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View Structure Prediction Details

Protein: SPAC1F8.07c
Organism: Schizosaccharomyces pombe
Length: 594 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC1F8.07c.

Description E-value Query
Range
Subject
Range
gi|17232105, gi|... - gi|17232105|ref|NP_488653.1| acetolactate synthase 3 catalytic subunit [Nostoc sp. PCC 7120], gi|171...
gi|25291313 - pir||AE2382 acetohydroxy acid synthase [imported] - Nostoc sp. (strain PCC 7120)
527.0 [0..5] [569..29]
gi|75908969, gi|... - gi|75908969|ref|YP_323265.1| acetolactate synthase 3 catalytic subunit [Anabaena variabilis ATCC 294...
526.0 [0..5] [562..29]
gi|71671664, gi|... - gi|71674688|ref|ZP_00672434.1| Acetolactate synthase, large subunit, biosynthetic type [Trichodesmiu...
521.0 [0..10] [574..13]
gi|21226772, gi|... - gi|21226772|ref|NP_632694.1| acetolactate synthase 3 catalytic subunit [Methanosarcina mazei Go1], g...
518.0 [0..1] [565..1]
gi|77977565 - gi|77977565|ref|ZP_00833010.1| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...
517.0 [0..4] [560..9]
gi|77976113 - gi|77976113|ref|ZP_00831646.1| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...
515.0 [0..4] [560..24]
gi|22295020, gi|... - gi|22298839|ref|NP_682086.1| acetolactate synthase 3 catalytic subunit [Thermosynechococcus elongatu...
515.0 [0..7] [574..1]
gi|77962085 - gi|77962085|ref|ZP_00825910.1| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...
514.0 [0..4] [560..9]
gi|77958248 - gi|77958248|ref|ZP_00822285.1| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...
513.0 [0..4] [560..15]
gi|89048720, gi|... - gi|89075580|ref|ZP_01161985.1| acetolactate synthase III large subunit [Photobacterium sp. SKA34], g...
512.0 [0..6] [560..1]

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Predicted Domain #1
Region A:
Residues: [1-594]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKDAESTMT VGTYLAQRLV EIGIKNHFVV PGDYNLRLLD FLEYYPGLSE IGCCNELNCA  60
   61 FAAEGYARSN GIACAVVTYS VGALTAFDGI GGAYAENLPV ILVSGSPNTN DLSSGHLLHH 120
  121 TLGTHDFEYQ MEIAKKLTCA AVAIKRAEDA PVMIDHAIRQ AILQHKPVYI EIPTNMANQP 180
  181 CPVPGPISAV ISPEISDKES LEKATDIAAE LISKKEKPIL LAGPKLRAAG AESAFVKLAE 240
  241 ALNCAAFIMP AAKGFYSEEH KNYAGVYWGE VSSSETTKAV YESSDLVIGA GVLFNDYSTV 300
  301 GWRAAPNPNI LLNSDYTSVS IPGYVFSRVY MAEFLELLAK KVSKKPATLE AYNKARPQTV 360
  361 VPKAAEPKAA LNRVEVMRQI QGLVDSNTTL YAETGDSWFN GLQMKLPAGA KFEVEMQWGH 420
  421 IGWSVPSAMG YAVAAPERRT IVMVGDGSFQ LTGQEISQMI RHKLPVLIFL LNNRGYTIEI 480
  481 QIHDGPYNRI QNWDFAAFCE SLNGETGKAK GLHAKTGEEL TSAIKVALQN KEGPTLIECA 540
  541 IDTDDCTQEL VDWGKAVAPP TPVLLPLITR LKRTLFGKNM LHLDYKNYLD IRNT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 84.045757
Match: 1zpdA
Description: Pyruvate decarboxylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetolactate synthase activity 12.903449876837 bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups 12.3239025230705 bayes_pls_golite062009
pyruvate dehydrogenase activity 5.28857071459273 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 5.21233670052586 bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity 5.08663245333808 bayes_pls_golite062009
NAD or NADH binding 3.93430700665136 bayes_pls_golite062009
transcription regulator activity 2.9155913558118 bayes_pls_golite062009
DNA binding 2.43141001866996 bayes_pls_golite062009
nucleic acid binding 2.41433477472968 bayes_pls_golite062009
catalytic activity 2.25537597692103 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 2.15444163802756 bayes_pls_golite062009
transketolase activity 2.13705987575498 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 2.09493047697397 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 2.09493047697397 bayes_pls_golite062009
histone deacetylase activity 2.07818242335598 bayes_pls_golite062009
protein deacetylase activity 2.07076853700185 bayes_pls_golite062009
deoxyhypusine synthase activity 2.04735838056767 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 1.98546381612935 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.82969293063325 bayes_pls_golite062009
hydrolase activity 1.43067365161346 bayes_pls_golite062009
transcription factor activity 1.30143289828088 bayes_pls_golite062009
deacetylase activity 1.21596867135219 bayes_pls_golite062009
binding 1.17940168894417 bayes_pls_golite062009
transcription factor binding 1.14766678956419 bayes_pls_golite062009
phenylpyruvate decarboxylase activity 1.11553401986553 bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity 1.07090849835369 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 1.0611726850452 bayes_pls_golite062009
protein binding 0.992849906276347 bayes_pls_golite062009
cation transmembrane transporter activity 0.78591260444574 bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity 0.750929351082237 bayes_pls_golite062009
transcription repressor activity 0.614654207326026 bayes_pls_golite062009
transcription cofactor activity 0.54005617175343 bayes_pls_golite062009
ion transmembrane transporter activity 0.51426028502998 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.492590326775569 bayes_pls_golite062009
transferase activity 0.413024577830522 bayes_pls_golite062009
transcription corepressor activity 0.40721151987565 bayes_pls_golite062009
thiamin pyrophosphate binding 0.297191393111081 bayes_pls_golite062009
pyruvate decarboxylase activity 0.198062360371269 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.114062221123972 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle