residues: [1-589]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKFQLFSIL SYFVALFLLP MAFASGDDNS TESYGTVIGI DLGTTYSCVA VMKNGRVEII  60
   61 ANDQGNRITP SYVAFTEDER LVGEAAKNQA PSNPENTIFD IKRLIGRKFD EKTMAKDIKS 120
  121 FPFHIVNDKN RPLVEVNVGG KKKKFTPEEI SAMILSKMKQ TAEAYLGKPV THAVVTVPAY 180
  181 FNDAQRQATK DAGTIAGLNV IRIVNEPTAA AIAYGLDKTD TEKHIVVYDL GGGTFDVSLL 240
  241 SIDNGVFEVL ATSGDTHLGG EDFDNRVINY LARTYNRKNN VDVTKDLKAM GKLKREVEKA 300
  301 KRTLSSQKSV RIEIESFFNG QDFSETLSRA KFEEINMDLF KKTLKPVEQV LKDSNLKKSE 360
  361 IDDIVLVGGS TRIPKVQELL ESFFGKKASK GINPDEAVAY GAAVQAGVLS GEEGSDNIVL 420
  421 LDVIPLTLGI ETTGGVMTKL IGRNTPIPTR KSQIFSTAVD NQNTVLIQVY EGERTLTKDN 480
  481 NLLGKFDLRG IPPAPRGVPQ IEVTFEVDAN GVLTVSAVDK SGKGKPEKLV IKNDKGRLSE 540
  541 EDIERMVKEA EEFAEEDKIL KERIEARNTL ENYAYSLKGQ FDDDEQLGG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1yuwA
Description:	crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	7.97191512372019	bayes_pls_golite062009
structural molecule activity	3.59589495899762	bayes_pls_golite062009
structural constituent of cytoskeleton	2.46121037473545	bayes_pls_golite062009
carbohydrate kinase activity	2.33338276303563	bayes_pls_golite062009
cytoskeletal protein binding	2.20983242331685	bayes_pls_golite062009
binding	2.11855816699924	bayes_pls_golite062009
protein binding	2.00711904074672	bayes_pls_golite062009
hydrolase activity	1.88613511243568	bayes_pls_golite062009
hexokinase activity	1.70516840340504	bayes_pls_golite062009
transcription regulator activity	1.68670098354938	bayes_pls_golite062009
nucleic acid binding	1.43834016708999	bayes_pls_golite062009
peptidase activity	1.4127499531612	bayes_pls_golite062009
DNA binding	1.36804228074586	bayes_pls_golite062009
transporter activity	1.2883466875237	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.16749728168925	bayes_pls_golite062009
kinase activity	1.11102445353265	bayes_pls_golite062009
actin binding	1.03829083423378	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.953663805249074	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.900931843471417	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.898645342556399	bayes_pls_golite062009
pyrophosphatase activity	0.875671218597808	bayes_pls_golite062009
substrate-specific transporter activity	0.796517590178929	bayes_pls_golite062009
transcription factor activity	0.783439770973386	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.78242344952806	bayes_pls_golite062009
protein transporter activity	0.780308299678282	bayes_pls_golite062009
ATPase activity	0.687771333492666	bayes_pls_golite062009
myosin binding	0.607451856096	bayes_pls_golite062009
glucose binding	0.53527958884988	bayes_pls_golite062009
glucokinase activity	0.47468456642723	bayes_pls_golite062009
catalytic activity	0.296484721581333	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.186218331473028	bayes_pls_golite062009
chromatin binding	0.155140608043269	bayes_pls_golite062009
protease binding	0.121259015422625	bayes_pls_golite062009
chaperone binding	0.00111313452804307	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [590-663]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVDPEDKQAV LDAVEDVAEW LEIHGEDASK EEFEDQRQKL DAVVHPITQK LYSEGAGDAD  60
   61 EEDDDYFDDE ADEL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.0
Match:	1dkxA
Description:	DnaK
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: