YRC Public Data Repository - Protein Structure Prediction

Protein:	sec27
Organism:	Schizosaccharomyces pombe
Length:	796 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sec27.

Description	E-value	Query Range	Subject Range
gi\|148658115, gi... - gi\|148658115\|ref\|YP_001278320.1\| NB-ARC domain-containing protein [Roseiflexus sp. RS-1], gi\|1485702...	692.0	[0..5]	[745..770]
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=... gi\|25530855 - pir\|\|AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)	684.0	[0..15]	[633..865]
gi\|186464325, gi... - gi\|23128981\|ref\|ZP_00110817.1\| COG2319: FOG: WD40 repeat [Nostoc punctiforme PCC 73102], gi\|18668187...	670.0	[0..7]	[662..1165]
gi\|75701503, gi\|... - gi\|75907778\|ref\|YP_322074.1\| ribosome assembly protein 4 (RSA4) [Anabaena variabilis ATCC 29413], gi...	650.0	[0..7]	[579..1037]
COPB2_MOUSE - Coatomer subunit beta' OS=Mus musculus GN=Copb2 PE=1 SV=2	642.0	[0..3]	[792..4]
gi\|56789724 - gi\|56789724\|gb\|AAH88397.1\| Coatomer protein complex, subunit beta 2 (beta prime) [Rattus norvegicus]	642.0	[0..3]	[792..4]
gi\|115443476, gi... - gi\|115443476\|ref\|XP_001218545.1\| hypothetical protein ATEG_09923 [Aspergillus terreus NIH2624], gi\|1...	641.0	[0..2]	[612..637]
gi\|50752064 - gi\|50752064\|ref\|XP_422637.1\| PREDICTED: similar to beta prime cop [Gallus gallus]	641.0	[0..3]	[792..99]
gi\|55732092 - gi\|55732092\|emb\|CAH92752.1\| hypothetical protein [Pongo abelii] COPB2_PONAB - Coatomer subunit beta' OS=Pongo abelii GN=COPB2 PE=2 SV=1	641.0	[0..3]	[792..4]

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Predicted Domain #1

Region A:
Residues: [1-108]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMRLDFQRKL LSHTERVKAV DFHPTEPWVI ASHYNGQVGI WNYNTQTLVR SFDINDVPIR  60
   61 ACAFIARKNW FVCGSDDFQV RVYNYNTGEK VTQFEAHPDY IRALVVHP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.30103
Match:	2ovpB
Description:	No description for 2ovpB was found.

