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View Structure Prediction Details

Protein: esc1
Organism: Schizosaccharomyces pombe
Length: 413 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for esc1.

Description E-value Query
Range
Subject
Range
gi|73986628 - gi|73986628|ref|XP_867815.1| PREDICTED: similar to SWI/SNF-related matrix-associated actin-dependent...
124.0 [0..9] [411..43]
SMARCA2 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
119.0 [0..9] [411..44]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSYALPSMQ PTPTSSIPLR QMSQPTTSAP SNSASSTPYS PQQVPLTHNS YPLSTPSSFQ  60
   61 HGQTRLPPIN CLAEPFNRPQ PWHSNSAAPA SSSPTSATLS TAAHPVHTNA AQVAGSSSSY 120
  121 VYSVPPTNST TSQASAKHSA VPHRSSQFQS TTLTPSTTDS SSTDVSSSDS VSTSASSSNA 180
  181 SNTVSVTSPA 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [191-269]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSATPLPNQ PSQQQFLVSK NDAFTTFVHS VHNTPMQQSM YVPQQQTSHS SGASYQNESA  60
   61 NPPVQSPMQY SYSQGQPFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [270-413]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YPQHKNQSFS ASPIDPSMSY VYRAPESFSS INANVPYGRN EYLRRVTSLV PNQPEYTGPY  60
   61 TRNPELRTSH KLAERKRRKE IKELFDDLKD ALPLDKSTKS SKWGLLTRAI QYIEQLKSEQ 120
  121 VALEAYVKSL EENMQSNKEV TKGT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.0
Match: 1nkpA
Description: Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.58879320178546 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.48787404513864 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
sterol response element binding 1.35908389783271 bayes_pls_golite062009
structure-specific DNA binding 1.05787100777909 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
promoter binding 0.94414084000081 bayes_pls_golite062009
double-stranded DNA binding 0.82134057325852 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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