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View Structure Prediction Details

Protein: esc1
Organism: Schizosaccharomyces pombe
Length: 413 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for esc1.

Description E-value Query
Range
Subject
Range
gi|73986628 - gi|73986628|ref|XP_867815.1| PREDICTED: similar to SWI/SNF-related matrix-associated actin-dependent...
124.0 [0..9] [411..43]
SMARCA2 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
119.0 [0..9] [411..44]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSYALPSMQ PTPTSSIPLR QMSQPTTSAP SNSASSTPYS PQQVPLTHNS YPLSTPSSFQ  60
   61 HGQTRLPPIN CLAEPFNRPQ PWHSNSAAPA SSSPTSATLS TAAHPVHTNA AQVAGSSSSY 120
  121 VYSVPPTNST TSQASAKHSA VPHRSSQFQS TTLTPSTTDS SSTDVSSSDS VSTSASSSNA 180
  181 SNTVSVTSPA 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [191-269]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSATPLPNQ PSQQQFLVSK NDAFTTFVHS VHNTPMQQSM YVPQQQTSHS SGASYQNESA  60
   61 NPPVQSPMQY SYSQGQPFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [270-413]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPQHKNQSFS ASPIDPSMSY VYRAPESFSS INANVPYGRN EYLRRVTSLV PNQPEYTGPY  60
   61 TRNPELRTSH KLAERKRRKE IKELFDDLKD ALPLDKSTKS SKWGLLTRAI QYIEQLKSEQ 120
  121 VALEAYVKSL EENMQSNKEV TKGT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.0
Match: 1nkpA
Description: Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.58879320178546 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.48787404513864 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
sterol response element binding 1.35908389783271 bayes_pls_golite062009
structure-specific DNA binding 1.05787100777909 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
promoter binding 0.94414084000081 bayes_pls_golite062009
double-stranded DNA binding 0.82134057325852 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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