Predicted Domain #2

Region A:
Residues: [109-637]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQPFLLTSSD DMTIKCFNWD MSWKCVQTFE GHSRYVMSLA INPKDTNTFA SSCLDGTVKV  60
   61 WSFGSSVANF TLQAHDRGVN YVNYYPAGDK PYLITAGDDN LIKVWDYQTK ACVRILEGHT 120
  121 NNVSFAFFHS KFPIIISGSE DGTVKIWHTL SYSLIKSYNF SLDRAWCIAQ NKDNGLVTVG 180
  181 FDNGLITFSL GRDEPSVTMD SSGKVVWSNY NEVMSAMIRP AKEQSDLTDG SLISLSVKEL 240
  241 GTTELYPAVL KHSPNGRFVS VCGNGEYIVY TALAWRNKAY GKALDFAWSA DSNVYGSRTS 300
  301 DRSIVIHKNF KESNRLDLSY SCDKIFGGFL LGVVGSDFIC FYDWDTGILV RKIDVKPKGV 360
  361 YWNDDGRFVI LACDDDFYLL GFNAEMFYSA VESGTADEEE GVADSFEALA DVSESVVNGK 420
  421 WVAETFIYTT TAARLNYLIG DQTYKIANVE SSFYLLGYIP RDDRIYLTDR DMNVVSYSFN 480
  481 LAIIEYQSLV LKGDLEAAQG LLEQISETDR PRLSDFLSRL GYKEAALEL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.39794
Match:	1nr0A
Description:	Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histone methyltransferase activity (H3-K4 specific)	4.71992275913384	bayes_pls_golite062009
GTPase activity	4.02994814377904	bayes_pls_golite062009
actin binding	3.31804728298431	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.25521258308263	bayes_pls_golite062009
cytoskeletal protein binding	3.1056443224755	bayes_pls_golite062009
tubulin binding	2.76945430061825	bayes_pls_golite062009
microtubule binding	2.72684103222924	bayes_pls_golite062009
dynein binding	2.54821997913979	bayes_pls_golite062009
binding	2.42570478946173	bayes_pls_golite062009
transcription regulator activity	2.3610959773142	bayes_pls_golite062009
nucleic acid binding	2.30918780727915	bayes_pls_golite062009
transcription repressor activity	2.29049708962212	bayes_pls_golite062009
dynactin binding	2.07556426531897	bayes_pls_golite062009
histone methyltransferase activity	1.85632145559025	bayes_pls_golite062009
DNA binding	1.71685536470455	bayes_pls_golite062009
actin filament binding	1.5197243426595	bayes_pls_golite062009
structural molecule activity	1.47448876401574	bayes_pls_golite062009
transcription corepressor activity	1.41752877005447	bayes_pls_golite062009
protein methyltransferase activity	1.35170368882651	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.22384651674093	bayes_pls_golite062009
protein binding	1.21879977456466	bayes_pls_golite062009
transporter activity	1.21549336905926	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	1.15313682561559	bayes_pls_golite062009
lysine N-methyltransferase activity	1.15313682561559	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	1.15313682561559	bayes_pls_golite062009
receptor activity	1.12819778129653	bayes_pls_golite062009
G-protein-coupled receptor binding	1.11754260203517	bayes_pls_golite062009
transcription factor activity	1.08768505897883	bayes_pls_golite062009
microtubule plus-end binding	1.01166033978052	bayes_pls_golite062009
molecular transducer activity	0.974380908248463	bayes_pls_golite062009
signal transducer activity	0.974380908248463	bayes_pls_golite062009
protein transporter activity	0.964340340346761	bayes_pls_golite062009
type 1 angiotensin receptor binding	0.920323565472959	bayes_pls_golite062009
angiotensin receptor binding	0.920323565472959	bayes_pls_golite062009
	0.88172763425403	bayes_pls_golite062009
substrate-specific transporter activity	0.734793983890004	bayes_pls_golite062009
histone binding	0.685319917508843	bayes_pls_golite062009
transcription factor binding	0.489473003915035	bayes_pls_golite062009
dynein intermediate chain binding	0.443846546939402	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.426429095658617	bayes_pls_golite062009
kinase activity	0.387572734234845	bayes_pls_golite062009
snoRNA binding	0.347797037104681	bayes_pls_golite062009
receptor binding	0.316169754698691	bayes_pls_golite062009
transcription cofactor activity	0.30761651528651	bayes_pls_golite062009
protein kinase activity	0.229242350006544	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.226335610368636	bayes_pls_golite062009
enzyme regulator activity	0.161639372576406	bayes_pls_golite062009
structural constituent of cytoskeleton	0.118975415284669	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.00585398682921312	bayes_pls_golite062009
N-methyltransferase activity	0.00335766408304172	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [638-796]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGDSVQRFEL ALDAQRLDIA SQIAQELDDP LKWRSLGDAA LNAWDFVLAQ ECFEKGKDYG  60
   61 SLVLLYTATN NHEGLKELSQ LTKSTKINNT AFICSWLTNQ PAECVNILTS TQRYPEANLF 120
  121 AATYCPDEVK NVLPEWKVDL TKNQKERIAD SLGDLELKN

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.6
Match:	2ifuA
Description:	No description for 2ifuA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: