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View Structure Prediction Details

Protein: Tango4-PA
Organism: Drosophila melanogaster
Length: 482 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Tango4-PA.

Description E-value Query
Range
Subject
Range
gi|186464325, gi... - gi|23128981|ref|ZP_00110817.1| COG2319: FOG: WD40 repeat [Nostoc punctiforme PCC 73102], gi|18668187...
560.0 [0..2] [482..1234]

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Predicted Domain #1
Region A:
Residues: [1-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMEDVQKHS VHTLIFRSLK RTHDLFVSNQ GNLPEIDERL EKLRRSIKAK DGYGLVLDKV  60
   61 AKIGEARKAS GAQTPGDKTL AITDGSATDA ASGAGSLVKY NAGARPAEKT APLVTGTHTS 120
  121 LVRASLANSN ADMSANGAIA SHLQLIPKKA PSIPKPKWHA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.221849
Match: 1k32A
Description: Tricorn protease; Tricorn protease N-terminal domain; Tricorn protease domain 2
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [161-482]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PWKLSRVISG HLGWVRCIAV EPGNEWFATG AGDRVIKIWD LASGKLKLSL TGHVSTVRGV  60
   61 AVSTKHPYLF SCGEDRQVKC WDLEYNKVIR HYHGHLSAVY SLALHPTIDV LATSGRDSTA 120
  121 RIWDMRTKAN VHTLTGHTNT VASVVAQATN PQIITGSHDS TVRLWDLAAG KSVCTLTNHK 180
  181 KSVRSIVLHP SLYMFASASP DNIKQWRCPE GKFVQNISGH TSIVNCMAAN SEGVLVSGGD 240
  241 NGTMFFWDWR TGYNFQRFQA PVQPGSMDSE AGIFAMCFDQ SGSRLITAEA DKTIKVYKED 300
  301 DEASEESHPI NWRPDLLKRR KF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.69897
Match: 1vyhC
Description: PAF-AH Holoenzyme: Lis1/Alfa2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
6.67009948605948 bayes_pls_golite062009
structural molecule activity 5.05435272846365 bayes_pls_golite062009
actin binding 3.86142918698875 bayes_pls_golite062009
acetyltransferase activity 3.85374902981345 bayes_pls_golite062009
RNA binding 3.77273677738815 bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific) 3.53507344623686 bayes_pls_golite062009
acyltransferase activity 3.35098520158193 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.31615347567536 bayes_pls_golite062009
GTPase activity 3.23750443966606 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.14917998298348 bayes_pls_golite062009
cytoskeletal protein binding 3.1056443224755 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.99343906593123 bayes_pls_golite062009
tubulin binding 2.76945430061825 bayes_pls_golite062009
microtubule binding 2.72684103222924 bayes_pls_golite062009
dynein binding 2.54821997913979 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
snoRNA binding 2.27164613239345 bayes_pls_golite062009
protein binding 2.26925404328312 bayes_pls_golite062009
actin filament binding 2.0735069176589 bayes_pls_golite062009
transcription repressor activity 2.03485691549401 bayes_pls_golite062009
dynactin binding 1.92897254169098 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
G-protein-coupled receptor binding 1.63631972867316 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 1.29381240188821 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
transcription corepressor activity 1.2107661925348 bayes_pls_golite062009
receptor activity 1.12819778129653 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
mRNA binding 1.05053985350578 bayes_pls_golite062009
microtubule plus-end binding 1.01166033978052 bayes_pls_golite062009
myosin binding 0.989691178611801 bayes_pls_golite062009
molecular transducer activity 0.974380908248463 bayes_pls_golite062009
signal transducer activity 0.974380908248463 bayes_pls_golite062009
type 1 angiotensin receptor binding 0.920323565472959 bayes_pls_golite062009
angiotensin receptor binding 0.920323565472959 bayes_pls_golite062009
kinase activity 0.807669232329985 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.805273887494167 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.634547834947756 bayes_pls_golite062009
DNA-dependent ATPase activity 0.625780732991652 bayes_pls_golite062009
protein kinase activity 0.544118712921054 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
dynein intermediate chain binding 0.443846546939402 bayes_pls_golite062009
transcription initiation factor activity 0.319410949467982 bayes_pls_golite062009
histone methyltransferase activity 0.311523647180993 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
nucleotidyltransferase activity 0.28606552120995 bayes_pls_golite062009
DNA helicase activity 0.220747580531792 bayes_pls_golite062009
hydrolase activity 0.181211933860468 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009
structural constituent of cytoskeleton 0.118975415284669 bayes_pls_golite062009
protein serine/threonine kinase activity 0.0803897416817422 bayes_pls_golite062009
receptor binding 0.0390635451962911 bayes_pls_golite062009
kinase binding 0.0366162235750993 bayes_pls_golite062009
myosin II binding 0.0145748031956598 bayes_pls_golite062009
protein kinase binding 0.00858004043229577 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle