YRC Public Data Repository - Protein Structure Prediction

Protein:	cds1
Organism:	Schizosaccharomyces pombe
Length:	460 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cds1.

Description	E-value	Query Range	Subject Range
gi\|1096085, gi\|7... - gi\|794147\|emb\|CAA59410.1\| serine /threonine protein kinase [Schizosaccharomyces pombe], gi\|1096085\|p...	360.0	[0..1]	[460..1]
gi\|110761240 - gi\|110761240\|ref\|XP_396874.3\| PREDICTED: similar to Akt1 CG4006-PA, isoform A [Apis mellifera]	327.0	[0..110]	[458..118]
gi\|91080121 - gi\|91080121\|ref\|XP_967736.1\| PREDICTED: similar to CG4006-PA, isoform A [Tribolium castaneum]	324.0	[0..145]	[458..143]
gi\|122891117, gi... - gi\|37700244\|ref\|NP_937789.1\| AKT2 kinase [Danio rerio], gi\|182889760\|gb\|AAI65600.1\| Akt2 protein [Da...	323.0	[0..49]	[458..23]
gi\|114677297 - gi\|114677297\|ref\|XP_001142813.1\| PREDICTED: v-akt murine thymoma viral oncogene homolog 2 isoform 1 ...	322.0	[0..141]	[458..64]
gi\|115696683, gi... - gi\|115936246\|ref\|XP_001178541.1\| PREDICTED: similar to serine/threonine protein kinase [Strongylocen...	322.0	[0..107]	[458..97]
PK2_DICDI - Protein kinase 2 - Dictyostelium discoideum (Slime mold)	322.0	[0..63]	[459..49]
gi\|66804103, gi\|... - gi\|66804103\|ref\|XP_635853.1\| protein kinase 2 [Dictyostelium discoideum AX4], gi\|60464191\|gb\|EAL6235... PK2_DICDI - Protein kinase 2 OS=Dictyostelium discoideum GN=pkgB PE=1 SV=2	322.0	[0..63]	[459..49]
gi\|109124756 - gi\|109124756\|ref\|XP_001092909.1\| PREDICTED: v-akt murine thymoma viral oncogene homolog 2 isoform 1 ...	321.0	[0..141]	[458..126]
gi\|398924 - gi\|398924\|emb\|CAA81204.1\| Dakt1 serine-threonine protein kinase [Drosophila melanogaster]	321.0	[0..124]	[458..142]

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Predicted Domain #1

Region A:
Residues: [1-145]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEPEEATQA TQEAPLHVSQ NIAKQVVNNE NVFMKLVMTR MLDGKTEVIP LTTDVHNGFW  60
   61 RFGRHKSCEV VLNGPRVSNF HFEIYQGHRN DSDESENVVF LHDHSSNGTF LNFERLAKNS 120
  121 RTILSNGDEI RIGLGVPKDE ISFLC

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.97
Match:	1qu5A
Description:	Phosphotyrosine binding domain of Rad53
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	3.49130250684713	bayes_pls_golite062009
transcription regulator activity	3.13020166288045	bayes_pls_golite062009
DNA binding	2.99552004033076	bayes_pls_golite062009
nucleic acid binding	2.81220637832811	bayes_pls_golite062009
histone binding	2.49907512861453	bayes_pls_golite062009
protein binding	2.20369144716037	bayes_pls_golite062009
transforming growth factor beta receptor, cytoplasmic mediator activity	2.16945817502942	bayes_pls_golite062009
receptor signaling protein activity	1.86981735398675	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.86962688291741	bayes_pls_golite062009
kinase activity	1.81862841628054	bayes_pls_golite062009
transcription factor activity	1.81518687735417	bayes_pls_golite062009
structure-specific DNA binding	1.80379362156554	bayes_pls_golite062009
protein kinase activity	1.71310411241427	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.66136286081439	bayes_pls_golite062009
DNA replication origin binding	1.65275405413131	bayes_pls_golite062009
double-stranded DNA binding	1.64875926701369	bayes_pls_golite062009
sequence-specific DNA binding	1.58636372907213	bayes_pls_golite062009
transcription repressor activity	1.52097696229253	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase signaling protein activity	1.4597324111121	bayes_pls_golite062009
transcription activator activity	1.37559643803178	bayes_pls_golite062009
transferase activity	1.31313779244307	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.28748237525351	bayes_pls_golite062009
protein serine/threonine kinase activity	1.14082165984579	bayes_pls_golite062009
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	0.833789957086181	bayes_pls_golite062009
transcription factor binding	0.820790849849904	bayes_pls_golite062009
type I transforming growth factor beta receptor binding	0.804599000027271	bayes_pls_golite062009
promoter binding	0.752181947431975	bayes_pls_golite062009
signal transducer activity	0.597728117940736	bayes_pls_golite062009
molecular transducer activity	0.597728117940736	bayes_pls_golite062009
small conjugating protein ligase activity	0.449808058396269	bayes_pls_golite062009
SMAD binding	0.442971472842983	bayes_pls_golite062009
chromatin binding	0.434019593940368	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.354750697429	bayes_pls_golite062009
R-SMAD binding	0.18488905369604	bayes_pls_golite062009
damaged DNA binding	0.182219412947843	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [146-460]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QVPVKHSRDS QKNMIKSENS HYEIIRTLGS GTFAVVKLAV EVNSGKWYAI KIINKRKILL  60
   61 TSSEKRATEM FQREIDILKS LHHPGVVQCH EIFENDDELF IVMEYVEGGD LMDFLIANGS 120
  121 IDEQDCKPLL KQLLETLLHL HKQGVTHRDI KPENILITND FHLKISDFGL AKVIHGTGTF 180
  181 LETFCGTMGY LAPEVLKSKN VNLDGGYDDK VDIWSLGCVL YVMLTASIPF ASSSQAKCIE 240
  241 LISKGAYPIE PLLENEISEE GIDLINRMLE INPEKRISES EALQHPWFYT VSTHEHRTPP 300
  301 SSSEHEATEQ LNSSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	85.522879
Match:	2gnfA
Description:	No description for 2gnfA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: